Results 31 to 40 of about 19,335,566 (141)

ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure

eLife, 2015
Brown adipose tissue (BAT) activation via cold exposure is increasingly scrutinized as a potential approach to ameliorate cardio-metabolic risk. Transition to cold temperatures requires changes in the partitioning of energy substrates, re-routing fatty ...
Wieneke Dijk, Markus Heine, Laurent Vergnes, Mariëtte R Boon, Gert Schaart, Matthijs KC Hesselink, Karen Reue, Wouter D van Marken Lichtenbelt, Gunilla Olivecrona, Patrick CN Rensen, Joerg Heeren, Sander Kersten   +11 more
doaj   +1 more source

Expression of angiopoietin-like 4 in human gastric cancer: ANGPTL4 promotes venous invasion [PDF]

, 2010
There is strong evidence that the angiopoietin family is involved in the regulation of tumour progression, cellular growth and differentiation. Recently, it has been reported that angiopoietin-like 4 (ANGPTL4) in cancer cell promotes the metastatic ...
Taguchi, Takashi, Hirakawa, Hiroshi, Nagayasu, Takeshi, Abe, Kuniko, Nakayama, Toshiyuki, Shibata, Kenichiro   +5 more
core   +2 more sources

ANGPTL4 Attenuates Ang II-Induced Atrial Fibrillation and Fibrosis in Mice via PPAR Pathway

Cardiology Research and Practice, 2021
Atrial fibrillation (AF) is the more significant portion of arrhythmia in clinical practice, with inflammation and fibrosis as its central pathological mechanisms.
Xi Zhu, Xiaogang Zhang, Xinpeng Cong, Luoning Zhu, Zhongping Ning   +4 more
doaj   +1 more source

Regulation of angiopoietin-like protein 4/fasting-induced adipose factor (Angptl4/FIAF) expression in mouse white adipose tissue and 3T3-L1 adipocytes [PDF]

British Journal of Nutrition, 2008
Angiopoietin-like protein 4 (Angptl4)/FIAF (fasting-induced adipose factor) was first identified as a target for PPAR and to be strongly induced in white adipose tissue (WAT) by fasting. Here we have examined the regulation of the expression and release of this adipokine in mouse WAT and in 3T3-L1 adipocytes.
Sarah, Dutton, Paul, Trayhurn
openaire   +2 more sources

Brown adipose tissue derived ANGPTL4 controls glucose and lipid metabolism and regulates thermogenesis

Molecular Metabolism, 2018
Objectives: Brown adipose tissue (BAT) controls triglyceride-rich lipoprotein (TRL) catabolism. This process is mediated by the lipoprotein lipase (LPL), an enzyme that catalyzed the hydrolysis of triglyceride (TAG) in glycerol and fatty acids (FA ...
Abhishek K. Singh, Binod Aryal, Balkrishna Chaube, Noemi Rotllan, Luis Varela, Tamas L. Horvath, Yajaira Suárez, Carlos Fernández-Hernando   +7 more
doaj   +1 more source

Single-cell analysis of skin immune cells reveals an Angptl4-ifi20b axis that regulates monocyte differentiation during wound healing

Cell Death and Disease, 2022
The persistent inflammatory response at the wound site is a cardinal feature of nonhealing wounds. Prolonged neutrophil presence in the wound site due to failed clearance by reduced monocyte-derived macrophages delays the transition from the inflammatory
Wei Kiat Jonathan Wee, Zun Siong Low, Chin Kiat Ooi, Benjamin Patrana Henategala, Zhi Guang Ridley Lim, Yun Sheng Yip, Marcus Ivan Gerard Vos, William Wei Ren Tan, Hong Sheng Cheng, Nguan Soon Tan   +9 more
doaj   +1 more source

Angiopoietin-Like Protein 4 (ANGPTL4) Induces Retinal Pigment Epithelial Barrier Breakdown by Activating Signal Transducer and Activator of Transcription 3 (STAT3): Evidence from ARPE-19 Cells Under Hypoxic Condition and Diabetic Rats [PDF]

Medical Science Monitor, 2019
BACKGROUND Diabetic retinopathy is a primary contributor of visual impairment in adult diabetes mellitus patients. Diabetic retinopathy causes breakdown of blood retinal barrier (BRB), and leads to diabetic macular edema. Previous studies have demonstrated angiopoietin-like protein 4 (ANGPTL4) as an effective diabetic retinopathy therapeutic target ...
Yang, Xinyue, Cao, Jinfeng, Du, Yang, Gong, Qiaoyun, Cheng, Yan, Su, Guanfang   +5 more
openaire   +2 more sources

Novel GPIHBP1-independent pathway for clearance of plasma TGs in Angptl4−/−Gpihbp1−/− mice

Journal of Lipid Research, 2018
Mice lacking glycosylphosphatidylinositol-anchored HDL-binding protein 1 (GPIHBP1) are unable to traffic LPL to the vascular lumen. Thus, triglyceride (TG) clearance is severely blunted, and mice are extremely hypertriglyceridemic.
Emily M. Cushing, Kelli L. Sylvers, Xun Chi, Shwetha K. Shetty, BrandonS.J. Davies   +4 more
doaj   +1 more source

Angiopoietin-like 4 promotes intracellular degradation of lipoprotein lipase in adipocytes

Journal of Lipid Research, 2016
LPL hydrolyzes triglycerides in triglyceride-rich lipoproteins along the capillaries of heart, skeletal muscle, and adipose tissue. The activity of LPL is repressed by angiopoietin-like 4 (ANGPTL4) but the underlying mechanisms have not been fully ...
Wieneke Dijk, Anne P. Beigneux, Mikael Larsson, André Bensadoun, Stephen G. Young, Sander Kersten   +5 more
doaj   +1 more source

Angiopoietin-like 4 : a decade of research [PDF]

, 2012
The past decade has seen a rapid development and increasing recognition of ANGPTL4 (angiopoietin-like 4) as a remarkably multifaceted protein that is involved in many metabolic and non-metabolic conditions. ANGPTL4 has been recognised as a central player
Goh, Yan Yih, Tan, Nguan Soon, Chin, Alison Hwee Fang, Zhu, Pengcheng, Kersten, Sander   +4 more
core   +2 more sources