Results 111 to 120 of about 22,958 (190)

Lycopene Increases Skeletal Muscle Mass by Promoting Myoblast Differentiation

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Lycopene supplementation could increase skeletal muscle mass by promoting myoblast differentiation and muscle protein synthesis. Mechanistic analysis revealed that lycopene could activate ERα, and ERα activation facilitated myogenic differentiation and myotube formation. ABSTRACT Muscle differentiation is a necessary process for the growth, development
Wanxue Wen, Dajiang Ding, Junning Pu, Yong Zhang, Yexia Luo, Jiaxin Du, Daolin Mou   +6 more
wiley   +1 more source

Kidney angiopoietin-like protein 4 regulates fibrotic responses in diabetic kidney disease

Frontiers in Pharmacology
The angiopoietin-like (ANGPTL) proteins are now recognized as critical regulators of the harmful changes seen in diabetic kidney disease. Notably, a hyposialylated pro-proteinuric form of ANGPTL4 has been identified as a crucial contributor to fibrosis ...
Swayam Prakash Srivastava, Ajan Vishnu Arora, Mariam Hamed, Adesh Urval, Aashika Dupati, Shangyang Xia, Shota Yoshida, Ken Inoki, Ken Inoki, Ken Inoki   +9 more
doaj   +1 more source

Immunometabolic Dysregulation in Obesity: Integrating Macrophage Polarization, Metabolic Reprogramming, and Gut Microbiota Crosstalk

Immunity, Inflammation and Disease, Volume 14, Issue 8, August 2026.
ABSTRACT Background Obesity is characterized by chronic low‐grade systemic inflammation, in which adipose tissue macrophages (ATMs) play a pivotal role in driving immune and metabolic dysfunction. Objective This review summarizes current evidence on the roles of ATMs in obese adipose tissue and examines how macrophage polarization and metabolic ...
Yuanyuan Li, Jingwei Mao, Yiwen Deng, Xiaobo Ge, Limin Nie, Qun Wang, Ruiqing Wang, Jiarun Zhang, Tianli Lyu, Luopeng Zhao, Lu Liu, Bin Li   +11 more
wiley   +1 more source

Lack of Differences in the Pharmacokinetics of Therapeutic Monoclonal Antibodies Between Japanese and Non‐Japanese Individuals

The Journal of Clinical Pharmacology, Volume 66, Issue 8, August 2026.
Abstract Evaluation of the pharmacokinetics (PK) of new drugs in Japanese individuals is regularly requested by the Japanese regulatory agency prior to participation in global clinical trials or for bridging approaches for regulatory approval. However, the need for PK assessments in the Japanese population may be less compelling for monoclonal ...
Paridhi Gupta, Ashish Sharma, Bernd Meibohm   +2 more
wiley   +1 more source

Divergent Atrial Transcriptomic Signatures in Diabetic and Nondiabetic Atrial Fibrillation

Journal of Arrhythmia, Volume 42, Issue 4, August 2026.
Diabetes alters the atrial transcriptome in atrial fibrillation, characterized by enhanced mitochondrial ATP synthesis, suppressed immune and inflammatory pathways, and distinct miRNA expression profiles, suggesting metabolic and epigenetic remodeling of the atrial substrate.
Kenshi Yoshimura, Yuya Kiriake, Hiroki Osanai, Mengyan Wei, Shinichiro Kume, Tatsuki Kurokawa, Masaki Morishima, Ryusuke Suzuki, Shinji Miyamoto, Katsushige Ono   +9 more
wiley   +1 more source

Lymphatic Endothelial Cells in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Lymphatic endothelial cells (LECs) are dynamic regulators of tissue homeostasis and disease remodeling. In the healthy state, LECs coordinate interstitial fluid drainage, intestinal lipid transport, and immune trafficking and tolerance. Across disease settings, however, these same programs become maladaptively reprogrammed, contributing to barrier ...
Du Tang, Wang Lin, Hengyang Liu, Jixin Zhong, Shiliang Li, Xiaoquan Rao   +5 more
wiley   +1 more source

