Results 191 to 200 of about 75,908 (219)
Some of the next articles are maybe not open access.
Angiopoietin like protein 4 expression is decreased in activated macrophages
Biochemical and Biophysical Research Communications, 2012Angiopoietin like protein 4 (ANGPTL4) inhibits lipoprotein lipase (LPL) activity. Previous studies have shown that Toll-like Receptor (TLR) activation increases serum levels of ANGPTL4 and expression of ANGPTL4 in liver, heart, muscle, and adipose tissue in mice.
Kenneth R, Feingold +4 more
openaire +2 more sources
Knockdown of Angiopoietin-like protein 4 suppresses the development of colorectal cancer
Cellular and Molecular Biology, 2020Colorectal cancer, is the growth of cancer cells in the part of the colon. Angiopeptin is one of the growth factors in the human body that is particularly effective in the regulatory process. In this research, the regulatory role and its mechanism of Angiopoietin-like protein 4 (ANGPTL4) in colorectal cancer (CRC) metastasis, has been studied.
Liqiang, Wen +5 more
openaire +2 more sources
Angiopoietin-like protein 4: A therapeutic target for triglycerides and coronary disease?
Journal of Clinical Lipidology, 2018The angiopoietin-like proteins are a family of proteins that share structural similarities to the angiopoietins. These proteins have been described to play a key role in the regulation of a myriad of physiologic processes, including serving as essential modulators of lipid and glucose metabolism. Angiopoietin-like protein 4 (ANGPTL4) is a key regulator
David S Olshan, Daniel J Rader
exaly +3 more sources
Genetics and regulation of angiopoietin-like proteins 3 and 4
Current Opinion in Lipidology, 2006Lipoprotein lipase activity in a given tissue is the rate limiting step for the uptake of triglyceride-derived fatty acids. Imbalances in the partitioning of fatty acids have major metabolic consequences. Given the central role of lipoprotein lipase in energy metabolism, the discovery of new molecules that affect the activity of lipoprotein lipase ...
openaire +2 more sources
Association of a genetic variant in the angiopoietin-like protein 4 gene with cervical cancer
Pathology - Research and Practice, 2020Cervical cancer is among the most aggressive gynecological tumors and is a consequence of interactions between genetic and epigenetic factors. Several genetic polymorphisms related to cervical cancer have been reported in previous clinical studies. In this study, we aimed to explore the possible relationship between polymorphisms of the ANGPTL4 gene ...
Farzad, Rahmani +8 more
openaire +2 more sources
The acute phase response stimulates the expression of angiopoietin like protein 4
Biochemical and Biophysical Research Communications, 2010The acute phase response is characterized by elevations in serum triglyceride levels due to both an increase in hepatic VLDL production and a delay in the clearance of triglyceride rich lipoproteins secondary to a decrease in lipoprotein lipase (LPL) activity.
Biao, Lu +4 more
openaire +2 more sources
Characterization of the 5′ Regulatory Region of the Mouse Angiopoietin-like Protein 4
Veterinary Research Communications, 2004The 5' regulatory region of the mouse angiopoietin-like protein 4 (mANGPTL4), a remarkably versatile secreted protein responsible for hyperlipidaemia and angiogenesis, was cloned and functionally characterized. Three potential transcriptional start sites were determined by 5'-RACE and found to be at -129, -126 and -118, relative to the translation ...
K, Yoshida +3 more
openaire +2 more sources
Angiopoietin-like protein 3 and 4 expression 4 and their serum levels in hepatocellular carcinoma
Cytokine, 2017Hepatocellular carcinoma (HCC) is the 6th most common cancer and the 3rd leading cause of cancer causing death allover the world. The aim of this research to explore the clinical relevance of blood angiopoietin-like protein-3 (ANGPTL3) and ANGPTL4 expression and their proteins levels as non invasive biomarkers in cirrhotic and HCC patients and their ...
Amal S, El-Shal +3 more
openaire +2 more sources
Angiopoietin-like protein 4 significantly predicts future cardiovascular events in coronary patients
Atherosclerosis, 2014Angiopoietin-like protein 4 (ANGPTL4) has been associated with cardiometabolic disorders including dyslipidemia and atherosclerosis in animal studies; in humans, however, its impact on metabolic traits and cardiovascular risk remains unclear.We examined the association of plasma ANGPTL4 levels with the metabolic syndrome (harmonized consensus ...
Axel Muendlein +2 more
exaly +3 more sources
Insulin downregulates angiopoietin-like protein 4 mRNA in 3T3-L1 adipocytes
Biochemical and Biophysical Research Communications, 2006Angiopoietin-like protein 4 (angptl4) is mainly secreted from adipose tissue and inhibits lipoprotein lipase activity. The expression and plasma levels of angptl4 are increased by fasting. To clarify its regulation in diabetes and metabolic syndrome, we investigated the effect of insulin on angptl4 mRNA expression in 3T3-L1 adipocytes by using ...
Tsutomu, Yamada +4 more
openaire +2 more sources