Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration
Advanced Healthcare Materials, Volume 15, Issue 23, 19 June 2026.Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu +4 more
wiley +1 more source
Electrical Stimulation Directs Formation of Perfused Vasculature in Engineered Tissues
Advanced Science, Volume 13, Issue 33, 15 June 2026.Electrical stimulation (ESTIM) enhances vasculature formation in engineered human tissues. In 3D endothelial‐fibroblast constructs, conditioning with ESTIM promotes the formation of dense and highly branched networks that rapidly anastomose with mouse vasculature when implanted in vivo. Vessels formed under ESTIM are importantly functionally perfusable.
Katarzyna A. Grzelak +6 more
wiley +1 more source
Serum Angiopoietin-Like Protein 4: A Potential Prognostic Biomarker for Prediction of Vascular Invasion and Lymph Node Metastasis in Cholangiocarcinoma Patients. [PDF]
Front Public Health, 2022 Aung TM +7 more
europepmc +1 more source
Mechanisms of Pericyte‐Mediated Cancer Metastasis
Advanced Science, Volume 13, Issue 33, 15 June 2026.Pericytes play multifarious roles in promoting cancer metastasis by facilitating metastatic cancer cell dissemination, circulating tumor cell survival, tissue extravasation, premetastatic niche formation, and metastatic tumor growth. These cells have intertwined interactions with vascular endothelial cells to modulate cancer cell behavior and ...
Ziheng Guo, Yihai Cao
wiley +1 more source
The Angiopoietin-like protein 4: a promising biomarker to distinguish brucella spondylitis from tuberculous spondylitis. [PDF]
Clin Rheumatol, 2021 Lan S, He Y, Tiheiran M, Liu W, Guo H.
europepmc +1 more source
Angiopoietin-like protein 8(ANGPTL8) secreted by liver and adipose tissue, is a glycoprotein exerting paramount effects on facilitation of vascular remodeling and regulation of inflammatory response; ANGPTL8 is involved in the initiation and progression ...
HAN Lijie, HU Chaowei, YU Huahui, QIN Yanwen
core +1 more source
Decoding Undesirable Inflammatory Responses of Nucleic Acid‐Delivering Lipid Nanoparticles
Advanced Science, Volume 13, Issue 33, 15 June 2026.Lipid nanoparticles (LNPs) enable efficient nucleic acid delivery, but their immunogenicity is a double‐edged sword. This review explores LNP‐driven innate and adaptive immunity, covering lipid components, endosomal escape, and nucleic acid sensing.
Ruimin Hu +6 more
wiley +1 more source
Recombinant angiopoietin-like protein 4 attenuates intestinal barrier structure and function injury after ischemia/reperfusion. [PDF]
World J Gastroenterol, 2021 Wang ZY +10 more
europepmc +1 more source
, 2009 熊本大学博士（医学）In 2000，several groups repoted Angiopoetin like protein family 4 (Angptl 4) as one of "angiopoietin-like proteins" (Angptls). Angptls possess an N-terminal coiled-coil domain and a C-terminal, both characteristic of angiopoietins.
足立, 博紀 +2 more
core
Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.Abstract The majority of breast cancer‐related deaths result from metastatic progression, especially brain metastasis, associated with the poorest prognosis. Patients with triple‐negative breast cancer (TNBC) are particularly prone to developing brain metastases.
Eloise Happernegg +11 more
wiley +1 more source