Angiopoietin-like proteins as therapeutic targets for cardiovascular disease: focus on lipid disorders. [PDF]

Expert Opin Ther Targets, 2020
Morelli MB, Chavez C, Santulli G.
europepmc   +1 more source

Acoustically Assisted Heterojunction Hydrogel Promotes Angiogenesis and Tissue Regeneration by Modulating the Inflammatory Microenvironment

Rare Metals, Volume 45, Issue 8, August 2026.
ABSTRACT The healing of diabetic chronic wounds is hindered by multiple pathological barriers, including oxidative stress imbalance induced by hyperglycemia, persistent bacterial infection, and impaired neovascular function. This study developed an F127–HA–BiOCl@CeO2 (FHBC) hydrogel dressing with acoustic responsiveness, achieving tissue repair through
Ran Zhao, Yixuan Song, Wencan Zhang, Chen Liu, Xichao Wang, Xinyang Guo, Jiaming Zhang, Zihao Liu, Le Li   +8 more
wiley   +1 more source

An ANGPTL8‐AKT2‐mTOR Axis Drives Adipose Senescence and Aging‐Related Functional Decline

Aging Cell, Volume 25, Issue 8, August 2026.
ANGPTL8 increases with age in humans and mice and serves as a key predictor of biological aging and mortality. Adipocyte‐derived ANGPTL8 promotes cellular senescence through AKT2–mTOR signaling, whereas genetic deletion of Angptl8 attenuates adipose tissue aging and extends lifespan.
Yi He, Limeng Pan, WenJun Ping, Chen Meng, Xiaoyu Meng, Yaming Guo, Ranran Kan, Yuxi Xiang, Beibei Mao, Siyi Wang, Danpei Li, Xuefeng Yu   +11 more
wiley   +1 more source

The International Guideline for the Definition, Classification, Diagnosis and Management of Urticaria

