Results 11 to 20 of about 19,335,566 (141)

Angiopoietin-like protein 4 (ANGPTL4) is related to gestational weight gain in pregnant women with obesity [PDF]

Scientific Reports, 2018
AbstractAngiopoietin-like protein 4 (ANGPTL4) is a circulating protein involved in the regulation of adipose tissue metabolism. However, its role in obesity and pregnancy is unknown. To evaluate the relationship between gestational weight gain (GWG) and circulating concentrations of ANGPTL4 in pregnant women with overweight and obesity, weight gain and
Henar Ortega-Senovilla, Mireille N. M. van Poppel, Gernot Desoye, Emilio Herrera   +3 more
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Identification and characterization of angiopoietin-like 4 (ANGPTL4) interacting proteins in wound repair [PDF]

, 2019
Cutaneous wound healing is a complex and highly coordinated process of proliferation and migration of keratinocytes at the wound edge through interactions of different signaling molecules. Growth factors, transmembrane protein integrins and extracellular matrix play an important role in epidermal wound healing process, although the interplay among ...
Mintu Pal
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Angiopoietin-like 4 (ANGPTL4) Suppression Ameliorates Lupus Nephritis in MRL/lpr Mice by Inactivating NLRP3 Inflammasome and Inhibiting Inflammatory Response [PDF]

Iranian Journal of Immunology, 2023
Background: Lupus nephritis (LN) refers to the injury caused by systemic lupus erythematosus (SLE) involving the kidneys. A previous study identified angiopoietin-like protein 4 (ANGPTL4) as a novel urinary biomarker for tracking disease activity in LN ...
Dan Luo, Jun Li, Manli Hu, You Wang, Pei Pi, Min Ning, Jun Wu   +6 more
doaj   +3 more sources

Angiopoietin-like 4 regulates epidermal differentiation.

PLoS ONE, 2011
The nuclear hormone receptor PPARβ/δ is integral to efficient wound re-epithelialization and implicated in epidermal maturation. However, the mechanism underlying the latter process of epidermal differentiation remains unclear.
Mintu Pal, Ming Jie Tan, Royston-Luke Huang, Yan Yih Goh, Xiao Ling Wang, Mark Boon Yang Tang, Nguan Soon Tan   +6 more
doaj   +2 more sources

Decoding the role of angiopoietin-like protein 4/8 complex–mediated plasmin generation in the regulation of LPL activity

Journal of Lipid Research, 2023
After feeding, adipose tissue lipoprotein lipase (LPL) activity should be maximized, therefore the potent LPL-inhibitory activity of angiopoietin-like protein 4 (ANGPTL4) must be blocked by ANGPTL8 through formation of ANGPTL4/8 complexes.
Yan Q. Chen, Eugene Y. Zhen, Anna M. Russell, Mariam Ehsani, Robert W. Siegel, Yuewei Qian, Robert J. Konrad   +6 more
doaj   +2 more sources

Angiopoietin-like protein 4 is an exercise-induced hepatokine in humans, regulated by glucagon and cAMP [PDF]

Molecular Metabolism, 2017
Objective: Angiopoietin-like protein-4 (ANGPTL4) is a circulating protein that is highly expressed in liver and implicated in regulation of plasma triglyceride levels.
Bodil Ingerslev, Jakob S. Hansen, Christoph Hoffmann, Jens O. Clemmesen, Niels H. Secher, Mika Scheler, Martin Hrabĕ de Angelis, Hans U. Häring, Bente K. Pedersen, Cora Weigert, Peter Plomgaard   +10 more
doaj   +3 more sources

Fatty Acids and Hypoxia Stimulate the Expression and Secretion of the Adipokine ANGPTL4 (Angiopoietin-Like Protein 4/ Fasting-Induced Adipose Factor) by Human Adipocytes

Lifestyle Genomics, 2011
<i>Background/Aims:</i> Hypoxia occurs in white adipose tissue in obesity, modulating the expression and release of specific inflammation-related adipokines. ANGPTL4 (angiopoietin-like protein 4/fasting-induced adipose factor), which is implicated in angiogenesis, lipid metabolism and glucose homeostasis, is a major hypoxia-sensitive gene ...
Pedro, González-Muniesa, Cristiane, de Oliveira, Fátima, Pérez de Heredia, Mary P, Thompson, Paul, Trayhurn   +4 more
openaire   +3 more sources

Angiopoietin-like protein 4 dysregulation in kidney diseases: a promising biomarker and therapeutic target [PDF]

Frontiers in Pharmacology
The global burden of renal diseases is increasingly severe, underscoring the need for in-depth exploration of the molecular mechanisms underlying renal disease progression and the development of potential novel biomarkers or therapeutic targets ...
Yan Li, Yan Li, Yan Li, Yuxin Zhang, Yuxin Zhang, Yuxin Zhang, Mengxia Cao, Mengxia Cao, Mengxia Cao, Tingting Yuan, Tingting Yuan, Tingting Yuan, Santao Ou, Santao Ou, Santao Ou   +14 more
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Angiopoietin like protein 4 (ANGPTL4): a marker of alteration in lipid metabolism, insulin resistance and ectopic fat accumulation

, 2016
Alteration in lipid metabolism is a benchmark in the development of insulin resistance, type 2 diabetes and related cardiometabolic diseases. Angiopoietin like proteins (ANGPTL) are a family of secreted glycoproteins present in tissues (liver, heart, muscle, adipose tissue), macrophages and blood with pleiotropic effects on vascular cells, stem cell ...
Gastaldelli, A., Gaggini, M., ROSSO, CHIARA, Della Latta, V., MARIETTI, Milena, CAVIGLIA, GIAN PAOLO, Carli, F., Buzzigoli, E., Ciociaro, D., ABATE, Maria Lorena, SMEDILE, Antonina, SARACCO, Giorgio Maria, BUGIANESI, Elisabetta   +12 more
openaire   +3 more sources

Lipopolysaccharide-induced podocyte injury is regulated by calcineurin/NFAT and TLR4/MyD88/NF-κB signaling pathways through angiopoietin-like protein 4

Genes and Diseases, 2022
Podocyte injury is an important cause of proteinuria. Angiopoietin-like protein 4 (Angptl4) is a secreted glycoprotein and has a role in proteinuria. However, the exact role of Angptl4 in podocyte injury and its upstream regulators has not been clarified.
Xiujin Shen, Chunhua Weng, Yucheng Wang, Cuili Wang, Shi Feng, Xiayu Li, Heng Li, Hong Jiang, Haibing Wang, Jianghua Chen   +9 more
doaj   +1 more source