Results 71 to 80 of about 19,335,566 (141)

Method for decreasing blood glucose and improving glucose tolerance using angiopoietin-like protein 4 [PDF]

, 2008
Angiopoietin like protein 4 is a novel circulating protein predominantly expressed in adipose tissue and liver. Several recent studies demonstrated that angiopoietin like protein 4 is the target gene of peroxisome proliferation activators, the agonists ...

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Chronic Exposure to Ochratoxin A Induces Metabolic Dysfunction‐Associated Steatotic Liver Disease‐Like Symptoms and Obesity With Sex‐Specific Effects in Zebrafish

Food Frontiers, Volume 7, Issue 5, September 2026.
Ochratoxin A exposure induced MASLD and obesity in a sex‐specific manner. Disruption in adipocytokine signaling pathway and vitamin D metabolism led to lipid remodeling and obesity in females. However, activation of PPAR signaling pathway and ferroptosis contributed to lipid remodeling and obesity in males.
Meng Li, Chenxi Li, Mengai He, Zhenfeng Liao, Xijiao Song, Yingqiu Mi, Hongtao Zheng, Jiayin Hou, Liezhong Chen   +8 more
wiley   +1 more source

Acute-phase protein alpha1-antitrypsin--a novel regulator of angiopoietin-like protein 4 transcription and secretion

, 2014
Item does not contain fulltextThe angiopoietin-like protein 4 (angptl4, also known as peroxisome proliferator-activated receptor [PPAR]gamma-induced angiopoietin-related protein) is a multifunctional protein associated with acute-phase response.
Marcondes, A.M., Deeg, H.J., Welte, T., Mahadeva, R., Dinarello, C.A., Wrenger, S., Janciauskiene, S., Immenschuh, S., Koczulla, R., Frenzel, E.   +9 more
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Peroxisome Proliferator Activated Receptors and Lipoprotein Metabolism [PDF]

, 2008
Plasma lipoproteins are responsible for carrying triglycerides and cholesterol in the blood and ensuring their delivery to target organs. Regulation of lipoprotein metabolism takes place at numerous levels including via changes in gene transcription.
Kersten, A.H., Sander Kersten
core   +1 more source

High Concentrations of Angiopoietin-Like Protein 4 Detected in Serum from Patients with Rheumatoid Arthritis Can Be Explained by Non-Specific Antibody Reactivity. [PDF]

PLoS ONE, 2017
Angiopoietin-like protein 4 (ANGPTL4) is suggested to be a master regulator of plasma triglyceride metabolism. Our aim was to study whether the previously reported high levels of ANGPTL4 detected in serum from patients with rheumatoid arthritis (RA) by ...
Elena Makoveichuk, Toralph Ruge, Solveig Nilsson, Anna Södergren, Gunilla Olivecrona   +4 more
doaj   +1 more source

Metabolic Syndrome: From Mechanisms to Therapeutic Interventions

MedComm, Volume 7, Issue 9, September 2026.
A comprehensive overview of molecular mechanisms delves into the potential disease mechanisms of metabolic syndrome, including complex mechanisms such as insulin resistance, chronic low‐grade inflammation, oxidative stress, and epigenetic modifications, and how these mechanisms contribute to the development of metabolic syndrome. Here, the relationship
Mengyao Yan, Qian Xiang
wiley   +1 more source

The role of angiopoietin-like 4 (ANGPTL4) in chemoresistance and autophangy during epithelial-mesenchymal transition (EMT)

, 2019
Patients with metastatic cancers often displayed multidrug resistance (MDR) and emerging studies have shown that the Angiopoietin-like 4 (ANGPTL4) protein plays critical roles in metastatic dissemination of cancer cells during epithelial-mesenchymal ...
Lim, Maegan Miang Kee
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T266M variants of ANGPTL4 improve lipid metabolism by modifying their binding affinity to acetyl-CoA carboxylase in obstructive sleep apnea

Annals of Medicine
Background Angiopoietin-like protein 4 (ANGPTL4) is recognized as a crucial regulator in lipid metabolism. Acetyl-CoA carboxylases (ACACAs) play a role in the β-oxidation of fatty acids.
Xinyi Li, Chenyang Li, Wenjun Xue, Zhicheng Wei, Hangdong Shen, Kejia Wu, Huaming Zhu, Huajun Xu, Xiaolin Wu, Hongliang Yi, Jian Guan, Shankai Yin   +11 more
doaj   +1 more source

RNA‐Binding Proteins: Function, Biological Mechanisms, and Therapeutic Opportunities

MedComm, Volume 7, Issue 9, September 2026.
RNA‐binding proteins (RBPs) regulate RNA stability, localization, translation, and splicing through intrinsic binding domains and interactions with diverse cellular partners. Their competitive and cooperative networks shape disease‐related RNA programs, especially in cancer.
Ling Li, Xiuli Yan, Qing Ji, Hui Zhang
wiley   +1 more source

Angiopoietin-like protein and lipid metabolism

, 2009
Lipoprotein lipase, hepatic lipase, and endothelial lipase play a pivotal role in the clearance and remodelling of plasma lipoproteins. Their activity is governed at the level of gene transcription as well as via changes in enzyme activity by specific ...
Kersten, A.H.
core   +1 more source