Allergy, Volume 81, Issue 8, Page 2582-2632, August 2026.
ABSTRACT This update and revision of the international guideline for urticaria was developed in accordance with the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is an initiative of the Global Allergy and Asthma Excellence Network (GA2LEN) and its Urticaria and ...
Torsten Zuberbier, Zainab AbdulHameed Ansari, Amir H. Abdul Latiff, M. M. Abuzakouk, Maria Socorro Agcaoili‐De Jesus, Rosana C. Agondi, Mona Al‐Ahmad, Abdullah A. Alangari, H. Alhameli, Cesar D. Alonso Bello, Saad Alshareef, Salem Al‐Tamemi, Sabine Altrichter, Humaid Al Wahshi, S. Aquilina, M. Araújo, Rand Arnaout, Riccardo Asero, Barbara Ballmer‐Weber, Christine Bangert, Andrea Bauer, Moshe Ben‐Shoshan, Jonathan A. Bernstein, Carsten Bindslev‐Jensen, Mojca Bizjak, Isabelle Boccon‐Gibod, Hanna Bonnekoh, Laurence Bouillet, Knut Brockow, Zenon Brzoza, M. Bulatović Ćalasan, Adeeb Bulkhi, Thomas Buttgereit, Anette Bygum, Teresa Caballero, Oscar Calderon, R. Campos, Mauro Cancian, Emily Carne, Mary Anne Castor, Inmaculada Cerecedo, T. Çetinarslan, Ivan Cherrez‐Ojeda, N. Chkhikvadze, Herberto J. Chong‐Neto, Karen Choo, George Christoff, Chia‐Yu Chu, K. Ciupka, Niall Conlon, Célia Costa, Timothy J Craig, Paulo Criado, Inna Danilycheva, Razvigor Darlenski, Erika De Arruda Chaves, Laurence de Montjoye, M.‐S. Doutre, Aurelie Du‐Thanh, Didier Ebo, S. Elkhalifa, S. Elmariah, Tariq El‐Shanawany, Luis F. Ensina, Ragip Ertaş, Roberta Fachini Jardim Criado, Marta Ferrer, Silvia Ferrucci, Jie Shen Fok, Daria Fomina, Luz Fonacier, Ghada Fouda, I. Francescantonio, Atsushi Fukunaga, César A. Galvan Calle, Elizabeth Garcia, Krisztian Gáspár, Aslı Gelincik, Songmei Geng, Kiran Godse, Margarida Gonçalo, Maia Gotua, C. Grattan, Martine Grosber, Guillermo Guidos Fogelbach, Mar Guilarte, R. Guillod, Eckard Hamelmann, Jason Hawkes, Koremasa Hayama, Ruben Heuer, Michihiro Hide, Wolfram Hoetzenecker, Naoko Inomata, Hye‐Ryun Kang, Allen P. Kaplan, Alexander Kapp, M. Karam, Alicja Kasperska‐Zajac, Constance H. Katelaris, Aharon Kessel, Maryam Khoshkhui, Brian Kim, Tamar Kinaciyan, Emek Kocatürk, Marta Kolacinska‐Flont, Pavel Kolkhir, George N. Konstantinou, Mitja Kosnik, Dorota Krasowska, Kanokvalai Kulthanan, Muthu S. Kumaran, Izabela Kuprys‐Lipinska, Moisés Labrador, Jose Ignacio Larco, Désirée Larenas‐Linnemann, Elena Latysheva, E. Lazaridou, Philip H. Li, H. Lima, Undine Lippert, Markus Magerl, Michael Makris, João Alves Marcelino, Angelo V. Marzano, Iris Medina, Raisa Meshkova, D. Micallef, Ramzy Mohammed Ali, Charlotte G. Mortz, Melba Munoz, Hanneke N. G. Oude Elberink, Alla Nakonechna, Iman Nasr, Alexander Nast, Elena Netchiporouk, Eustachio Nettis, Sandra Nieto, Isabel Ogueta Canales, T.‐L. Okas, Raquel L. Orfali, Esen Özkaya, Claudio Parisi, A. Pennitz, Ruby Pawankar, Manuel P. Pereira, Jonny Peter, Elena Petkova, P. D. Pigatto, Indrashis Podder, T. Popov, Grzegorz Porebski, Polina Pyatilova, German D. Ramon, Hector A. Ratti Sisa, Marysia Stella Recto, Krista Ress, Katie Ridge, Marc Riedl, Carla Ritchie, Nelson Rosario Filho, Isabel Rosmaninho, Michael Rudenko, Maia Rukhadze, Krzysztof Rutkowski, Vito Sabato, Umit M. Sahiner, Sarbjit Saini, F. Saleh Al Sabbagh, Andac Salman, Fulvio Salvo, Jorge Sanchez, A. Santucci, Sibylle Schliemann, Peter Schmid‐Grendelmeier, Bulent E. Sekerel, Faradiba Serpa, Farrukh Sheikh, J. Sheikh, H. Shendi, Frank Siebenhaar, M. Sonomjamts, Angele Soria, Bernardo Sousa Pinto, Maria Staevska, Petra Staubach, M. Stephan, Katarina Stevanovic, Luca Stingeni, Marcin Stobiecki, Özlem Su Küçük, Gordon Sussman, Andrea Szegedi, Shunsuke Takahagi, Akio Tanaka, Natasa Teovska Mitrevska, Simon Francis Thomsen, Elias Toubi, Fragkiski Tsatsou, Murat Turk, Zahava Vadasz, Anna Valerieva, Solange Valle, Martijn van Doorn, Beatriz Veleiro Perez, Carolina E. Vera Ayala, Christian Vestergaard, Rafael J. Vieira, C. W. Maruta, Bettina Wedi, Ricardo N. Werner, Evelyn Wen Yee Yap, Paraskevi Xepapadaki, Yi‐Kui Xiang, Young‐Min Ye, Patrick Yong, Gil Yosipovitch, Anna Zalewska‐Janowska, Christoph Zeyen, Zuotao Zhao, Martin Metz, Ana M. Giménez‐Arnau   +221 more
wiley   +1 more source