Fermented mistletoe extract as a multimodal antitumoral agent in gliomas [PDF]
, 2012 In Europe, commercially available extracts from the white-berry mistletoe (Viscum album L.) are widely used as a complementary cancer therapy. Mistletoe lectins have been identified as main active components and exhibit cytotoxic effects as well as ...
Harter, Patrick Nikolaus +4 more
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c-Jun N-Terminal Kinase in Inflammation and Rheumatic Diseases. [PDF]
, 2012 The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein kinase (MAPK) family and are activated by environmental stress. JNK is also activated by proinflammatory cytokines, such as TNF and IL-1, and Toll-like receptor ligands ...
Firestein, Gary S, Guma, Monica
core +1 more source
SerpinB3 promotes pro-fibrogenic responses in activated hepatic stellate cells [PDF]
, 2017 SerpinB3 is a hypoxia- and hypoxia-inducible factor-2\u3b1-dependent cystein protease inhibitor that is up-regulated in hepatocellular carcinoma and in parenchymal cells during chronic liver diseases (CLD). SerpinB3 up-regulation in CLD patients has been
Albano, Emanuele +16 more
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Frontiers in Molecular Neuroscience, 2018 Angiopoietin-like protein 8 (Angptl8), a recently identified member of the angiopoietin-like protein family (ANGPTLs), is a 22-kDa peptide synthesized in the liver.
Rui Wang +9 more
doaj +1 more source
Journal of Lipid Research, 2022 Triglycerides (TG) are required for fatty acid transport and storage and are essential for human health. Angiopoietin-like-protein 8 (ANGPTL8) has previously been shown to form a complex with ANGPTL3 that increases circulating TG by potently inhibiting ...
Deepa Balasubramaniam +16 more
doaj +1 more source
Three-dimensional co-culture of mesenchymal stromal cells and differentiated osteoblasts on human bio-derived bone scaffolds supports active multi-lineage hematopoiesis in vitro: Functional implication of the biomimetic HSC niche. [PDF]
, 2016 Recent studies have indicated that the hematopoietic stem/progenitor cell (HSPC) niche, consisting of two major crucial components, namely osteoblasts (OBs) and mesenchymal stromal cells (MSCs), is responsible for the fate of HSPCs.
Huang, Xiaobing +4 more
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Aqueous humor adipokine profile of primary open angle glaucoma patients and cataract patients with or without metabolic disorders [PDF]
International Journal of OphthalmologyAIM: To investigate the role of adipokines in primary open angle glaucoma (POAG) by comparing the levels of these molecules in the aqueous humor among POAG patients and cataract patients with or without metabolic disorders.
Zi-Yao Xia +8 more
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Clinical Diabetology, 2023 OBJECTIVE: This study was conducted to reveal the association of ANGPTL8 gene variant (Rs2278426 (C/T)) with metabolic syndrome in a cohort of Egyptian patients.
Talaat Abdel-Fattah Abdel-Aty +4 more
doaj +1 more source
Metabolic Coordination of Pericyte Phenotypes: Therapeutic Implications [PDF]
, 2020 Pericytes are mural vascular cells found predominantly on the abluminal wall of capillaries, where they contribute to the maintenance of capillary structural integrity and vascular permeability. Generally quiescent cells in the adult, pericyte activation
Haas, Tara +2 more
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Impact of oxygen concentration changes on ANGPTL8 expression of human pulmonary artery endothelial cells [PDF]
Jichu yixue yu linchuangObjective To explore the impact of change in oxygen concentration on the expression of angiopoietin-like protein 8 (ANGPTL8) by endothelial cells (HPAECs) of human pulmonary artery, and the role and mechanism of ANGPTL8 in pulmonary hypertension (PH ...
ZHANG Zongli, LI Tao, MA Jingwen, ZHANG Jiaxin, LI Xingchao, XI Shibing
doaj +1 more source