PLoS ONE, 2013 BackgroundLigands of peroxisome-proliferator activated receptors (PPARs), such as non-esterified fatty acids (NEFAs), induce expression of angiopoietin-like protein 4 (ANGPTL4). Recently ANGPTL4 has been reported to be a mediator of intracellular adipose
Henar Ortega-Senovilla +5 more
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Angiopoietin-like protein 4 (ANGPTL4) is an inhibitor of endothelial lipase (EL) while the ANGPTL4/8 complex has reduced EL-inhibitory activity [PDF]
Heliyon, 2021 We previously demonstrated that angiopoietin-like protein 8 (ANGPTL8) forms ANGPTL3/8 and ANGPTL4/8 complexes that increase with feeding to direct fatty acids (FA) toward adipose tissue through differential modulation of lipoprotein lipase (LPL) activity.
Robert Siegel, Yan Q Chen
exaly +5 more sources
Mapping the sites of the lipoprotein lipase (LPL)–angiopoietin-like protein 4 (ANGPTL4) interaction provides mechanistic insight into LPL inhibition [PDF]
Journal of Biological Chemistry, 2019 Cardiovascular disease has been the leading cause of death throughout the world for nearly 2 decades. Hypertriglyceridemia affects more than one-third of the population in the United States and is an independent risk factor for cardiovascular disease.
Albert Bowers, Saskia Neher
exaly +5 more sources
A randomised, controlled, crossover study of the effect of diet on angiopoietin-like protein 4 (ANGPTL4) through modification of the gut microbiome [PDF]
Journal of Nutritional Science, 2016 Angiopoietin-like protein 4 (ANGPTL4) is a lipoprotein lipase inhibitor that is involved in lipid metabolism and angiogenesis. Animal studies have suggested that the ANGPTL4 protein is modulated by the gut microbiota, possibly through increased ...
Trine Blædel +9 more
doaj +7 more sources
Decreased Fat Storage by Lactobacillus Paracasei Is Associated with Increased Levels of Angiopoietin-Like 4 Protein (ANGPTL4) [PDF]
PLoS ONE, 2010 Intervention strategies for obesity are global issues that require immediate attention. One approach is to exploit the growing consensus that beneficial gut microbiota could be of use in intervention regimes. Our objective was to determine the mechanism by which the probiotic bacteria Lactobacillus paracasei ssp paracasei F19 (F19) could alter fat ...
Sven Pettersson +2 more
exaly +6 more sources
Role of Angiopoietin-like protein 4 (ANGPTL4) as a Predictive marker for Diabetic Nephropathy in type 2 Diabetes [PDF]
Al-Azhar International Medical Journal, 2022 Background: Angiopoietin-like protein 4 (ANGPTL4) is a glycoprotein that regulates LPL activity during fasting and thereby affects triglyceride metabolism.
Amr Rezk +3 more
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Pathophysiology, 2022 Biomarker identification is imperative for invasive breast carcinoma, which is more aggressive and associated with higher mortality and worse prognosis in younger patients (50 years).
Zaleha Kamaludin +4 more
doaj +2 more sources
Angiopoietin-like 4 (Angptl4) Protein Is a Physiological Mediator of Intracellular Lipolysis in Murine Adipocytes [PDF]
Journal of Biological Chemistry, 2012 Intracellular triacylglycerol (TG) hydrolysis and fatty acid release by the white adipose tissue (WAT) during a fast is stimulated by counter-regulatory factors acting in concert, although how adipocytes integrate these lipolytic inputs is unknown.
Jen-Chywan Wang, Suneil Koliwad
exaly +7 more sources
ANGPTL4 suppresses the profibrogenic functions of atrial fibroblasts induced by angiotensin II by up-regulating PPARγ [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): The present study’s objective was to investigate the association between angiopoietin-like 4 (ANGPTL4) levels and the prognosis of Atrial fibrillation (AF), the causative effect in angiotensin II- (Ang II) induced AF, and its underlying ...
Xi Zhu +5 more
doaj +1 more source
Advanced Science, 2023 Vesicle trafficking has emerged as an important process driving tumor progression through various mechanisms. Transforming growth factor beta (TGFβ)‐mediated secretion of Angiopoietin‐like 4 (ANGPTL4) is important for cancer development.
Dennis Frank +5 more
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