ABSTRACT Peripheral artery disease (PAD) is a progressive atherothrombotic disorder affecting more than 230 million people worldwide. Conventional animal models of chronic hindlimb ischemia (HLI) are highly invasive, technically challenging, fail to account for anatomical variation, and may not accurately recapitulate progressive PAD pathophysiology ...
Oliver Kitzerow +4 more
wiley +1 more source
Update and review of the current medical and surgical management of sickle cell retinopathy. [PDF]
Ercanbrack CW +4 more
europepmc +1 more source
ABSTRACT Background Cognitive impairment is common in bipolar disorder (BD), but the underlying pathophysiology remains unclear. This systematic review aimed to (1) summarize all literature describing relationships of biofluid biomarkers and cognition in BD and (2) identify which biofluid biomarkers correlate most consistently with cognition in BD ...
Alexandra J. M. Beunders +21 more
wiley +1 more source
Angiopoietin-2 and Growth Differentiation Factor-15 as Predictors of Device-Detected Atrial Fibrillation Burden. [PDF]
Bilgeri V +15 more
europepmc +1 more source
Garadacimab for the long‐term prophylaxis of hereditary angioedema
Summary Hereditary angioedema (HAE), a rare and debilitating disease characterized by recurrent and spontaneous attacks of tissue swelling, has a high unmet therapeutic need, with many patients experiencing insufficient disease control with current prophylactic treatments.
Emel Aygören‐Pürsün +5 more
wiley +1 more source
Increased Expression of Angiopoietin 2 and Tie2 in Rosacea. [PDF]
Kaya A, Saurat JH, Satta N, Kaya G.
europepmc +1 more source
Garadacimab zur Langzeitprophylaxe bei hereditärem Angioödem
Zusammenfassung Das hereditäre Angioödem (Hereditary angioedema, HAE), eine seltene und belastende Erkrankung, die durch rezidivierende und spontane Gewebeschwellungsattacken gekennzeichnet ist, weist einen hohen ungedeckten therapeutischen Bedarf auf, da Patienten unter aktuellen prophylaktischen Behandlungen eine unzureichende Krankheitskontrolle ...
Emel Aygören‐Pürsün +5 more
wiley +1 more source
RAS Inhibitor RMC‐7977 Blocks Vascular Overgrowth of NRASQ61R Mutant Endothelial Cells
ABSTRACT RAS mutations occur in patients with several types of vascular anomalies, but effective treatments remain limited. To address this need, we evaluated the RAS (ON) multi‐selective inhibitor RMC‐7977 in human endothelial cells (ECs) expressing the NRASQ61R mutation found in kaposiform lymphangiomatosis (KLA).
Sara Alharbi +6 more
wiley +1 more source
Glycocalyx biomarkers as early predictors of endotheliopathy in pediatric and young adult hematopoietic stem cell transplantation patients. [PDF]
Uchida K +15 more
europepmc +1 more source
The serum ANGPTL4 level and severe coronary artery calcification: from association to risk prediction using a nomogram. [PDF]
Sun Y +8 more
europepmc +1 more source

