Results 21 to 30 of about 4,326 (177)

ANGPTL4 suppresses the profibrogenic functions of atrial fibroblasts induced by angiotensin II by up-regulating PPARγ [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): The present study’s objective was to investigate the association between angiopoietin-like 4 (ANGPTL4) levels and the prognosis of Atrial fibrillation (AF), the causative effect in angiotensin II- (Ang II) induced AF, and its underlying ...
Xi Zhu, Xiaogang Zhang, Wei Gu, Hanjun Zhao, Shuwen Hao, Zhongping Ning   +5 more
doaj   +1 more source

Synergistic inhibition of macular vascular permeability in diabetic edema: Ginsenoside Rg3 enhances ranibizumab efficacy by targeting angiopoietin-like protein 4 and vascular endothelial growth factor via neuropilin/RhoA signaling. [PDF]

J Diabetes Investig
Molecular mechanism of synergistic antagonism of ANGPTL4 and VEGF by ginsenoside Rg3 combined with ranibizumab, regulating the NRP/RhoA pathway to inhibit macular edema. ABSTRACT Aims This study investigated the molecular mechanisms by which ginsenoside Rg3 combined with ranibizumab alleviates diabetic macular edema (DME), focusing on antagonizing ...
Yu J, Li X, Liu Y.
europepmc   +2 more sources

Effect of empagliflozin on urinary albumin excretion and hypoxic biomarkers in early diabetic kidney disease: A randomised double-blind, placebo-controlled trial. [PDF]

Diabetes Obes Metab
Abstract Aims The precise mechanism of sodium glucose co‐transporter 2 (SGLT2) inhibitor on reno‐protective effect has been still unclear. In this study, we hypothesised that SGLT2 inhibitor prevents diabetic kidney disease via reduction of hypoxia‐induced factors.
Makino H, Kasahara M, Takashima R, Kasama S, Ozu N, Park H, Chen Q, Tsuruya K, Tochiya M, Omura-Ohata Y, Tamanaha T, Noguchi M, Aiba T, Yoshihara F, Hosoda K.   +14 more
europepmc   +2 more sources

Inhaled Angiopoietin-Like 4 Antisense Oligonucleotide Therapy for Lung Injury and Fibrosis. [PDF]

Adv Sci (Weinh)
Inhaled antisense oligonucleotides targeting ANGPTL4 attenuate inflammation, preserve barrier integrity, and reduce fibrosis in both infectious and sterile lung injury models. Integrated transcriptomic analysis reveals a conserved ANGPTL4‐regulated gene network coordinating hypoxic, inflammatory, apoptotic, and stress‐response pathways.
Fan H, Tan Y, Zhang J, Liu X, Qu J, Chua D, Cheng HS, Kim JHS, Liu YX, Qin C, Liu Y, Li D, Qiu J, Chi M, Bi M, Zhang Q, Li Y, Motamedi Joibari M, Nilsson SK, Tan NS, Fan Y, Li L.   +21 more
europepmc   +2 more sources

Single-cell transcriptomics reveals cellular heterogeneity and phenotypic transitions of smooth muscle cells in aortic dissection. [PDF]

Imeta
We utilized single‐cell RNA sequencing (scRNA‐seq) to investigate cellular heterogeneity and signaling networks in aortic dissection (AD) tissues compared to adjacent normal tissues. The analysis identified five smooth muscle cell (SMC) subtypes, with SMC2 linked to fibrosis and SMC3 associated with inflammation.
Shao L, Hu F, Zhao LN, Luo JP, Zou PT, Liu X, Zheng SY, Chen C, Ye LX, Zhou YX, Zhang J, Jin K, Zhang P.   +12 more
europepmc   +2 more sources

The PPARβ/Delta-Induced Mesenchymal Stromal Cell Secretome Has Cytoprotective Effects via ANGPTL4 in a Pre-Clinical Model of Acute Lung Inflammation. [PDF]

FASEB J
Activation of PPARβδ via chemical agonists or free fatty acids lead to the increased production of ANGPTL4 by human bone marrow (BM)‐MSCs. MSC‐conditioned medium (CM) derived ANGPTL4 promotes wound healing in lung epithelial cells in vitro, enhances endothelial barrier function in vivo and reduced pro‐inflammatory cytokine release in a pre‐clinical ...
Tunstead C, Dunlop M, Ryan S, Volkova E, Johnston E, Batah S, Dos Santos CC, McNicholas B, Masterson C, Laffey JG, English K.   +10 more
europepmc   +2 more sources

Vesicle‐Associated Actin Assembly by Formins Promotes TGFβ‐Induced ANGPTL4 Trafficking, Secretion and Cell Invasion

Advanced Science, 2023
Vesicle trafficking has emerged as an important process driving tumor progression through various mechanisms. Transforming growth factor beta (TGFβ)‐mediated secretion of Angiopoietin‐like 4 (ANGPTL4) is important for cancer development.
Dennis Frank, Christel Jessica Moussi, Svenja Ulferts, Lina Lorenzen, Carsten Schwan, Robert Grosse   +5 more
doaj   +1 more source

Lipopolysaccharide-induced podocyte injury is regulated by calcineurin/NFAT and TLR4/MyD88/NF-κB signaling pathways through angiopoietin-like protein 4

Genes and Diseases, 2022
Podocyte injury is an important cause of proteinuria. Angiopoietin-like protein 4 (Angptl4) is a secreted glycoprotein and has a role in proteinuria. However, the exact role of Angptl4 in podocyte injury and its upstream regulators has not been clarified.
Xiujin Shen, Chunhua Weng, Yucheng Wang, Cuili Wang, Shi Feng, Xiayu Li, Heng Li, Hong Jiang, Haibing Wang, Jianghua Chen   +9 more
doaj   +1 more source

Oligomerization state-dependent hyperlipidemic effect of angiopoietin-like protein 4

Journal of Lipid Research, 2004
Angiopoietin-like protein 4 (Angptl4) is the second member of the angiopoietin-like family of proteins previously shown to increase plasma triglyceride (TG) levels in vivo.
Hongfei Ge, Guoqing Yang, Xinxin Yu, Tiffany Pourbahrami, Cai Li   +4 more
doaj   +1 more source

Differential regulation and properties of angiopoietin-like proteins 3 and 4

Journal of Lipid Research, 2005
Angiopoietin-like protein 3 and 4 (Angptl3 and Angptl4) are two members of the angiopoietin-like family of proteins. These two closely related proteins have been reported to similarly affect lipid metabolism through their capacity to inhibit lipoprotein ...
Hongfei Ge, Ji-Young Cha, Harini Gopal, Christopher Harp, Xinxin Yu, Joyce J. Repa, Cai Li   +6 more
doaj   +1 more source