Results 91 to 100 of about 96,838 (221)

Fighting obesity by targeting factors regulating beige adipocytes. [PDF]

, 2018
Purpose of reviewThe current review provides an update on secreted factors and mechanisms that promote a thermogenic program in beige adipocytes, and their potential roles as therapeutic targets to fight obesity.Recent findingsWe outline recent studies ...
Koliwad, Suneil K, McQueen, Allison E, Wang, Jen-Chywan   +2 more
core   +1 more source

Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression [PDF]

, 2012
Endothelial Wnt/β-catenin signaling is necessary for angiogenesis of the central nervous system and blood–brain barrier (BBB) differentiation, but its relevance for glioma vascularization is unknown. In this study, we show that doxycycline-dependent Wnt1
Abramsson, Adams, Aicher, Armulik, Arosarena, Augustin, Benedito, Bergers, Blouw, Brastianos, Cancer Genome Atlas Research Network, Carmeliet, Cathrin J. Czupalla, Cattelino, Chien, Claxton, Corada, Daneman, Daneman, Devraj, Ernesto Bockamp, Estrach, Fisher, Franco, Gerhardt, Gerhardt, Harada, Harrington, Hellström, Jadranka Macas, Jakobsson, Jenny Zinke, Kamino, Karl H. Plate, Kavi Devraj, Kotliarova, Li, Liebner, Liebner, Liebner, Liebner, Lobov, Lobov, Lucero, Machein, Mailhos, Makoto M. Taketo, Marco Reis, Marcus Fruttiger, McCarty, Min, Nicole Ziegler, Noguera-Troise, Olsson, Phng, Phng, Rosario Heck, Saharinen, Sascha Seidel, Schneider, Segarra, Siekmann, Smadja, Smolich, Sonja Thom, Stefan Liebner, Stefanie Dimmeler, Stenman, Streit, Thomas, Vleminckx, Willert, Williams, Wolburg, Yano, Yano, Yoshio-Hoshino, Zhang, Zhang, Zhou   +79 more
core   +1 more source

Development of a Human 3D Immune‐Competent Neurovascular Model Enabling Time‐Resolved Monitoring of Neuroinflammatory Dynamics and Neuroimmune Interactions

Advanced Science, EarlyView.
Neuroinflammation alters blood–brain barrier integrity and contributes to neurological disorders, yet existing models lack human immune complexity. This study presents a 3D, immune‐responsive platform that reconstructs key neurovascular components and enables real‐time monitoring.
Pavlo Gordiichuk, Jing Bai, Olurotimi A. Bolonduro, Andrew M. Silverman, Robert Madison Green, Jason H. Lasser, Paul W. Fleming, Lishomwa C. Ndhlovu, James F. Saunders, Dmitry Shvartsman   +9 more
wiley   +1 more source

Circulating Angiopoietin-like Protein 8 Is Independently Associated With Fasting Plasma Glucose and Type 2 Diabetes Mellitus [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2014
Angiopoietin-like protein 8 (Angptl8) has recently been introduced as a novel adipokine/hepatokine that promotes pancreatic β-cell proliferation and improves glucose tolerance in mouse models of insulin resistance. However, regulation of Angptl8 in human type 2 diabetes mellitus (T2DM) and renal dysfunction has not been determined.Serum Angptl8 levels ...
T, Ebert, S, Kralisch, A, Hoffmann, A, Bachmann, U, Lössner, J, Kratzsch, M, Blüher, M, Stumvoll, A, Tönjes, M, Fasshauer   +9 more
openaire   +2 more sources

An ANGPTL4-ceramide-protein kinase Cζ axis mediates chronic glucocorticoid exposure-induced hepatic steatosis and hypertriglyceridemia in mice. [PDF]

, 2019
Chronic or excess glucocorticoid exposure causes lipid disorders such as hypertriglyceridemia and hepatic steatosis. Angptl4 (angiopoietin-like 4), a primary target gene of the glucocorticoid receptor in hepatocytes and adipocytes, is required for ...
Cheang, Rachel T, Chen, Tzu-Chieh, Fitch, Mark D, Gray, Nora E, Hellerstein, Marc K, Kanamaluru, Deepthi, Lee, Justin Y, Lee, Rebecca A, Tan, Jenna H, Tsai, Sam L, Wang, Jen-Chywan, Yiv, Nicholas   +11 more
core  

Dexamethasone in glioblastoma multiforme therapy : mechanisms and controversies [PDF]

, 2019
Glioblastoma multiforme (GBM) is the most common and malignant of the glial tumors. The world-wide estimates of new cases and deaths annually are remarkable, making GBM a crucial public health issue.
Luigi Sforna, Maria Cristina D’Adamo, Mario Valentino, Marta Cenciarini, Mauro Pessia, Mauro Pessia, Paolo Rosa, Silvia Belia, Simona Ronchetti   +8 more
core   +2 more sources

ApoA5 lowers triglyceride levels via suppression of ANGPTL3/8-mediated LPL inhibition

Journal of Lipid Research, 2021
: Triglyceride (TG) molecules represent the major storage form of fatty acids, and TG metabolism is essential to human health. However, the mechanistic details surrounding TG metabolism are complex and incompletely elucidated.
Yan Q. Chen, Thomas G. Pottanat, Eugene Y. Zhen, Robert W. Siegel, Mariam Ehsani, Yue-Wei Qian, Robert J. Konrad   +6 more
doaj   +1 more source

Advances in Gastric Cancer Research: Insights Into Carcinogenesis, the Tumor Microenvironment, Metastasis, and Factors Influencing Prognosis

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background The Department of Gastroenterological Surgery at Kumamoto University has maintained a commitment to integrating cutting‐edge clinical practice with fundamental research, particularly concerning malignant diseases of the digestive tract.
Hideo Baba, Takatsugu Ishimoto, Yoshifumi Baba, Hiromitsu Hayashi, Masaaki Iwatsuki   +4 more
wiley   +1 more source

Metabolic syndrome influences cardiac gene expression pattern at the transcript level in male ZDF rats [PDF]

, 2013
Background: Metabolic syndrome (coexisting visceral obesity, dyslipidemia, hyperglycemia, and hypertension) is a prominent risk factor for cardiovascular morbidity and mortality, however, its effect on cardiac gene expression pattern is unclear ...
Csonka, Csaba, Csont, Tamás Bálint, Fekete, Veronika, Ferdinandy, Péter, Gyémánt, Nóra, Kocsis-Fodor, Gabriella, Pipis, Judit, Puskás, László, Szűcs, Gergő, Sárközy, Márta, Zvara, Ágnes   +10 more
core   +3 more sources

A novel fusion protein consisting of anti-ANGPTL3 antibody and interleukin-22 ameliorates diabetic nephropathy in mice

Frontiers in Immunology, 2022
IntroductionThe pathogenic mechanisms of diabetic nephropathy (DN) include podocyte injury, inflammatory responses and metabolic disorders. Although the antagonism of Angiopoietin-like protein 3 (ANGPTL3) can alleviate proteinuria symptoms by inhibiting ...
Qianqian Ma, Xiaozhi Hu, Fangyu Liu, Zhonglian Cao, Lei Han, Kaicheng Zhou, Yu Bai, Yuting Zhang, Yanyang Nan, Qianying Lv, Jia Rao, Tao Wu, Xue Yang, Haidong He, Dianwen Ju, Dianwen Ju, Hong Xu   +16 more
doaj   +1 more source