Results 101 to 110 of about 57,083 (310)

Angiopoietin-2 is associated with albuminuria and microinflammation in chronic kidney disease. [PDF]

PLoS ONE, 2013
Although cardiovascular disease (CVD) is the leading cause of mortality in patients with chronic kidney disease (CKD), the pathophysiology is not thoroughly understood. Given that elevated albuminuria or circulating angiopoietin-2 associates with CVD and
Fan-Chi Chang, Tai-Shuan Lai, Chih-Kang Chiang, Yung-Ming Chen, Ming-Shiou Wu, Tzong-Shinn Chu, Kwan-Dun Wu, Shuei-Liong Lin   +7 more
doaj   +1 more source

Angiopoietin-2 exacerbates cardiac hypoxia and inflammation after myocardial infarction

Journal of Clinical Investigation, 2018
Emerging evidence indicates that angiopoietin-2 (Angpt2), a well-recognized vascular destabilizing factor, is a biomarker of poor outcome in ischemic heart disease. However, its precise role in postischemic cardiovascular remodeling is poorly understood.
Seung-Jun Lee, Choong-kun Lee, Seok-Min Kang, Intae Park, Yoo Hyung Kim, Seo Ki Kim, S. Hong, Hosung Bae, Yulong He, Y. Kubota, G. Koh   +10 more
semanticscholar   +1 more source

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source

Angiopoietin-2-Induced Arterial Stiffness in CKD

, 2017
The mechanism of vascular calcification in CKD is not understood fully, but may involve collagen deposition in the arterial wall upon osteo/chondrocytic transformation of vascular smooth muscle cells (VSMCs).
Chang, Fan-Chi;Chiang, Wen-Chih;Tsai, Ming-Hsuan;Chou, Yu-Hsiang;Pan, Szu-Yu;Chang, Yu-Ting;Yeh, Pei-Ying;Chen, Yi-Ting;Chiang, Chih-Kang;Chen, Yung-Ming;Chu, Tzong-Shinn;Wu, Kwan-Dun;Lin, Shuei-Liong, 朱宗信;陳永銘;姜文智;姜至剛;吳寬墩;林水龍   +1 more
core   +1 more source

New insights into angiopoietin-like proteins in lipid metabolism and cardiovascular disease risk

Current Opinion in Lipidology, 2019
Purpose of review The angiopoietin-like proteins (ANGPTLs), consisting of ANGPTL3, ANGPTL4, and ANGPTL8, have gained significant interest for their role as inhibitors of lipoprotein lipase (LPL) and for their potential as therapeutic targets for ...
S. Kersten
semanticscholar   +1 more source

Expression of angiopoietin-like 4 in human gastric cancer: ANGPTL4 promotes venous invasion [PDF]

, 2010
There is strong evidence that the angiopoietin family is involved in the regulation of tumour progression, cellular growth and differentiation. Recently, it has been reported that angiopoietin-like 4 (ANGPTL4) in cancer cell promotes the metastatic ...
Taguchi, Takashi, Hirakawa, Hiroshi, Nagayasu, Takeshi, Abe, Kuniko, Nakayama, Toshiyuki, Shibata, Kenichiro   +5 more
core  

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Circulating serum levels of angiopoietin-1 and angiopoietin-2 in nasopharynx and larynx carcinoma patients

, 2016
We aimed to determine the serum levels of angiogenic factors, namely angiopoietins, in nasopharyngeal and laryngeal carcinoma patients. We also aimed to seek the relation of these molecules with tumor grade and their utility as diagnostic biomarkers.
Serilmez, Murat, Karadeniz, Ahmet, Soydinc, Hilal Oguz, Yasasever, Vildan, Guveli, Murat Emin, Duranyildiz, Derya, Bilgin, Elif   +6 more
core   +1 more source

Comparing placentas from normal and abnormal pregnancies [PDF]

, 2010
This report describes work carried out at a Mathematics-in-Medicine Study Group. It is believed that placenta shape villous network characteristics are strongly linked to the placenta’s efficiency, and hence to pregnancy outcome.
Kritz, M., Stechi, A., Siggers, J., Preedy, Katharine, Klika, V., Cotter, SL, Gallimore, L., Greenhalgh, David, Kennedy, S., Whittaker, R., Pu, I., Nelson, P., Heazell, Alexander   +12 more
core   +2 more sources

Future Treatments of Diabetic Retinopathy: Pharmacotherapeutic Products Under Development

European Medical Journal Diabetes, 2017
Diabetic macular oedema (DMO) is the leading cause of vision loss in working aged individuals. Macular laser photocoagulation was the primary DMO treatment for several decades, but has recently been replaced by intravitreal injections of corticosteroids ...
Michael W. Stewart
doaj