Results 21 to 30 of about 19,335,566 (141)

mRNA Expression of Ovine Angiopoietin-like Protein 4 Gene in Adipose Tissues [PDF]

Asian-Australasian Journal of Animal Sciences, 2016
Angiopoietin-like protein 4 (ANGPTL4) is involved in a variety of functions, including lipoprotein metabolism and angiogenesis. To reveal the role of ANGPTL4 in fat metabolism of sheep, ovine ANGPTL4 mRNA expression was analyzed in seven adipose tissues ...
Jing Zhang, Jiong-Jie Jing, Xia-Li Jia, Li-Ying Qiao, Jian-Hua Liu, Chen Liang, Wen-Zhong Liu   +6 more
doaj   +1 more source

Oligomerization state-dependent hyperlipidemic effect of angiopoietin-like protein 4

Journal of Lipid Research, 2004
Angiopoietin-like protein 4 (Angptl4) is the second member of the angiopoietin-like family of proteins previously shown to increase plasma triglyceride (TG) levels in vivo.
Hongfei Ge, Guoqing Yang, Xinxin Yu, Tiffany Pourbahrami, Cai Li   +4 more
doaj   +1 more source

Differential regulation and properties of angiopoietin-like proteins 3 and 4

Journal of Lipid Research, 2005
Angiopoietin-like protein 3 and 4 (Angptl3 and Angptl4) are two members of the angiopoietin-like family of proteins. These two closely related proteins have been reported to similarly affect lipid metabolism through their capacity to inhibit lipoprotein ...
Hongfei Ge, Ji-Young Cha, Harini Gopal, Christopher Harp, Xinxin Yu, Joyce J. Repa, Cai Li   +6 more
doaj   +1 more source

Angiopoietin-like 4 (Angptl4) [PDF]

, 2012
Angiopoietin-like 4 (Angptl4) is a secreted protein modulating triacylglycerol homeostasis. Its transcription is induced by glucocorticoids, which act to elevate circulating Angptl4 levels during fasting.
Koliwad, Suneil K, Wang, Jen-Chywan, Gray, Nora E   +2 more
core   +1 more source

Overexpression of Angiopoietin-Like Protein 4 Protects Against Atherosclerosis Development [PDF]

, 2013
Objective: Macrophage foam cells play a crucial role in several pathologies including multiple sclerosis, glomerulosclerosis, and atherosclerosis. Angiopoietin-like protein 4 (Angptl4) was previously shown to inhibit chyle-induced foam cell formation in ...
Tan, N.S., Vliet, J.A. van der, Janssen, A., Stienstra, R., Georgiadi, A., Smit, J.W., Rensen, P.C., Stalenhoef, A., Tjeerdema, N., Tamsma, J.T., Kersten, S., Müller, M., Wang, Y., Roos, A. de   +13 more
core   +2 more sources

ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression

Nature Communications, 2016
Angiopoietin-like 4 protein (ANGPTL4) is a regulator of lipoprotein metabolism whose role in atherosclerosis has been controversial. Here the authors show that ANGPTL4 deficiency in haematopoietic cells increases atherogenesis by promoting myeloid ...
Binod Aryal, Noemi Rotllan, Elisa Araldi, Cristina M. Ramírez, Shun He, Benjamin G. Chousterman, Ashley M. Fenn, Amarylis Wanschel, Julio Madrigal-Matute, Nikhil Warrier, Jose L. Martín-Ventura, Filip K. Swirski, Yajaira Suárez, Carlos Fernández-Hernando   +13 more
doaj   +1 more source

Peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) but not PPARalpha serves as a plasma free fatty acid sensor in liver [PDF]

, 2009
Peroxisome proliferator-activated receptor alpha (PPARalpha) is an important transcription factor in liver that can be activated physiologically by fasting or pharmacologically by using high-affinity synthetic agonists.
Degenhardt, Tatjana, Degerhardt, T., Kersten, A.H., Müller, Michael, Koppen, A., Sanderson, L., Kalkhoven, E., Müller, M.R., Koppen, Arjen, Sanderson, Linda M, Desvergne, Beatrice, Desvergne, B., Kalkhoven, Eric, Kersten, Sander, Sanderson, L.M., Degenhardt, T., Kersten, S., Müller, M.   +17 more
core   +1 more source

Characterization of ANGPTL4 function in macrophages and adipocytes using Angptl4-knockout and Angptl4-hypomorphic mice[S]

Journal of Lipid Research, 2019
Angiopoietin-like protein (ANGPTL)4 regulates plasma lipids, making it an attractive target for correcting dyslipidemia. However, ANGPTL4 inactivation in mice fed a high fat diet causes chylous ascites, an acute-phase response, and mesenteric ...
Antwi-Boasiako Oteng, PhilipM.M. Ruppert, Lily Boutens, Wieneke Dijk, XantheA.M.H. van Dierendonck, Gunilla Olivecrona, Rinke Stienstra, Sander Kersten   +7 more
doaj   +1 more source

Angiopoietin-like 4 mediates PPAR delta effect on lipoprotein lipase-dependent fatty acid uptake but not on beta-oxidation in myotubes. [PDF]

PLoS ONE, 2012
Peroxisome proliferator-activated receptor (PPAR) delta is an important regulator of fatty acid (FA) metabolism. Angiopoietin-like 4 (Angptl4), a multifunctional protein, is one of the major targets of PPAR delta in skeletal muscle cells.
Marius R Robciuc, Paulina Skrobuk, Andrey Anisimov, Vesa M Olkkonen, Kari Alitalo, Robert H Eckel, Heikki A Koistinen, Matti Jauhiainen, Christian Ehnholm   +8 more
doaj   +1 more source

Silencing of Angiopoietin‐Like Protein 4 (Angptl4) Decreases Inflammation, Extracellular Matrix Degradation, and Apoptosis in Osteoarthritis via the Sirtuin 1/NF‐κB Pathway

Oxidative Medicine and Cellular Longevity, 2022
Osteoarthritis (OA) is a frequently observed condition in aged people. OA cartilage is characterized by chondrocyte apoptosis, chondrocyte inflammation, and hyperactive catabolism of extracellular matrix. However, the specific molecular mechanisms remain unclear.
Chao Jia, Xiucui Li, Jun Pan, Haiwei Ma, Dengying Wu, Hongwei Lu, Wei Wang, Xutong Zhang, Xianhong Yi   +8 more
openaire   +2 more sources