Results 51 to 60 of about 94,755 (223)

Triglyceride-Rich Lipoproteins: Their Role in Atherosclerosis

Revista de Investigación Clínica, 2022
The term “triglyceride-rich lipoproteins” (TRLs) includes chylomicrons and their remnants, very low-density lipoproteins (VLDL), and intermediate-density lipoproteins (IDL).
Yulino Castillo-Núñez, Enrique Morales-Villegas, Carlos A. Aguilar-Salinas   +2 more
doaj   +1 more source

Angiopoietin-like protein 8 differentially regulates ANGPTL3 and ANGPTL4 during postprandial partitioning of fatty acids[S]

Journal of Lipid Research, 2020
Angiopoietin-like protein (ANGPTL)8 has been implicated in metabolic syndrome and reported to regulate adipose FA uptake through unknown mechanisms. Here, we studied how complex formation of ANGPTL8 with ANGPTL3 or ANGPTL4 varies with feeding to regulate
Yan Q. Chen, Thomas G. Pottanat, Robert W. Siegel, Mariam Ehsani, Yue-Wei Qian, Eugene Y. Zhen, Ajit Regmi, William C. Roell, Haihong Guo, M. Jane Luo, Ruth E. Gimeno, Ferdinand van't Hooft, Robert J. Konrad   +12 more
doaj   +1 more source

Targeting ANGPTL3 by GalNAc-conjugated siRNA ANGsiR10 lowers blood lipids with long-lasting and potent efficacy in mice and monkeys

Molecular Therapy: Nucleic Acids, 2023
Angiopoietin-like protein 3 (ANGPTL3) is an important regulator of lipoproteins by inhibiting both lipoprotein and endothelial lipases. It has been intensively investigated as a drug target for the treatment of dyslipidemia.
Jue Wang, Wen Zheng, Shuquan Zheng, Ye Yuan, Wei Wen, Weiyi Cui, Lifang Xue, Xueting Sun, Haibao Shang, Hongyan Zhang, Rui-Ping Xiao, Shan Gao, Xiuqin Zhang   +12 more
doaj   +1 more source

Quantitation of serum angiopoietin-like proteins 3 and 4 in a Finnish population sample [PDF]

Journal of Lipid Research, 2010
We have developed and validated quantitative ELISAs for human angiopoietin-like (ANGPTL)3 and 4 and correlated their serum levels with parameters of lipid and carbohydrate metabolism. For this study, we used a random subsample of the Health 2000 Health Examination Survey consisting of 125 men and 125 women, aged 30-94 years.
Robciuc, Marius R., Tahvanainen, Esa, Jauhiainen, Matti, Ehnholm, Christian   +3 more
openaire   +4 more sources

Simultaneously blocking ANGPTL3 and CD47 prevents the progression of atherosclerosis through regulating lipid metabolism, macrophagic efferocytosis and lipid peroxidation

Pharmacological Research
Atherosclerosis (AS) ultimately cause major adverse cardiovascular events (MACEs). While traditional strategies by lipid-reducing have reduced MACEs, many patients continue to face significant risks.
Xiaozhi Hu, Yanyang Nan, Yuting Zhang, Jiajun Fan, Hanqi Wang, Yu Bai, Yuanzhen Zhang, Xuyao Zhang, Zeguo Zhu, Zhonglian Cao, Xiaomiao Ye, Tao Wu, Shuwen Xu, Zhengyu Wu, Wei Hu, Dianwen Ju   +15 more
doaj   +1 more source

ANGPTL3 and Cardiovascular Outcomes in Patients With Acute Coronary Syndrome and Obstructive Sleep Apnea

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background The aim of this prospective study was to determine the impact of elevated ANGPTL3 (angiopoietin‐like protein 3) on cardiovascular events (CVEs) following acute coronary syndrome (ACS) in patients with or without obstructive sleep apnea (OSA ...
Qianwen Lv, Xiaolu Jiao, Huahui Yu, Qiuju Sun, Fan Li, Yu Wang, Haili Sun, Zhiyong Du, Linyi Li, Chaowei Hu, Ming Zhang, Shaoping Nie, Yanwen Qin   +12 more
doaj   +1 more source

Gene expression patterns of insulin-like growth factor 1, insulin-like growth factor 2 and insulin-like growth factor binding protein 3 in human placenta from pregnancies with intrauterine growth restriction [PDF]

, 2011
Introduction: In this study, we compared insulin-like growth factor (IGF)-gene expression patterns and characteristics of glucose and insulin metabolism in human placenta from pregnancies with or without intrauterine growth restriction (IUGR).
Tóth, Katalin, Börzsönyi Balázs, Demendi Csaba, Balázs Börzsönyi, Börzsönyi, Balázs, Tóth Katalin, János Rigó Jr, Pajor, Attila, Rigó, János, Joó József, Gábor, Zsolt Nagy, Csaba Demendi, Rigó János, Pajor Attila, Mónika Csanád, Katalin Tóth, Demendi, Csaba, Csanád, Mónika, Nagy, Zsolt, Attila Pajor, József Gábor Joó, Nagy Zsolt, Csanád Mónika, Joó József Gábor   +23 more
core   +1 more source

Angiopoietin-like Protein 3 Mediates Hypertriglyceridemia Induced by the Liver X Receptor [PDF]

Journal of Biological Chemistry, 2003
The KK/San obese and diabetic mouse, a mutant strain from KK obese mice, exhibits significantly low plasma triglyceride levels. In KK/San mice, genetic analysis identified a mutation in the gene encoding angiopoietinlike protein 3 (Angptl3), a liver-specific secretory protein, which had suppressive effect on lipoprotein lipase activity.
Toshimori, Inaba, Morihiro, Matsuda, Mitsuru, Shimamura, Norihide, Takei, Naoki, Terasaka, Yosuke, Ando, Hiroaki, Yasumo, Ryuta, Koishi, Makoto, Makishima, Iichiro, Shimomura   +9 more
openaire   +2 more sources

Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats

, 2003
Angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) have been identified as ligands with different effector functions of the vascular assembly and maturation-mediating receptor tyrosine kinase Tie-2.
Weiss, C, Koblizek, T., Marme, D., Augustin, HG, Augustin, H. G., Fiedler, U, Krissl, T., Martiny-Baron, G., Krissl, T, Koidl, S., Martiny-Baron, G, Deutsch, U, Fiedler, U., Weiss, C., Deutsch, U., Koidl, S, Koblizek, T, Marmé, D   +17 more
core   +1 more source

Modulation of Phosducin-Like Protein 3 (PhLP3) Levels Promotes Cytoskeletal Remodelling in a MAPK and RhoA-Dependent Manner [PDF]

, 2011
Background Phosducin-like protein 3 (PhLP3) forms a ternary complex with the ATP-dependent molecular chaperone CCT and its folding client tubulin. In vitro studies suggest PhLP3 plays an inhibitory role in ?-tubulin folding while conversely in vivo ...
C Mark Smales, Nandini V. L. Hayes, Hayes, Nandini V. L., Hayes Nandini V. L., C. Mark Smales, Carden Martin J., Martin J. Carden, Smales, Christopher Mark, Nandini V L Hayes, Carden, Martin J., Lyne Jossé, Smales C. Mark, Jossé Lyne, Jossé, Lyne, Martin J Carden   +14 more
core   +1 more source