Results 131 to 140 of about 57,083 (310)

ANGPT2 Drives Thyroid Cancer Progression Through PI3K/AKT Signaling and Correlates With Poor Prognosis and Immune Infiltration

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objectives Angiopoietin‐2 (ANGPT2) is known to participate in tumor progression and immune modulation across multiple malignancies. Nevertheless, its expression pattern, prognostic value, and biological function in thyroid cancer (THCA) have not been comprehensively investigated.
Han Chen, Lin Wang, Ji‐Sheng Zhang, Xu‐Dong Yan, Long‐Gang Yu, Yan Jiang   +5 more
wiley   +1 more source

Angiopoietin-1 is required for Schlemm's canal development in mice and humans

, 2017
Primary congenital glaucoma (PCG) is a leading cause of blindness in children worldwide and is caused by developmental defects in 2 aqueous humor outflow structures, Schlemm's canal (SC) and the trabecular meshwork.
Tanna, CE (15667754), Liu, X (15482339), Pasutto, F (15596270), Kizhatil, K (15634853), Kalaydjieva, L (15634868), Young, TL (15536975), Javadiyan, S (15569291), Yanovitch, TL (15634865), Craig, JE (15485495), Alexander Hewitt (14739028), Whisenhunt, KN (15634859), Jin, J (15634892), John, SWM (15667760), Quaggin, SE (15634895), Finzi, S (15634874), Souzeau, E (15553088), Wiggs, JL (15516437), Bradfield, YS (15667757), Azmanov, DN (15634871), Tompson, SW (15634847), David Mackey (14743045), Thomson, BR (15634850), Siggs, OM (15603695), Souma, T (15634844), Onay, T (15667751), Feng, L (15531395)   +25 more
core  

Role of Src in angiopoietin 1-induced capillary morphogenesis of endothelial cells: Effect of chronic hypoxia on Src inhibition by PP2. [PDF]

, 2007
Signal transduction pathways leading to angiopoietin 1 (Ang1)-induced capillary morphogenesis by endothelial cells remain poorly defined. Angiogenic cellular responses by endothelial cells may be modulated in vivo by chronic hypoxia, such as that induced
Kanda, Shigeru, Miyata, Yasuyoshi, Kanetake, Hiroshi   +2 more
core   +1 more source

Real‐World Safety and Effectiveness of Icatibant in Patients With Hereditary Angioedema (HAE): Post‐Marketing Surveillance in Japan

The Journal of Dermatology, EarlyView.
ABSTRACT Hereditary angioedema (HAE) is a rare, autosomal dominant, life‐threatening disease characterized by recurrent attacks of swelling of the face, upper airway, gastrointestinal tract, limbs, and/or genitalia. Genetic mutations of the SERPING1 gene encoding the C1‐inhibitor (C1‐INH) plasma protein are associated with HAE‐C1INH.
Kumiko Hosono, Miyako Hoshino
wiley   +1 more source

Hyperoxia causes miR-34a-mediated injury via angiopoietin-1 in neonatal lungs

Nature Communications, 2017
Hyperoxia-induced acute lung injury (HALI) is a key contributor to the pathogenesis of bronchopulmonary dysplasia (BPD) in neonates, for which no specific preventive or therapeutic agent is available. Here we show that lung micro-RNA (miR)-34a levels are
M. Syed, P. Das, Aishwarya Pawar, Z. Aghai, Anu K. Kaskinen, Zhen W. Zhuang, N. Ambalavanan, Gloria S. Pryhuber, S. Andersson, V. Bhandari   +9 more
semanticscholar   +1 more source

Basophils in Immunity: Activation Pathways, Roles in Allergy and AllergoOncology and Application of the Basophil Activation Test

Allergy, EarlyView.
ABSTRACT Basophils, the least abundant leukocytes, are increasingly recognised as potent immunomodulators. Upon activation, they rapidly release preformed granule‐associated mediators including histamine and lipid mediators such as LTC4, while cytokine production occurs over a longer timescale, contributing to downstream immune responses.
Jitesh Chauhan, Sofia Vlasova, Alicia Chenoweth, Debra H. Josephs, Heather J. Bax, Sophia N. Karagiannis   +5 more
wiley   +1 more source

Assessment of peripheral blood concentration of angiopoietin 1, angiopoietin 2 and Tie-2 (a tyrosine kinase receptor) of patients with goitre treated surgically

, 2011
Introduction: Blood vessel formation by angiogenesis is essential for goitre development. Angiopoietin 1 (Ang-1),angiopoietin 2 (Ang-2) and Tie-2 receptor (rTie-2) are involved in part of angiogenesis.
Krzysztof Kuzdak, Joanna Kalupa, Krzysztof Kołomecki   +2 more
core  

Real‐world incidence and clinical characteristics of intraocular inflammation following intravitreal faricimab therapy: A safety study

Acta Ophthalmologica, EarlyView.
Abstract Purpose To estimate the real‐world incidence of intraocular inflammation (IOI) following intravitreal faricimab injections at a large, highly specialized tertiary centre. Methods Single‐centre, retrospective cohort study with chart review using an electronic injection database and electronic medical records from November 2023 to August 2024 ...
Miklos Schneider, Leyla Turan, Farah Arif, Jakob Bjerager, Oliver Niels Klefter, Carsten Faber, Yousif Subhi, Javad Nouri Hajari   +7 more
wiley   +1 more source

Hormone Receptor‐Dependent Correlations Between Angiopoietins and VEGF‐C in Primary Breast Cancer: Insights Into Lymphangiogenic Biomarkers

Cancer Reports
Background Biomarkers of angiogenesis and lymphangiogenesis have been explored in cancer prognostic models; however, their potential role in assessing local tumor invasiveness remains poorly understood.
Vahid Montazeri, Parisa Varshosaz, Ashraf Fakhrjou, Saeed Pirouzpanah   +3 more
doaj   +1 more source

Serum Angiopoietin-2 Predicts Mortality and Kidney Outcomes in Decompensated Cirrhosis

Hepatology, 2019
Acute kidney injury in decompensated cirrhosis has limited therapeutic options, and novel mechanistic targets are urgently needed. Angiopoietin‐2 is a context‐specific antagonist of Tie2, a receptor that signals vascular quiescence.
A. Allegretti, X. Parada, Guillermo A. Ortiz, Joshua D. Long, Scott Krinsky, Sophia H. Zhao, Bryan C. Fuchs, M. Sojoodi, Dongsheng Zhang, S. Karumanchi, Sahir Kalim, Sagar U. Nigwekar, R. Thadhani, S. Parikh, Raymond T. Chung   +14 more
semanticscholar   +1 more source