Results 41 to 50 of about 27,286 (132)

Targeting ANGPTL3 by GalNAc-conjugated siRNA ANGsiR10 lowers blood lipids with long-lasting and potent efficacy in mice and monkeys

Molecular Therapy: Nucleic Acids, 2023
Angiopoietin-like protein 3 (ANGPTL3) is an important regulator of lipoproteins by inhibiting both lipoprotein and endothelial lipases. It has been intensively investigated as a drug target for the treatment of dyslipidemia.
Jue Wang, Wen Zheng, Shuquan Zheng, Ye Yuan, Wei Wen, Weiyi Cui, Lifang Xue, Xueting Sun, Haibao Shang, Hongyan Zhang, Rui-Ping Xiao, Shan Gao, Xiuqin Zhang   +12 more
doaj   +1 more source

Quantitation of serum angiopoietin-like proteins 3 and 4 in a Finnish population sample [PDF]

Journal of Lipid Research, 2010
We have developed and validated quantitative ELISAs for human angiopoietin-like (ANGPTL)3 and 4 and correlated their serum levels with parameters of lipid and carbohydrate metabolism. For this study, we used a random subsample of the Health 2000 Health Examination Survey consisting of 125 men and 125 women, aged 30-94 years.
Robciuc, Marius R., Tahvanainen, Esa, Jauhiainen, Matti, Ehnholm, Christian   +3 more
openaire   +4 more sources

Angiopoietin-like protein 8 differentially regulates ANGPTL3 and ANGPTL4 during postprandial partitioning of fatty acids[S]

Journal of Lipid Research, 2020
Angiopoietin-like protein (ANGPTL)8 has been implicated in metabolic syndrome and reported to regulate adipose FA uptake through unknown mechanisms. Here, we studied how complex formation of ANGPTL8 with ANGPTL3 or ANGPTL4 varies with feeding to regulate
Yan Q. Chen, Thomas G. Pottanat, Robert W. Siegel, Mariam Ehsani, Yue-Wei Qian, Eugene Y. Zhen, Ajit Regmi, William C. Roell, Haihong Guo, M. Jane Luo, Ruth E. Gimeno, Ferdinand van't Hooft, Robert J. Konrad   +12 more
doaj   +1 more source

ANGPTL3 and Cardiovascular Outcomes in Patients With Acute Coronary Syndrome and Obstructive Sleep Apnea

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background The aim of this prospective study was to determine the impact of elevated ANGPTL3 (angiopoietin‐like protein 3) on cardiovascular events (CVEs) following acute coronary syndrome (ACS) in patients with or without obstructive sleep apnea (OSA ...
Qianwen Lv, Xiaolu Jiao, Huahui Yu, Qiuju Sun, Fan Li, Yu Wang, Haili Sun, Zhiyong Du, Linyi Li, Chaowei Hu, Ming Zhang, Shaoping Nie, Yanwen Qin   +12 more
doaj   +1 more source

Angiopoietin-like Protein 3 Mediates Hypertriglyceridemia Induced by the Liver X Receptor [PDF]

Journal of Biological Chemistry, 2003
The KK/San obese and diabetic mouse, a mutant strain from KK obese mice, exhibits significantly low plasma triglyceride levels. In KK/San mice, genetic analysis identified a mutation in the gene encoding angiopoietinlike protein 3 (Angptl3), a liver-specific secretory protein, which had suppressive effect on lipoprotein lipase activity.
Toshimori, Inaba, Morihiro, Matsuda, Mitsuru, Shimamura, Norihide, Takei, Naoki, Terasaka, Yosuke, Ando, Hiroaki, Yasumo, Ryuta, Koishi, Makoto, Makishima, Iichiro, Shimomura   +9 more
openaire   +2 more sources

Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase

Journal of Lipid Research, 2002
Studies with KK/San, obese and diabetic model mice having a unique hypotriglyceridemia phenotype, revealed that angiopoietin-like protein 3 (ANGPTL3) regulates lipid metabolism in mice.
Kenichi Yoshida, Tetsuya Shimizugawa, Mitsuru Ono, Hidehiko Furukawa   +3 more
doaj   +1 more source

Angiopoietin-like Protein 3 AND Cardiovascular Disease: A Mini Review

Journal of Pharmaceutical Research International, 2021
Objective of the review is to explore the role of angiopoietin like 3 protein (ANGPTL3) as a risk factor for cardiovascular disease. ANGPTL3 (human), one member of the angiopoietin-like protein (ANGPTL) family, has been identified as an important regulator of lipid metabolism.
openaire   +2 more sources

Metreleptin therapy lowers plasma angiopoietin-like protein 3 in patients with generalized lipodystrophy. [PDF]

J Clin Lipidol, 2017
Reduced triglyceride clearance due to impaired lipoprotein lipase-mediated lipolysis contributes to severe hypertriglyceridemia in lipodystrophy. Angiopoietin-like protein 3 (ANGPTL3) and 4 (ANGPTL4) impair clearance of triglycerides by inhibiting lipoprotein lipase.
Muniyappa R, Abel BS, Asthana A, Walter MF, Cochran EK, Remaley AT, Skarulis MC, Gorden P, Brown RJ.   +8 more
europepmc   +4 more sources

Angiopoietin 1 influences ischemic reperfusion renal injury via modulating endothelium survival and regeneration

Molecular Medicine, 2019
Background Damage to the endothelium due to ischemia reperfusion injury (IRI) leads to a disruption of the microvasculature, which could be influenced by angiopoietin 1 via its effects on endothelium.
Wen-Chih Chiang, Yu-Chin Huang, Ten-I Fu, Ping-Min Chen, Fan-Chi Chang, Chun-Fu Lai, Vin-Cent Wu, Shuei-Liong Lin, Yung-Ming Chen   +8 more
doaj   +1 more source

Local delivery of USC-derived exosomes harboring ANGPTL3 enhances spinal cord functional recovery after injury by promoting angiogenesis

Stem Cell Research & Therapy, 2021
Background Spinal cord injury is a devastating clinical condition for which there are currently no effective therapeutic options. In the present study, we aim to investigate if the effect of an administered injection of exosomes derived from human urine ...
Yong Cao, Yan Xu, Chunyuan Chen, Hui Xie, Hongbin Lu, Jianzhong Hu   +5 more
doaj   +1 more source