Angiopoietin-Like Protein 3 (ANGPTL3) Inhibitors in the Management of Refractory Hypercholesterolemia [PDF]
Clinical Pharmacology: Advances and Applications, 2022 Constantine E Kosmas,1,2 Maria D Bousvarou,3 Andreas Sourlas,3 Evangelia J Papakonstantinou,4 Edilberto Peña Genao,2 Rogers Echavarria Uceta,2 Eliscer Guzman1,2 1Division of Cardiology, Department of Medicine, Montefiore Medical Center, Bronx, NY, USA ...
Kosmas CE +6 more
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Angiopoietin-Like Protein 3 (ANGPTL3) Modulates Lipoprotein Metabolism and Dyslipidemia. [PDF]
Int J Mol Sci, 2021 Dyslipidemia is characterized by increasing plasma levels of low-density lipoprotein-cholesterol (LDL-C), triglycerides (TGs) and TG-rich lipoproteins (TGRLs) and is a major risk factor for the development of atherosclerotic cardiovascular disorders (ASCVDs).
Chen PY +5 more
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Angiopoietin-like protein 3: a novel potential biomarker for nephrotic syndrome in children [PDF]
Frontiers in Pediatrics, 2023 BackgroundAngiopoietin-like 3 (ANGPTL3) is a secretory glycoprotein. It has been demonstrated that ANGPTL3 level was upregulated in minimal change nephrotic syndrome (MCNS) kidney tissues.
Fujie Wen +11 more
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Angiopoietin-like protein 3 markedly enhanced in the hyperlipidemia related proteinuria [PDF]
Lipids in Health and Disease, 2019 Background Angiopoietin-like protein 3(ANGPTL3) is well acknowledged as a key regulator of lipid metabolism. Now, there have not been enough data to explain the mechanism of hyperlipidemia related proteinuria.
Xia Gao +6 more
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Serum Angiopoietin-like Protein 3 Levels Are Associated with Endothelial Function in Patients with Maintenance Hemodialysis [PDF]
Life, 2023 Angiopoietin-like protein 3 (ANGPTL3) plays an important role in lipid and lipoprotein trafficking and metabolism and is positively correlated with cardiovascular disease.
Tzu-Chiang Wu +4 more
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Effects of angiopoietin-like protein 3 deficiency on postprandial lipid and lipoprotein metabolism1[S] [PDF]
Journal of Lipid Research, 2016 The consequences of angiopoietin-like protein 3 (ANGPTL3) deficiency on postprandial lipid and lipoprotein metabolism has not been investigated in humans.
Ilenia Minicocci +14 more
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Positive correlation of the serum angiopoietin-like protein 3 levels with the aortic augmentation index in patients with coronary artery disease [PDF]
Therapeutics and Clinical Risk Management, 2018 Yu-Shan Fu,1,* Ji-Hung Wang,1,2,* Chung-Jen Lee,3 Bang-Gee Hsu1,4 1School of Medicine, Tzu Chi University, Hualien, 2Division of Cardiology, Buddhist Tzu Chi General Hospital, Hualien, 3Department of Nursing, Tzu Chi University of Science and Technology,
Fu YS, Wang JH, Lee CJ, Hsu BG
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Regulation of the angiopoietin-like protein 3 gene by LXR [PDF]
Journal of Lipid Research, 2003 Angiopoietins are members of the vascular endothelial growth factor family. One family member, angiopoietin-like protein 3 (Angpt1111111175), was recently shown to be predominantly expressed in the liver and to play an important role in regulating lipid ...
Rebecca Kaplan +6 more
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Positive correlation of serum angiopoietin-like protein 3 levels with metabolic syndrome in patients with coronary artery disease [PDF]
Tzu Chi Medical Journal, 2022 Objectives: Angiopoietin-like protein 3 (ANGPTL3) regulates triglyceride metabolism by reversibly inhibiting the lipoprotein lipase activity. Metabolic syndrome (MetS) is an independent risk factor for further cardiovascular disease. This study evaluated
Sy-Harn Lian +3 more
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Antisense oligonucleotide–mediated inhibition of angiopoietin-like protein 3 increases reverse cholesterol transport in mice [PDF]
Journal of Lipid Research, 2021 Supported by an abundance of experimental and genetic evidence, angiopoietin-like protein 3 (ANGPTL3) has emerged as a promising therapeutic target for cardiovascular disease. ANGPTL3 is primarily produced by the liver and is a potent modulator of plasma
Thomas A. Bell, III +5 more
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