Results 121 to 130 of about 20,336,744 (217)

Angiopoietin-like Protein 4 Inhibition of Lipoprotein Lipase: EVIDENCE FOR REVERSIBLE COMPLEX FORMATION [PDF]

, 2013
Elevated triglycerides are associated with an increased risk of cardiovascular disease, and lipoprotein lipase (LPL) is the rate-limiting enzyme for the hydrolysis of triglycerides from circulating lipoproteins. The N-terminal domain of angiopoietin-like
Neher, Saskia B., Erie, Dorothy A., Bradford, Kira C., Lafferty, Michael J.   +3 more
core   +1 more source

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

British Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher, Mérone Da Costa Oliveira, Adrien Levesque, Alexandre Rutault, Patrick Savoyaud, Nicolas Bréchot, Stéphane Germain   +6 more
wiley   +1 more source

Der Effekt von Entzündungsmediatoren auf die Produktion von Angiopoietin-like 4 in parodontalen Fibroblasten unter hypoxischen Bedingungen.

, 2019
Einleitung: Parodontale Erkrankungen stellen in der Zahnheilkunde ein für Zahnverlust verantwortliches Problem dar. Es ist bekannt, dass das Zusammenspiel vieler Faktoren für die Entstehung dieser oft schwer therapierbaren Krankheit die Schuld trägt.
Kernstock, Kurt
core  

Gut microbiota as a novel therapeutic target for eating disorders and obesity

British Journal of Pharmacology, EarlyView.
The graphical abstract highlights the bidirectional interaction between the gut microbiota and central homeostatic and hedonic mechanisms regulating food intake, which contributes to overweight and obesity. It also illustrates emerging microbiota‐based biomarkers and therapeutic strategies (including prebiotics, probiotics, postbiotics, synbiotics and ...
Solveiga Samulėnaitė, Victor Mathis, Emmanuel Darcq, Aurelijus Burokas, Elena Martín‐García, Rafael Maldonado   +5 more
wiley   +1 more source

Long non‐coding RNAs at the crossroads of inflammation, cancer and angiogenesis: Molecular mechanisms and their potential as therapeutic targets

British Journal of Pharmacology, EarlyView.
Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff, Pamela Calle‐Mendoza, Maria Hatziapostolou, Christos Polytarchou   +3 more
wiley   +1 more source

Positive correlation of the serum angiopoietin-like protein 3 levels with the aortic augmentation index in patients with coronary artery disease

, 2018
Yu-Shan Fu,1,* Ji-Hung Wang,1,2,* Chung-Jen Lee,3 Bang-Gee Hsu1,4 1School of Medicine, Tzu Chi University, Hualien, 2Division of Cardiology, Buddhist Tzu Chi General Hospital, Hualien, 3Department of Nursing, Tzu Chi University of Science and Technology,
Lee CJ, Wang JH, Fu YS, Hsu BG
core  

The impacts of Angiopoetin like protein family 4 on dyslipidemia, atherosclerosis and macrophage foam cell formation [PDF]

, 2009
熊本大学博士（医学）In 2000，several groups repoted Angiopoetin like protein family 4 (Angptl 4) as one of "angiopoietin-like proteins" (Angptls). Angptls possess an N-terminal coiled-coil domain and a C-terminal, both characteristic of angiopoietins.
足立, 博紀, アダチ, ヒロノリ, Adachi, Hironori   +2 more
core   +1 more source

Zeb2 Controls Retinal Physiological and Pathological Angiogenesis by Regulating Astrocyte Proliferation and Differentiation

Cell Proliferation, EarlyView.
During development, the oxygen‐sensitive transcription factor Zeb2 restrains astrocyte proliferation and maturation to ensure balanced retinal angiogenesis. In disease, it promotes the neurotoxic A1 astrocyte phenotype and inflammation, thereby promoting reparative revascularization over pathological neovascularization.
Jing Liu, Yanan Guo, Kangjian Xiang, Shuyi Wang, Dongchang Xiao, Mengqing Xiang   +5 more
wiley   +1 more source

Rethinking diabetic retinopathy: Homeostatic mechanisms for retinal clearance

Diabetic Medicine, EarlyView.
In the healthy retina, balanced production and clearance of metabolic waste and fluid maintain retinal homeostasis and normal visual function. Diabetes disrupts this balance, increasing the accumulation of metabolic waste products, including advanced glycation end products (AGEs) and advanced lipoxidation end products (ALEs), while impairing waste and ...
Karis Little, Judith Lechner, Giulia De Rossi, Tara Cullen, Jennifer Perais, Eleni Beli, Noemi Lois, Alan W. Stitt   +7 more
wiley   +1 more source

Angiopoietin-like 4 regulates epidermal differentiation.

, 2011
The nuclear hormone receptor PPARβ/δ is integral to efficient wound re-epithelialization and implicated in epidermal maturation. However, the mechanism underlying the latter process of epidermal differentiation remains unclear.
Tan, Nguan Soon, Xiao Ling Wang, Tan, Ming Jie, Huang, Royston-Luke, Royston-Luke Huang, Wang, Xiao Ling, Ming Jie Tan, Nguan Soon Tan, Goh, Yan Yih, Tang, Mark Boon Yang, Mark Boon Yang Tang, Yan Yih Goh, Mintu Pal   +12 more
core   +1 more source