Results 71 to 80 of about 164,168 (220)

Structures of Angptl3 and Angptl4, modulators of triglyceride levels and coronary artery disease

Scientific Reports, 2018
Coronary artery disease is the most common cause of death globally and is linked to a number of risk factors including serum low density lipoprotein, high density lipoprotein, triglycerides and lipoprotein(a).
Ekaterina Biterova, Mariam Esmaeeli, Heli I. Alanen, Mirva Saaranen, Lloyd W. Ruddock   +4 more
doaj   +1 more source

Angiopoietin-like protein 8 promotes apoptosis of vascular smooth muscle cells through activating p53 signaling pathway [PDF]

Jichu yixue yu linchuang
Objective To investigate the mechanism by which angiopoietin-like protein 8 (ANGPTL8) regulates vascular smooth muscle cell (VSMCs) apoptosis. Methods An in vitro abdominal aortic aneurysm cell model was established by stimulating human VSMCs(HUSMCs ...
YU Huahui, DU Zhiyong, JIAO Xiaolu, LYU Qianwen, YANG Yunyun, HAN Lijie, QIN Yanwen
doaj   +1 more source

Reprogramming the Immune Landscape of Inflammatory Breast Cancer

Advanced Science, EarlyView.
Inflammatory breast cancer is the most lethal subtype of breast cancer and is characterized by an immunosuppressive tumor microenvironment (TME) driven by a complex network of immune cells and inflammatory cytokines, contributing to its aggressiveness and treatment challenges. Immune checkpoint inhibitors, either alone or in combination, show potential
Verena Martinez‐Rodriguez, Suguru Ogata, Xiaoping Wang, Naoto T. Ueno   +3 more
wiley   +1 more source

Quality Thresholds for Angiogenesis Under Acoustic Manipulation in Engineered Vascular Tissues

Advanced Science, EarlyView.
Defined biological and physical quality thresholds achieved through acoustic manipulation regulate cellular alignment and spatial organization, promoting self‐assembling vasculature, extracellular matrix deposition, and angiogenic responses, thereby establishing critical acoustic patterning requirements for engineered vascular tissue development in ...
Oscar O'Dwyer Lancaster‐Jones, Russell Quinn, Niloofar Khoshdel Rad, Kilian Paul, Andrea Frank, Daniela F. Duarte Campos   +5 more
wiley   +1 more source

Oligomerization state-dependent hyperlipidemic effect of angiopoietin-like protein 4

Journal of Lipid Research, 2004
Angiopoietin-like protein 4 (Angptl4) is the second member of the angiopoietin-like family of proteins previously shown to increase plasma triglyceride (TG) levels in vivo.
Hongfei Ge, Guoqing Yang, Xinxin Yu, Tiffany Pourbahrami, Cai Li   +4 more
doaj   +1 more source

Advances in Gastric Cancer Research: Insights Into Carcinogenesis, the Tumor Microenvironment, Metastasis, and Factors Influencing Prognosis

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background The Department of Gastroenterological Surgery at Kumamoto University has maintained a commitment to integrating cutting‐edge clinical practice with fundamental research, particularly concerning malignant diseases of the digestive tract.
Hideo Baba, Takatsugu Ishimoto, Yoshifumi Baba, Hiromitsu Hayashi, Masaaki Iwatsuki   +4 more
wiley   +1 more source

Characterisation of Bombyx mori odorant-binding proteins reveals that a general odorant-binding protein discriminates between sex pheromone components [PDF]

, 2009
In many insect species, odorant-binding proteins (OBPs) are thought to be responsible for the transport of pheromones and other semiochemicals across the sensillum lymph to the olfactory receptors (ORs) within the antennal sensilla.
Field, L.M., Pickett, J. A., Dufour, S. G. L., Zhou, J.J., Keep, N. H., Dufour, Samuel, Field, Linda M., He, X., Hooper, A.M., Hooper, A. M., Pickett, John A., Pickett, J.A., He, Xiaoli, Dufour, S., Field, L. M., Keep, Nicholas H., Robertson, G., Robertson, Giles, Zhou, J-J., Hooper, Antony M., Zhou, Jing-Jiang   +20 more
core   +1 more source

Enhancing Meat Quality Through Dietary Fiber: Insights Into the Gut Microbiota‐Derived Short‐Chain Fatty Acids‐Muscle Axis

Animal Research and One Health, EarlyView.
Dietary fiber (DF) modulates meat quality through the gut‐muscle axis by reshaping gut microbiota, improving intestinal integrity, reducing inflammation, and regulating muscle metabolism. These mechanisms influence muscle fiber characteristics and post‐mortem biochemistry, thereby enhancing tenderness, juiciness, color, flavor, and nutritional value of
Zeshan Zulfiqar, Muhammad Arslan Asif, Layla Al‐Mitib, Nabeela Ashiq, Haojie Wang, Yalei Cui, Boshuai Liu, Shucheng Huang, Yinghua Shi   +8 more
wiley   +1 more source

Mining the role of angiopoietin‐like protein family in gastric cancer and seeking potential therapeutic targets by integrative bioinformatics analysis

Cancer Medicine, 2020
Background The indistinctive effects of antiangiogenesis agents in gastric cancer (GC) can be attributed to multifaceted gene dysregulation associated with angiogenesis.
Cheng Tang, Erbao Chen, Ke Peng, Haiwei Wang, Xi Cheng, Yan Wang, Shan Yu, Yiyi Yu, Yuehong Cui, Tianshu Liu   +9 more
doaj   +1 more source

A New Modality in Dyslipidemia Treatment: Antisense Oligonucleotide Therapy

Journal of Lipid and Atherosclerosis, 2022
There are unmet needs for pharmacologic agents beyond current medications, such as statins, to effectively lower low-density lipoprotein cholesterol levels to target goals, especially in patients with very high or extremely high risk.
Kyuho Kim, Sung Hee Choi
doaj   +1 more source