Results 91 to 100 of about 19,335,566 (141)

Angiopoietin-like protein 4 : health effects, modulating agents and structure-function relationships

, 2012
The angiopoietin-like protein 4 (ANGPTL4/FIAF) has been identified as a multifunctional signal protein. It is produced by a variety of tissues, and secreted into the blood stream in glycosylated, oligomerized, native and cleaved isoforms, to modulate ...
Grootaert, Charlotte, Van de Wiele, Tom, Verstraete, Willy, Vanhoecke, Barbara, Bracke, Marc   +4 more
core   +1 more source

Angiopoietin-like protein 4 and cardiovascular function in COPD

, 2017
Art. e000161, 8 S.INTRODUCTION: The coexistence of chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD) is frequent and might be inter-related through inflammation-related processes reflected by specific markers. Here, we studied
Welte, T., Holz, Olaf, Waschki, Benjamin, Rabe, K.F., Lichtinghagen, R., Watz, H., Magnussen, Helgo, Janciauskiene, S., Kirsten, Anne-Marie, Meyer, T.   +9 more
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Angiopoietin-like 4 prevents metastasis through inhibition of vascular permeability and tumor cell motility and invasiveness. [PDF]

, 2006
Angiopoietin-like 4 (ANGPTL4), a secreted protein of the angiopoietin-like family, is induced by hypoxia in both tumor and endothelial cells as well as in hypoxic perinecrotic areas of numerous cancers.
Mir, Lluis, M., Mir, Lluis,, Monnot, Catherine, Le Jan, Sébastien, Le Coz, Emmanuelle, Philippe, Josette, Connault, Elisabeth, Opolon, Paule, Germain, Stéphane, Corvol, Pierre, Cazes, Aurélie, Galaup, Ariane, Mekid, Halima   +12 more
core   +1 more source

Fasting-induced adipose factor/angiopoietin-like protein 4 as an adipokine

, 2011
The adipose tissue serves as a major endocrine organ by secreting a large number of metabolically and/or immunologically active factors. One of the proteins secreted by adipose and other tissues is fasting-induced adipose factor (FIAF)/ angiopoietin-like
Kersten, Sander
core  

Angiopoietin-like 4 Is a Wnt Signaling Antagonist that Promotes LRP6 Turnover [PDF]

, 2017
Angiopoietin-like 4 (ANGPTL4) is a secreted signaling protein that is implicated in cardiovascular disease, metabolic disorder, and cancer. Outside of its role in lipid metabolism, ANGPTL4 signaling remains poorly understood. Here, we identify ANGPTL4 as
Colozza, Gabriele, Chang, Ling-Shih,, Maria D.J. Benitez, Niehrs, Christof, Christine Dolde, Ling-Shih Chang, Kirsch, Nadine,, Dolde, Christine,, Gabriele Colozza, Andrey Glinka, Christof Niehrs, Benitez, Maria D. J.,, Dolde, Christine, Niehrs, Christof,, Benitez, Maria DJ, Stefan Koch, Colozza, Gabriele,, Glinka, Andrey, Koch, Stefan,, De Robertis, Edward M, Koch, Stefan, Edward M. De Robertis, Kirsch, Nadine, Chang, Ling-Shih, Nadine Kirsch, Glinka, Andrey,, De Robertis, Edward M.,   +26 more
core   +1 more source

ANGPTL4 plays a paradoxical role in gastric cancer through the LGALS7 and Hedgehog pathways

Scientific Reports
Gastric cancer (GC) is a malignant disease worldwide. Angiopoietin-like protein 4 (ANGPTL4) plays a role in pathophysiological processes, including metabolic reprogramming, angiogenesis, proliferation, and metastasis.
Juan Xie, Yukun Li, Tian Zeng, Tingyu Fan, Hanguo Shan, Gangqing Shi, Wenchao Zhou, Juan Zou, Xiaoyong Lei   +8 more
doaj   +1 more source

Expression of angiopoietin-like 4 in human gastric cancer: ANGPTL4 promotes venous invasion [PDF]

There is strong evidence that the angiopoietin family is involved in the regulation of tumour progression, cellular growth and differentiation. Recently, it has been reported that angiopoietin-like 4 (ANGPTL4) in cancer cell promotes the metastatic ...
Taguchi, Takashi, Hirakawa, Hiroshi, Nagayasu, Takeshi, Abe, Kuniko, Nakayama, Toshiyuki, Shibata, Kenichiro   +5 more
core  

Serum hepatokines in dairy cows: periparturient variation and changes in energy-related metabolic disorders

BMC Veterinary Research, 2018
Background During peripartum period, dairy cows are highly susceptible to energy metabolism disorders such as fatty liver and ketosis. Angiopoietin-like protein 4 (ANGPTL4) and fibroblast growth factor 21 (FGF21), known as hepatokines, play important ...
Jianguo Wang, Xiaoyan Zhu, Guanghui She, Yezi Kong, Yazhou Guo, Zhe Wang, Guowen Liu, Baoyu Zhao   +7 more
doaj   +1 more source

Effects of exercise training on ANGPTL3/8 and ANGPTL4/8 and their associations with cardiometabolic traits

Journal of Lipid Research
Angiopoietin-like protein (ANGPTL) complexes 3/8 and 4/8 are established inhibitors of LPL and novel therapeutic targets for dyslipidemia. However, the effects of regular exercise on ANGPTL3/8 and ANGPTL4/8 are unknown.
William G. Hoffmann, Yan Q. Chen, Charles S. Schwartz, Jacob L. Barber, Prasun K. Dev, Riley J. Reasons, Juan S. Miranda Maravi, Bridget Armstrong, Robert E. Gerszten, Günther Silbernagel, Robert J. Konrad, Claude Bouchard, Mark A. Sarzynski   +12 more
doaj   +1 more source

Plasma angiopoietin-like 4 is related to phospholipid transfer protein activity in diabetic and non-diabetic subjects: role of enhanced low grade inflammation

Lipids in Health and Disease, 2018
Background Angiopoietin-like 4 (ANGPTL4) inhibits lipoprotein lipase, whereas phospholipid transfer protein (PLTP) enhances hepatic triglyceride secretion. Both factors may be upregulated by inflammatory pathways.
Eke G. Gruppen, Sander Kersten, Robin P. F. Dullaart   +2 more
doaj   +1 more source