Results 181 to 190 of about 96,838 (221)

Angiopoietin-like protein 8: a multifaceted protein instrumental in regulating triglyceride metabolism

Current Opinion in Lipidology, 2023
Purpose of review The angiopoietin-like (ANGPTL) proteins ANGPTL3 and ANGPTL4 are critical lipoprotein lipase (LPL) inhibitors. This review discusses the unique ability of the insulin-responsive protein ANGPTL8 to regulate triglyceride (TG) metabolism by
Y. Wen, Yan Q. Chen, R. Konrad
semanticscholar   +3 more sources

Angiopoietin-like protein 8 (betatrophin) inhibits hepatic gluconeogenesis through PI3K/Akt signaling pathway in diabetic mice.

Metabolism, 2021
BACKGROUND & AIMS Angiopoietin-like protein 8 (ANGPTL8) is a 198 amino-acid long, novel secreted protein that is mainly expressed in the liver and brown adipose tissues.
Zhicong Zhao, Xia Deng, J. Jia, Li Zhao, Chenxi Wang, Z. Cai, Chang Guo, Ling Yang, Dong Wang, Suxian Ma, Jialiang Deng, Haoxiang Li, Libin Zhou, Z. Tu, Guoyue Yuan   +14 more
semanticscholar   +3 more sources

Circulating micro RNA-223 and angiopoietin-like protein 8 as biomarkers of gestational diabetes mellitus

British Journal of Biomedical Science, 2020
BSTRACT Background Gestational diabetes mellitus (GDM) is a serious health problem associated with both foetal and maternal complications. New biomarkers that can predict or help in the early diagnosis of GDM are needed to minimize the hazards of ...
A. Abdeltawab, M. Zaki, Y. Abdeldayem, A. Mohamed, S. Zaied   +4 more
semanticscholar   +3 more sources

Increased angiopoietin-like protein 8 expression in colorectal carcinoma patients with liver metastasis

Eurasian Journal of Medicine and Oncology
Colorectal cancer (CRC) is the third most common cancer in men and the second most common in women, with a 5-year survival rate. The disease burden of CRC can be exacerbated by a sedentary lifestyle, lack of physical exercise, smoking, and obesity ...
H. Susanto, Adeodatus Yuda Handaya, Arum Linangkung, Wira Eka Putra, Zulqarnain Mohamed, Jerry Dwi Trijoyo Purnomo, Moch Sholeh, Sa’diyatul Rizqie Amaliyah Firdaus   +7 more
semanticscholar   +2 more sources

Evaluation of serum Angiopoietin-like protein 2 (ANGPTL-2), Angiopoietin-like protein 8 (ANGPTL-8), and high-sensitivity C-reactive protein (hs-CRP) levels in patients with gestational diabetes mellitus and normoglycemic pregnant women

The Journal of Maternal-Fetal & Neonatal Medicine, 2021
Objective In the present study, we aimed to investigate the role of the fasting serum levels of Anjiopoetın 2 - like protein (ANGPTL2), Anjiopoetın 8-like protein (ANGPTL8), and high-sensitivity C-reactive protein (hs-CRP) in the etiopathogenesis of ...
Zeynep Şeyhanlı, Ahmet Şeyhanlı, S. Aksun, B. Pamuk   +3 more
semanticscholar   +4 more sources

Plasma insulin is required for the increase in plasma angiopoietin‐like protein 8 in response to nutrient ingestion

Diabetes/Metabolism Research and Reviews, 2023
Plasma levels of angiopoietin‐like protein 8 (ANGPTL8) are regulated by feeding and they increase following glucose ingestion. Because both plasma glucose and insulin increase following food ingestion, we aimed to determine whether the increase in plasma
Mohamed Abu-Farha, Mariam Alatrach, J. Abubaker, I. Al-Khairi, Preethi Cherian, Krisitn Agyin, S. Abdelgani, L. Norton, John M Adams, D. AL-Saeed, E. Al‐Ozairi, R. DeFronzo, F. Al-Mulla, M. Abdul-Ghani   +13 more
semanticscholar   +3 more sources

Angiopoietin-like proteins 3, 4 and 8: regulating lipid metabolism and providing new hope for metabolic syndrome

Journal of Drug Targeting, 2014
Angiopoietin-like proteins (ANGPTLs) are a group of eight proteins that share structural similarity to the members of the angiopoietin protein family. ANGPTL3 plays a vital role in the regulation of the plasma levels of triglyceride and cholesterol, mainly via reversible inhibition of the lipoprotein lipase activity.
Yunchao, Li, Chunbo, Teng
openaire   +4 more sources

High plasma levels of angiopoietin-like protein 8 and cardiovascular events in patients undergoing coronary angiography.

Atherosclerosis, 2023
Y. Momiyama, Y. Kishimoto, Emi Saita, Reiko Ohmori, Kazuo Kondo   +4 more
semanticscholar   +3 more sources

Inhibition of Angiopoietin-Like Protein 3 or 3/8 Complex and ApoC-III in Severe Hypertriglyceridemia

Current Atherosclerosis Reports, 2023
The role of the inhibition of ANGPTL3 in severe or refractory hypercholesterolemia is well documented, less in severe hyperTG. This review focuses on the preclinical and clinical development of ApoC-III inhibitors and ANGPTL3, 4, and 3/8 complex inhibitors for the treatment of severe or refractory forms of hypertriglyceridemia to prevent cardiovascular
Miriam, Larouche, Etienne, Khoury, Diane, Brisson, Daniel, Gaudet   +3 more
openaire   +2 more sources

The Angiopoietin-Like Protein 3 and 8 Complex Interacts with Lipoprotein Lipase and Induces LPL Cleavage

ACS Chemical Biology, 2021
Lipoprotein lipase (LPL) is the key enzyme that hydrolyzes triglycerides from triglyceride-rich lipoproteins. Angiopoietin-like proteins (ANGPTL) 3, 4, and 8 are well-characterized protein inhibitors of LPL. ANGPTL8 forms a complex with ANGPTL3, and the complex is a potent endogenous inhibitor of LPL.
Najia Jin, William F. Matter, Laura F. Michael, Yuewei Qian, Tarun Gheyi, Leticia Cano, Carlos Perez, Celia Lafuente, Howard B. Broughton, Alfonso Espada   +9 more
openaire   +2 more sources