Results 121 to 130 of about 57,083 (310)

Regulation of the Pathological Vasculature of Malignant Astrocytomas by Angiopoietin-1

Neoplasia: An International Journal for Oncology Research, 2005
Malignant astrocytomas are the most common and highly vascularized of all primary adult brain tumors. The histopathological hallmarks of malignant astrocytomas are microvascular proliferation and formation of vascular entities, which are referred to as ...
Gelareh Zadeh, Rob Reti, Keyvan Koushan, Qian Baoping, Patrick Shannon, Abhijit Guha   +5 more
doaj   +1 more source

Therapeutic Properties and Underlying Mechanisms of Traditional Chinese Medicine in Managing Rheumatoid Arthritis: An Integrative Review of Clinical and Molecular Findings

Phytotherapy Research, EarlyView.
The translational research framework integrating TCM for RA. The figure outlines a stepwise framework for the modernization and clinical translation of TCM in RA. Part 1 highlights the inheritance and development of TCM theory, including classical medical texts, traditional herbal knowledge, and syndrome differentiation–based treatment principles. Part
Jianting Wen, Jian Liu, Lei Wan, Fanfan Wang, Yang Li   +4 more
wiley   +1 more source

Angiogenin, Angiopoietin-1, Angiopoietin-2, and Endostatin Serum Levels in Inflammatory Bowel Disease

, 2011
Background: Angiogenesis is a complex process, involving a great number of mediators. It is implicated in the pathogenesis of numerous diseases, holding a critical role in inflammatory bowel disease (IBD).
Oikonomou, K. A., Andreas N. Kapsoritakis, Tiaka, E. K., Manolakis, A. C., Fotios D. Tsiopoulos, Spiros P. Potamianos, Kapsoritakis, A. N., Kapsoritaki, A. I., Tsiompanidis, I. A., Konstantinos A. Oikonomou, Tsiopoulos, F. D., Potamianos, S. P., Anastasia I. Kapsoritaki, Anastassios C. Manolakis, Elisavet K. Tiaka, Ilias A. Tsiompanidis   +15 more
core   +1 more source

Angiopoietin-1 deficiency increases tumor metastasis in mice [PDF]

, 2017
BACKGROUND: Angipoietin-1 activation of the tyrosine kinase receptor Tek expressed mainly on endothelial cells leads to survival and stabilization of endothelial cells.
Susan E. Quaggin, Pereira, Beatriz,, Michael, Iacovos P., Pereira, Beatriz, Iacovos P. Michael, Jeansson, Marie,, Volpert, Olga, Beatriz Pereira, Marta Lima, Iacovos, Michael, Marie Jeansson, Volpert, Olga,, Quaggin, Susan E, Quaggin, Susan,, Jeansson, Marie, Martina Orebrand, Iacovos, Michael,, Orebrand, Martina, Lima, Marta,, Quaggin, Susan E., Olga Volpert, Michael, Iacovos P, Orebrand, Martina,, Lima, Marta, Quaggin, Susan   +24 more
core   +2 more sources

Angiopoietin-Tie Signaling Pathway in Endothelial Cells: A Computational Model

iScience, 2019
Summary The angiopoietin-Tie signaling pathway is an important vascular signaling pathway involved in angiogenesis, vascular stability, and quiescence.
Yu Zhang, Christopher D. Kontos, B. Annex, A. Popel   +3 more
semanticscholar   +1 more source

Phytochemicals as Multitarget Therapeutics in Pancreatic Cancer: Mechanisms, Clinical Evidence, and Translational Challenges

Phytotherapy Research, EarlyView.
Pancreatic cancer, particularly pancreatic ductal adenocarcinoma, is aggressive and often diagnosed late, making treatment challenging. This review highlights the potential of phytochemicals, such as curcumin and quercetin, as multitarget agents that influence key carcinogenic pathways. These compounds exhibit anticancer effects by inhibiting processes
Md. Rezaul Islam, Abdur Rauf, F. M. Shourav, Hanan A. Ogaly, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Kamala Badalova, Marcello Iriti   +7 more
wiley   +1 more source

Protective Potentials of Natural Products Against Vascular Dementia: A Comprehensive Review of Experimental Studies

Phytotherapy Research, EarlyView.
ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley   +1 more source

Plasma angiopoietin-2 in clinical acute lung injury [PDF]

, 2012
BackgroundAngiopoietin-2 is a proinflammatory mediator of endothelial injury in animal models, and increased plasma angiopoietin-2 levels are associated with poor outcomes in patients with sepsis-associated acute lung injury.
Matthay, Michael A, Abbott, Jason, Gallagher, Diana, Thompson, B Taylor, Calfee, Carolyn S   +4 more
core   +1 more source

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

Angiopoietin-2 Inhibition Rescues Arteriovenous Malformation in a Smad4 Hereditary Hemorrhagic Telangiectasia Mouse Model

Circulation, 2019
Background: Hereditary hemorrhagic telangiectasia is an autosomal dominant vascular disorder caused by heterozygous, loss-of-function mutations in 4 transforming growth factor beta (TGF&bgr;) pathway members, including the central transcriptional ...
Angela M. Crist, Xing-Hua Zhou, Jone Garai, Amanda R Lee, J. Thoele, C. Ullmer, C. Klein, J. Zabaleta, Stryder M. Meadows   +8 more
semanticscholar   +1 more source