Regulation of the angiopoietin-like protein 3 gene by LXR [PDF]
Journal of Lipid Research, 2003 Angiopoietins are members of the vascular endothelial growth factor family. One family member, angiopoietin-like protein 3 (Angpt1111111175), was recently shown to be predominantly expressed in the liver and to play an important role in regulating lipid ...
Rebecca Kaplan +6 more
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Angiopoietin-like protein 3 (ANGPTL3) deficiency and familial combined hypolipidemia. [PDF]
J Biomed Res, 2019 Three members of the angiopoietin-like (ANGPTL) protein family-ANGPTL3, ANGPTL4 and ANGPTL8- are important regulators of plasma lipoproteins. They inhibit the enzyme lipoprotein lipase, which plays a key role in the intravascular lipolysis of triglycerides present in some lipoprotein classes.
Tarugi P, Bertolini S, Calandra S.
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High-Serum Angiopoietin-Like Protein 3 Levels Associated with Cardiovascular Outcome in Patients with Coronary Artery Disease [PDF]
International Journal of Hypertension, 2020 Background. Angiopoietin-like protein 3 (ANGPTL3) plays a pivotal role in lipid metabolism and angiogenesis, and there is growing interest regarding the association between ANGPTL3 and coronary artery disease (CAD). This study aims to investigate whether
Ming-Chun Chen +3 more
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Differential regulation and properties of angiopoietin-like proteins 3 and 4 [PDF]
Journal of Lipid Research, 2005 Angiopoietin-like protein 3 and 4 (Angptl3 and Angptl4) are two members of the angiopoietin-like family of proteins. These two closely related proteins have been reported to similarly affect lipid metabolism through their capacity to inhibit lipoprotein ...
Hongfei Ge +6 more
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The serum levels of angiopoietin‐like protein 3 and 4 in type 2 diabetic patients with and without metabolic syndrome compared to the control group [PDF]
Endocrinology, Diabetes & MetabolismIntroduction ANGPTLs (Angiopoietin‐like proteins) 3 and 4 play an important role in the development of type 2 diabetes. These glycoproteins affect the modulation of glucose and lipid metabolism.
Sharabeh Hezarkhani +7 more
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The Effect of Canagliflozin on High-Density Lipoprotein Cholesterol and Angiopoietin-Like Protein 3 in Type 2 Diabetes Mellitus [PDF]
Journal of Diabetes ResearchBackground. Diabetes mellitus is often accompanied by dyslipidemia. Sodium-glucose cotransporter-2 (SGLT2) inhibitors, as a novel therapeutic agent for the treatment of type 2 diabetes mellitus (T2DM), have been reported to exert effects on lipid, while ...
Simo Liu +6 more
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Angiopoietin-like protein 3 promotes preservation of stemness during ex vivo expansion of murine hematopoietic stem cells. [PDF]
PLoS ONE, 2014 Allogeneic hematopoietic stem cell (HSC) transplantations from umbilical cord blood or autologous HSCs for gene therapy purposes are hampered by limited number of stem cells.
Elnaz Farahbakhshian +9 more
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Analysis of circulating angiopoietin-like protein 3 and genetic variants in lipid metabolism and liver health: the DiOGenes study [PDF]
Genes & Nutrition, 2018 Background Angiopoietin-like protein 3 (ANGPTL3), a liver-derived protein, plays an important role in the lipid and lipoprotein metabolism. Using data available from the DiOGenes study, we assessed the link with clinical improvements (weight, plasma ...
Anne Lundby Hess +8 more
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Positive correlation of the serum angiopoietin-like protein 3 levels with the aortic augmentation index in patients with coronary artery disease [PDF]
Therapeutics and Clinical Risk Management, 2018 Yu-Shan Fu,1,* Ji-Hung Wang,1,2,* Chung-Jen Lee,3 Bang-Gee Hsu1,4 1School of Medicine, Tzu Chi University, Hualien, 2Division of Cardiology, Buddhist Tzu Chi General Hospital, Hualien, 3Department of Nursing, Tzu Chi University of Science and Technology,
Fu YS, Wang JH, Lee CJ, Hsu BG
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Broadening the Scope of Dyslipidemia Therapy by Targeting APOC3 (Apolipoprotein C3) and ANGPTL3 (Angiopoietin-Like Protein 3). [PDF]
Arterioscler Thromb Vasc Biol, 2023 Ginsberg HN, Goldberg IJ.
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