Results 41 to 50 of about 4,326 (177)

Novel GPIHBP1-independent pathway for clearance of plasma TGs in Angptl4−/−Gpihbp1−/− mice

Journal of Lipid Research, 2018
Mice lacking glycosylphosphatidylinositol-anchored HDL-binding protein 1 (GPIHBP1) are unable to traffic LPL to the vascular lumen. Thus, triglyceride (TG) clearance is severely blunted, and mice are extremely hypertriglyceridemic.
Emily M. Cushing, Kelli L. Sylvers, Xun Chi, Shwetha K. Shetty, BrandonS.J. Davies   +4 more
doaj   +1 more source

Angiopoietin-like 4 promotes intracellular degradation of lipoprotein lipase in adipocytes

Journal of Lipid Research, 2016
LPL hydrolyzes triglycerides in triglyceride-rich lipoproteins along the capillaries of heart, skeletal muscle, and adipose tissue. The activity of LPL is repressed by angiopoietin-like 4 (ANGPTL4) but the underlying mechanisms have not been fully ...
Wieneke Dijk, Anne P. Beigneux, Mikael Larsson, André Bensadoun, Stephen G. Young, Sander Kersten   +5 more
doaj   +1 more source

ANGPTL4 functions as an oncogene through regulation of the ETV5/CDH5/AKT/MMP9 axis to promote angiogenesis in ovarian cancer

Journal of Ovarian Research, 2022
Background Angiopoietin-like 4 (ANGPTL4) is highly expressed in a variety of neoplasms and promotes cancer progression. Nevertheless, the mechanism of ANGPTL4 in ovarian cancer (OC) metastasis remains unclear. This study aimeds to explore whether ANGPTL4
Yinping Liu, Rui Yang, Yan Zhang, Yaping Zhu, Wei Bao   +4 more
doaj   +1 more source

CGRP Enhances the Regeneration of Bone Defects by Regulating Bone Marrow Mesenchymal Stem Cells Through Promoting ANGPTL4 Secretion by Bone Blood Vessels. [PDF]

Adv Sci (Weinh)
CGRP interacts with HMEC‐1 by binding to surface receptors, influencing the downstream FAK/AKT/VEGF signaling pathway, and promoting the secretion of ANGPTL4 from vascular endothelial cells into the bone microenvironment. This, in turn, regulates the differentiation of BMSCs into osteoblasts, thus promoting bone formation. ABSTRACT Bone angiogenesis is
Lu Q, Zheng Q, Zhou Z, Chen Y, Chen Y, Chen W, Wang J, Guo R, Wu R, Chen L.   +9 more
europepmc   +2 more sources

The role of Angiopoietin-like protein 4 in macrophage activation

, 2020
Angiopoietin-like protein 4 (Angptl4) is a matricellular protein that associates with extracellular matrix proteins, mediating complex cell-cell, and cell-matrix interactions.
Wee, Jonathan Wei Kiat
core   +1 more source

Repression of glucocorticoid-stimulated angiopoietin-like 4 gene transcription by insulin

Journal of Lipid Research, 2014
Angiopoietin-like 4 (Angptl4) is a glucocorticoid receptor (GR) primary target gene in hepatocytes and adipocytes. It encodes a secreted protein that inhibits extracellular LPL and promotes adipocyte lipolysis.
Taiyi Kuo, Tzu-Chieh Chen, Stephanie Yan, Fritz Foo, Cecilia Ching, Allison McQueen, Jen-Chywan Wang   +6 more
doaj   +1 more source

Relationship between serum angiopoietin-like 4 levels and recurrence of atrial fibrillation

Journal of International Medical Research, 2021
Objective To investigate the association between serum angiopoietin-like 4 (ANGPTL4) levels and recurrence of atrial fibrillation (AF) after catheter ablation.
Zhongping Ning, Xinming Li, Xi Zhu, Jun Luo, Yingbiao Wu   +4 more
doaj   +1 more source

Advances in Gastric Cancer Research: Insights Into Carcinogenesis, the Tumor Microenvironment, Metastasis, and Factors Influencing Prognosis

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background The Department of Gastroenterological Surgery at Kumamoto University has maintained a commitment to integrating cutting‐edge clinical practice with fundamental research, particularly concerning malignant diseases of the digestive tract.
Hideo Baba, Takatsugu Ishimoto, Yoshifumi Baba, Hiromitsu Hayashi, Masaaki Iwatsuki   +4 more
wiley   +1 more source

Peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) but not PPARalpha serves as a plasma free fatty acid sensor in liver

, 2009
Peroxisome proliferator-activated receptor alpha (PPARalpha) is an important transcription factor in liver that can be activated physiologically by fasting or pharmacologically by using high-affinity synthetic agonists.
Degenhardt, Tatjana, Degerhardt, T., Kersten, A.H., Müller, Michael, Koppen, A., Sanderson, L., Kalkhoven, E., Müller, M.R., Koppen, Arjen, Sanderson, Linda M, Desvergne, Beatrice, Desvergne, B., Kalkhoven, Eric, Kersten, Sander   +13 more
core   +1 more source

Excipient of paclitaxel induces metabolic dysregulation and unfolded protein response

iScience, 2021
Summary: Taxane-based reagents, such as Taxol, Taxotere, and Abraxane, are popular anti-cancer drugs that can differ in their clinical efficacy. This difference is generally attributed to their active pharmaceutical ingredients.
Qian Dai, Xiaolin Liu, Tao He, Chao Yang, Jinfeng Jiang, Yin Fang, Zhoukai Fu, Yuan Yuan, Shujun Bai, Tong Qiu, Rutie Yin, Ping Ding, Jie Chen, Qintong Li   +13 more
doaj   +1 more source