Results 91 to 100 of about 22,958 (190)

Octopus -inspired gelatin-methacrylate scaffolds loaded with hBMSC-derived exosomes promote wound healing by regulating macrophage polarization

Smart Materials in Medicine
Excessive local movement and inflammation are common problems in the process of wound repair, which lead to failure of later repair. In order to solve this problem, inspired by the octopus sucker structure, we successfully developed a photocrosslinked ...
Dong Yan, Guoqi Cao, Shumei Mao, Zehan Shang, Chengde Li, Guangdong Zhou, Xinping Li, Huitang Xia, Yibing Wang   +8 more
doaj   +1 more source

Understanding exosomes in diabetic wound healing

Periodontology 2000, EarlyView.
Abstract Background Diabetic wounds signify a major complication of diabetes mellitus, characterized by chronic inflammation, compromised angiogenesis, and high risk of infection, amputation, and mortality. Contemporary therapies remain limited in efficacy and durability.
Paras Ahmad, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +4 more
wiley   +1 more source

Sepsis in Dogs and Cats—Consensus Definition and Clinical Criteria

Journal of Veterinary Emergency and Critical Care, EarlyView.
ABSTRACT Sepsis is the clinical syndrome that results from the host response to severe or widespread infection and is a frequent cause of death in veterinary critical care settings. Rapid diagnosis aids early treatment initiation, and hence, how sepsis is defined and identified clinically has implications for patient outcomes.
Robert Goggs, Stefano Cortellini, Amy E. DeClue, Massimo Giunti, Kate Hopper, Julie M. Menard, Rodrigo C. Rabelo, Elizabeth A. Rozanski, Claire R. Sharp, Deborah C. Silverstein, Virginia Sinnott‐Stutzman, Giacomo Stanzani, John Bourgeois, Erik Fausak   +13 more
wiley   +1 more source

Lifestyle modification in atrial fibrillation: Mechanisms, phenotypes and ablation outcomes

Experimental Physiology, EarlyView.
Abstract Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia and is associated with significant morbidity, mortality and healthcare utilization. Catheter ablation is increasingly used as a rhythm‐control intervention for patients with symptomatic paroxysmal and persistent AF, yet recurrence rates remain suboptimal.
Konstantinos Grigoriou, Paschalis Karakasis, Panagiotis Theofilis, Konstantinos Pamporis, Panayotis K. Vlachakis, Anastasios Apostolos, Nikolaos Ktenopoulos, Barbara Fyntanidou, Efstratios Karagiannidis, Dimitrios Patoulias, Antonios P Antoniadis, Nikolaos Fragakis   +11 more
wiley   +1 more source

Impact of oral lipid and glucose tolerance tests on the postprandial concentrations of angiopoietin-like proteins (Angptl) 3 and 4. [PDF]

Eur J Nutr, 2022
Schmid A, Belikan H, Höpfinger A, Schäffler A, Karrasch T.   +4 more
europepmc   +1 more source

Unveiling isoleucyl‐tRNA synthetase 2 as a novel driver of breast cancer via β‐catenin pathway activation

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Isoleucyl‐tRNA synthetase 2 (IARS2) stabilizes β‐catenin by reducing its phosphorylation at Ser33/37/Thr41 and ubiquitin‐proteasome degradation, thereby promoting β‐catenin nuclear accumulation and transcriptional activation of downstream targets, including inhibitor of DNA binding 3, lactate dehydrogenase A, and Drosha ribonuclease III.
Xi Yang, Ya Wang, Yanjiao Yi, Yang Yang, Hongjiang Wang   +4 more
wiley   +1 more source

Craniofacial Fracture and Secretome: A Systematic Review

Plastic and Reconstructive Surgery, Global Open
Background:. Restoring normal morphology and function after craniofacial fractures remains a clinical challenge. Tissue engineering, particularly through cell-free approaches using secretome (soluble proteins and extracellular vesicles), has emerged as a
Mendy H. Oley, MD, PhD, Maximillian C. Oley, MD, PhD, Stevy C. Suoth, MD, Hengki Yong, MD, Muhammad Faruk, MD, Vania Sukarno, MD, Deborah Florencia Gunawan, MD   +6 more
doaj   +1 more source

Active Free Radical Cold Atmosphere Plasma Promotes Healing of Diabetes Foot Ulcer: Mechanism and Challenge

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 6, September 2026.
ABSTRACT Background Diabetic foot ulcers (DFUs) have become an important cause of disability and death in patients with diabetes. Traditional therapies are prone to problems such as recurrence and drug resistance, which result in unsatisfactory healing effects for DFUs.
Yiran Wang, Junxiao Zhang, Jinting Yan, Wenhua Bi, Jinlong Ma   +4 more
wiley   +1 more source

Smart Design: Integrating Artificial Intelligence and Gene Editing for Advanced mRNA Therapeutics

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
The challenges of mRNA therapy and the application of artificial intelligence and gene editing in the field of mRNA drugs. ABSTRACT Artificial intelligence (AI) and gene editing are increasingly being applied to the design and evaluation of mRNA therapeutics.
Haixing Shi, Shengbin Liu, Danni Dai, Shanhui Jiang, Tingchen Tian, Zhenyi Niu, Zhongzheng Xiang, Chaoyu Zou, Fang Liu, Xue Tang, Xin Jiang, Xiangrong Song   +11 more
wiley   +1 more source

The selective degradation of PDE4B shortform, using a PROTAC, leads to inhibition of several hallmarks of cancer in HCT116 cells

British Journal of Pharmacology, Volume 183, Issue 18, Page 5516-5540, September 2026.
Background and Purpose Colorectal cancer is one of the most prevalent cancers worldwide, and novel precision medicine approaches are rapidly improving patient outcomes. Phosphodiesterase 4B (PDE4B) is a member of an enzyme family (PDE4) that hydrolyses intracellular cAMP to control spatial and temporal signalling cues.
Alina Zorn, John Daniel Pediani, Madihah Hussain, Jiayue Ling, Elaine Brown, Igor Belka, Eduardo Torres, Cathy Swindlehurst, Kyle Chan, David Stirling, George S. Baillie, Yuan Yan Sin   +11 more
wiley   +1 more source