Results 21 to 30 of about 24,454,690 (224)

Inhibition of Angiopoietin-Like Protein 3 With a Monoclonal Antibody Reduces Triglycerides in Hypertriglyceridemia. [PDF]

Circulation, 2019
Background: Hypertriglyceridemia is associated with increased cardiovascular risk and may be caused by impaired lipoprotein clearance. Angiopoietin-like protein 3 (ANGPTL3) inhibits lipoprotein lipase activity, increasing triglycerides and other lipids.
Ahmad Z, Banerjee P, Hamon S, Chan KC, Bouzelmat A, Sasiela WJ, Pordy R, Mellis S, Dansky H, Gipe DA, Dunbar RL.   +10 more
europepmc   +3 more sources

The Effect of Canagliflozin on High-Density Lipoprotein Cholesterol and Angiopoietin-Like Protein 3 in Type 2 Diabetes Mellitus [PDF]

Journal of Diabetes Research
Background. Diabetes mellitus is often accompanied by dyslipidemia. Sodium-glucose cotransporter-2 (SGLT2) inhibitors, as a novel therapeutic agent for the treatment of type 2 diabetes mellitus (T2DM), have been reported to exert effects on lipid, while ...
Simo Liu, Jing Ke, Xiaotong Feng, Zongwei Wang, Xin Wang, Longyan Yang, Dong Zhao   +6 more
doaj   +2 more sources

The serum levels of angiopoietin‐like protein 3 and 4 in type 2 diabetic patients with and without metabolic syndrome compared to the control group [PDF]

Endocrinology, Diabetes & Metabolism
Introduction ANGPTLs (Angiopoietin‐like proteins) 3 and 4 play an important role in the development of type 2 diabetes. These glycoproteins affect the modulation of glucose and lipid metabolism.
Sharabeh Hezarkhani, Aytekin Hajighaderi, Sara Hosseinzadeh, Naser Behnampour, Gholamreza Veghari, Farshid Fathabadi, Zahra Hesari, Hamid Reza Joshaghani   +7 more
doaj   +2 more sources

Analysis of circulating angiopoietin-like protein 3 and genetic variants in lipid metabolism and liver health: the DiOGenes study [PDF]

Genes & Nutrition, 2018
Background Angiopoietin-like protein 3 (ANGPTL3), a liver-derived protein, plays an important role in the lipid and lipoprotein metabolism. Using data available from the DiOGenes study, we assessed the link with clinical improvements (weight, plasma ...
Anne Lundby Hess, Jérôme Carayol, Trine Blædel, Jörg Hager, Alessandro Di Cara, Arne Astrup, Wim H. M. Saris, Lesli Hingstrup Larsen, Armand Valsesia   +8 more
doaj   +2 more sources

Angiopoietin-like protein 3 blocks nuclear import of FAK and contributes to sorafenib response. [PDF]

Br J Cancer, 2018
Poor drug response of sorafenib is a major challenge which reduces clinical benefit of renal cell carcinoma (RCC) patients. It is therefore of great clinical significance to elucidate the underlying mechanism to restore the therapeutic response to sorafenib.Angiopoietin-like protein 3 (ANGPTL3) protein levels were measured by western blot and ...
Bao Y, Yang F, Liu B, Zhao T, Xu Z, Xiong Y, Sun S, Qu L, Wang L.   +8 more
europepmc   +4 more sources

Metreleptin therapy lowers plasma angiopoietin-like protein 3 in patients with generalized lipodystrophy. [PDF]

J Clin Lipidol, 2017
Reduced triglyceride clearance due to impaired lipoprotein lipase-mediated lipolysis contributes to severe hypertriglyceridemia in lipodystrophy. Angiopoietin-like protein 3 (ANGPTL3) and 4 (ANGPTL4) impair clearance of triglycerides by inhibiting lipoprotein lipase.
Muniyappa R, Abel BS, Asthana A, Walter MF, Cochran EK, Remaley AT, Skarulis MC, Gorden P, Brown RJ.   +8 more
europepmc   +4 more sources

Gene knockdown of angiopoietin-like protein 3 reduces the occurrence and development of thoracic aortic aneurysms [PDF]

Jichu yixue yu linchuang, 2021
Objective To explore the role of angiopoietin-like protein 3 (ANGPTL3) in the development of thoracic aortic aneurysm (TAA) and its possible mechanism. Methods The TAA patients who underwent open surgical repair in Beijing Anzhen Hospital were selected
YU Hua-hui, JIAO Xiao-lu, YANG Yun-yun, LI Fan, SUN Qiu-ju, YU Yu, LYU Qian-wen, QIN Yan-wen
doaj   +1 more source

Broadening the Scope of Dyslipidemia Therapy by Targeting APOC3 (Apolipoprotein C3) and ANGPTL3 (Angiopoietin-Like Protein 3). [PDF]

Arterioscler Thromb Vasc Biol, 2023
Ginsberg HN, Goldberg IJ.
europepmc   +2 more sources

ANGPTL3 affects the metastatic potential and the susceptibility of ovarian cancer cells to natural killer cell-mediated cytotoxicity

Heliyon, 2023
High metastatic potential and resistance to immunotherapy lead to poor survival in patients with ovarian cancer. Angiopoietin-like protein 3 is aberrantly expressed and exerts diverse roles in the progression of several cancers.
Yuxian Wu, Yaqun Zheng, Zhijun Jin
doaj   +1 more source

Angiopoietin-like protein 3 is an indicator of prognosis in esophageal cancer patients. [PDF]

Int J Clin Exp Med, 2015
Angiopoietin-like protein 3 (ANGPTL3) plays an important role in angiogenesis. This study aimed to examine the protein expression of ANGPTL3, and to evaluate its clinical significance in esophageal cancer. ANGPTL3 expression was detected using immunohistochemistry in 98 pairs of esophageal cancer and adjacent non-cancerous tissues.
Zhu L, Jiang L, Wang W, Jia W, Liu F, Jiao X, Zhu X, Bao J, Yu H.   +8 more
europepmc   +2 more sources