Results 91 to 100 of about 26,107 (155)

Insights Into the Biological Mechanisms and Multifunctional Health Benefits of Morelloflavone

eFood, Volume 7, Issue 4, August 2026.
Morelloflavone (MF), a biflavonoid from Garcinia and related species, exhibits broad human health benefits through antioxidant, anti‐inflammatory, anticancer, and metabolic regulatory effects. This review highlights its molecular mechanisms, biosynthesis, and emerging roles in chronic disease prevention, emphasizing systems biology and machine learning
Yi Liu, Ziyong Mao, Jesus Simal‐Gandara, Zi Chen, Hui Cao   +4 more
wiley   +1 more source

Molecular mechanism of the effect of angiopoietin-like protein 8 on the proliferation, invasion and migration of placental trophoblasts in preeclampsia. [PDF]

Exp Ther Med, 2020
Wang W, Li X, Ji D.
europepmc   +1 more source

Lycopene Increases Skeletal Muscle Mass by Promoting Myoblast Differentiation

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Lycopene supplementation could increase skeletal muscle mass by promoting myoblast differentiation and muscle protein synthesis. Mechanistic analysis revealed that lycopene could activate ERα, and ERα activation facilitated myogenic differentiation and myotube formation. ABSTRACT Muscle differentiation is a necessary process for the growth, development
Wanxue Wen, Dajiang Ding, Junning Pu, Yong Zhang, Yexia Luo, Jiaxin Du, Daolin Mou   +6 more
wiley   +1 more source

Immunometabolic Dysregulation in Obesity: Integrating Macrophage Polarization, Metabolic Reprogramming, and Gut Microbiota Crosstalk

Immunity, Inflammation and Disease, Volume 14, Issue 8, August 2026.
ABSTRACT Background Obesity is characterized by chronic low‐grade systemic inflammation, in which adipose tissue macrophages (ATMs) play a pivotal role in driving immune and metabolic dysfunction. Objective This review summarizes current evidence on the roles of ATMs in obese adipose tissue and examines how macrophage polarization and metabolic ...
Yuanyuan Li, Jingwei Mao, Yiwen Deng, Xiaobo Ge, Limin Nie, Qun Wang, Ruiqing Wang, Jiarun Zhang, Tianli Lyu, Luopeng Zhao, Lu Liu, Bin Li   +11 more
wiley   +1 more source

The correlations between angiopoietin like 8 and cardiometabolic risk factors in Saudi women with type 2 diabetes mellitus: A pilot study

Diabetes & Vascular Disease Research
Purpose This study examines whether Angiopoietin Like 8 (ANGPTL8) is linked to cardiometabolic risk factors (CMRFs) in Saudi women with type 2 diabetes (T2DM).
Walaa Mohammedsaeed, Dalal Binjawhar
doaj   +1 more source

Lack of Differences in the Pharmacokinetics of Therapeutic Monoclonal Antibodies Between Japanese and Non‐Japanese Individuals

The Journal of Clinical Pharmacology, Volume 66, Issue 8, August 2026.
Abstract Evaluation of the pharmacokinetics (PK) of new drugs in Japanese individuals is regularly requested by the Japanese regulatory agency prior to participation in global clinical trials or for bridging approaches for regulatory approval. However, the need for PK assessments in the Japanese population may be less compelling for monoclonal ...
Paridhi Gupta, Ashish Sharma, Bernd Meibohm   +2 more
wiley   +1 more source

Divergent Atrial Transcriptomic Signatures in Diabetic and Nondiabetic Atrial Fibrillation

Journal of Arrhythmia, Volume 42, Issue 4, August 2026.
Diabetes alters the atrial transcriptome in atrial fibrillation, characterized by enhanced mitochondrial ATP synthesis, suppressed immune and inflammatory pathways, and distinct miRNA expression profiles, suggesting metabolic and epigenetic remodeling of the atrial substrate.
Kenshi Yoshimura, Yuya Kiriake, Hiroki Osanai, Mengyan Wei, Shinichiro Kume, Tatsuki Kurokawa, Masaki Morishima, Ryusuke Suzuki, Shinji Miyamoto, Katsushige Ono   +9 more
wiley   +1 more source

Lymphatic Endothelial Cells in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Lymphatic endothelial cells (LECs) are dynamic regulators of tissue homeostasis and disease remodeling. In the healthy state, LECs coordinate interstitial fluid drainage, intestinal lipid transport, and immune trafficking and tolerance. Across disease settings, however, these same programs become maladaptively reprogrammed, contributing to barrier ...
Du Tang, Wang Lin, Hengyang Liu, Jixin Zhong, Shiliang Li, Xiaoquan Rao   +5 more
wiley   +1 more source

Acoustically Assisted Heterojunction Hydrogel Promotes Angiogenesis and Tissue Regeneration by Modulating the Inflammatory Microenvironment

Rare Metals, Volume 45, Issue 8, August 2026.
ABSTRACT The healing of diabetic chronic wounds is hindered by multiple pathological barriers, including oxidative stress imbalance induced by hyperglycemia, persistent bacterial infection, and impaired neovascular function. This study developed an F127–HA–BiOCl@CeO2 (FHBC) hydrogel dressing with acoustic responsiveness, achieving tissue repair through
Ran Zhao, Yixuan Song, Wencan Zhang, Chen Liu, Xichao Wang, Xinyang Guo, Jiaming Zhang, Zihao Liu, Le Li   +8 more
wiley   +1 more source

ANGPTL8 regulates glucose metabolism in gestational diabetes mellitus mice, and proteomic analysis reveals the PI3K/Akt pathway plays its role in insulin-resistance HepG2 cells

BMC Pregnancy and Childbirth
Background Insulin resistance (IR) is a pivotal determinant in the pathophysiological processes underlying gestational diabetes mellitus (GDM). Angiopoietin-like protein 8 (ANGPTL8) exhibits an ambiguous influence on glucose metabolism in the onset and ...
Xinping Xie, Jianying Yan, Xiaoyun Chen, Lidan He, Jianbo Wu, Lin Lu   +5 more
doaj   +1 more source