Results 151 to 160 of about 57,083 (310)

Dyslipidaemia, Chronic Kidney Disease and Diabetes Mellitus: A Triple Threat to Cardiovascular Health

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Diabetes mellitus (DM) and chronic kidney disease (CKD) frequently coexist and together create a ‘triple threat’ with dyslipidaemia, enhancing the risk for cardiovascular morbidity and mortality. Diabetic kidney disease (DKD) leads to altered lipid metabolism through insulin resistance, inflammation and oxidative stress resulting in an ...
Ann S. Forrest, Priyanka Majety, Stéphanie B. Mayer, Om P. Ganda   +3 more
wiley   +1 more source

Midtrimester maternal plasma concentrations of angiopoietin 1, angiopoietin 2, and placental growth factor in pregnant women who subsequently develop preeclampsia

, 2009
OBJECTIVE: To compare midtrimester maternal plasma concentrations of angiopoietin 1, angiopoietin 2, and placental growth factor between pregnant women who subsequently develop preeclampsia and those who do not.
Jun, Jong Kwan, Shim, Soon-Sup, Lee, Cha Hee   +2 more
core  

Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis.

Cell, 1996
C. Suri, Pamela F. Jones, Sybill Patan, S. Bartunkova, P. Maisonpierre, S. Davis, Thomas N. Sato, G. Yancopouloš   +7 more
semanticscholar   +1 more source

Retatrutide‐Associated Improvements in Cardiovascular Risk Biomarkers in Adults With Obesity With or Without Type 2 Diabetes

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To further characterise the effects of retatrutide on cardiometabolic risk, lipoprotein and inflammatory biomarkers were assessed post hoc in phase 2 trials of adults with obesity/overweight with or without type 2 diabetes (T2D). Materials and Methods Data were analysed from two randomised, double‐blind, placebo‐controlled phase 2 trials.
Giacomo Ruotolo, Charles Harris, Yanzhu Lin, Jonathan M. Wilson, Valentina Pirro, Kevin L. Duffin, Melissa K. Thomas, Mark L. Hartman, Ciara O' Neill, Tamer Coskun, Zvonko Milicevic, Axel Haupt, Naveed Sattar, Stephen J. Nicholls   +13 more
wiley   +1 more source

Therapies for Cardiovascular‐Kidney‐Liver‐Metabolic Syndrome: Reappraisal of Fibrates

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Cardiovascular disease, chronic kidney disease (CKD), type 2 diabetes mellitus (T2DM), obesity and metabolic dysfunction‐associated steatohepatitis (MASH) frequently coexist and share overlapping pathophysiology, forming the proposed cardiovascular‐kidney‐liver‐metabolic (CKLM) syndrome.
Virginia Anagnostopoulou, Christoforos K. Travlos, Lucas Lage Marinho, Thomas A. Mavrakanas, João Pedro Ferreira, Abhinav Sharma   +5 more
wiley   +1 more source

Angiopoietin2 is associated with coagulation activation and tissue factor expression in extracellular vesicles in COVID-19

Frontiers in Medicine
Coagulation activation in immunothrombosis involves various pathways distinct from classical hemostasis, offering potential therapeutic targets to control inflammation-induced hypercoagulability while potentially sparing hemostasis. The Angiopoietin/Tie2
Mayck Silva Barbosa, Franciele de Lima, Carla Roberta Peachazepi Moraes, Ivanio Teixeira Borba-Junior, Stephany Cares Huber, Irene Santos, Bruna Bombassaro, Sergio San Juan Dertkigil, Anton Ilich, Anton Ilich, Nigel S. Key, Nigel S. Key, Nigel S. Key, Joyce M. Annichino-Bizzacchi, Joyce M. Annichino-Bizzacchi, Fernanda Andrade Orsi, Eli Mansour, Licio A. Velloso, Licio A. Velloso, Erich Vinicius De Paula, Erich Vinicius De Paula   +20 more
doaj   +1 more source

Proteomic Pathways Linking Type 2 Diabetes Genetic Clusters to Cardiovascular Diseases: A Network Mendelian Randomisation Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Genetic clusters related to Type 2 diabetes (T2D) have differential impact on cardiovascular diseases (CVDs), although the underlying mechanisms, such as proteomic perturbation, remain unexplored. We conducted a network Mendelian randomisation (MR) study to identify proteomic mediators linking T2D genetic clusters and CVDs.
Shuang Liao, Gabriel Chun Yin Sung, Yiwen Liang, Chenxi Li, Shiu Lun Au Yeung   +4 more
wiley   +1 more source

Lactobacillus fermentum induces osteoblast differentiation via activation of p38 MAPK

CyTA - Journal of Food
Probiotics demonstrate significant potential in activating osteoblasts through multiple molecular and clinical mechanisms. This study aimed to evaluate the potential of Lactobacillus fermentum for osteoblastic differentiation. L.
See-Hyoung Park
doaj   +1 more source

Dysregulated TIE‐2 expression in Alzheimer's disease: Further considerations on regional specificity and shedding evidence

Brain Pathology, EarlyView.
Shi‐qi Zhang, Meichen Liu
wiley   +1 more source

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source