Results 91 to 100 of about 57,083 (310)

The Role of Angiopoietin-2 in Post-Burn Pneumonia

European Burn Journal
Background: Pneumonia contributes to post-burn morbidity and mortality. Understanding the mechanisms that predispose burn patients to pneumonia is crucial to both stratifying patients at increased risk and developing targeted interventions.
Mary Grace Murray, Ryan M. Johnson, Abigail B. Plum, Natalia Carbajal Garcia, Kevin E. Galicia, Alexandra Brady, Madison Kipp, Irene B. Helenowski, Madison M. Tschann, Connor Guzior, Richard P. Gonzalez, Mashkoor A. Choudhry, John C. Kubasiak   +12 more
doaj   +1 more source

Regulation of the angiopoietin-like protein 3 gene by LXR

Journal of Lipid Research, 2003
Angiopoietins are members of the vascular endothelial growth factor family. One family member, angiopoietin-like protein 3 (Angpt1111111175), was recently shown to be predominantly expressed in the liver and to play an important role in regulating lipid ...
Rebecca Kaplan, Theresa Zhang, Melba Hernandez, Frank Xiaodong Gan, Samuel D. Wright, M.Gerard Waters, Tian-Quan Cai   +6 more
doaj   +1 more source

Angiopoietins in angiogenesis and beyond

Expert Opinion on Investigational Drugs, 2003
The angiopoietin (Ang) family of growth factors includes four members, all of which bind to the endothelial receptor tyrosine kinase Tie2. Two of the Angs, Ang-1 and Ang-4, activate the Tie2 receptor, whereas Ang-2 and Ang-3 inhibit Ang-1-induced Tie2 phosphorylation.
Tsigkos, S., Koutsilieris, M., Papapetropoulos, A.   +2 more
openaire   +4 more sources

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Boxplot and scatter graphs showing the association between the angiopoietin-2/angiopoietin-1 ratio (A), levels of angiopoietin-2 (B), and levels of angiopoietin-1 (C) with platelet counts in P. vivax malaria patients.

, 2014
Boxplot and scatter graphs showing the association between the angiopoietin-2/angiopoietin-1 ratio (A), levels of angiopoietin-2 (B), and levels of angiopoietin-1 (C) with platelet counts in P. vivax malaria patients.
Cor Jesus Fontes (216797), Clebson Rodrigues-Jesus (638369), Eduardo Rodrigues Alves-Junior (638368), Luciano Teixeira Gomes (638367), Andreia Ferreira Nery (638370), Thamires Oliveira Gasquez-Martin (638371)   +5 more
core   +1 more source

Angiopoietin-1 is associated with cerebral vasospasm and delayed cerebral ischemia in subarachnoid hemorrhage

BMC Neurology, 2011
Background Angiopoietin-1 (Ang-1) and -2 (Ang-2) are keyplayers in the regulation of endothelial homeostasis and vascular proliferation. Angiopoietins may play an important role in the pathophysiology of cerebral vasospasm (CVS). Ang-1 and Ang-2 have not
Pfausler Bettina, Helbok Raimund, Beer Ronny, Dietmann Anelia, Broessner Gregor, Fischer Marlene, Chemelli Andreas, Schmutzhard Erich, Lackner Peter   +8 more
doaj   +1 more source

Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Reducing vascular leakage and stabilizing the endothelium through activation of the angiopoietin (ANGPT)–TIE2 receptor tyrosine kinase pathway is a promising therapeutic strategy for vascular diseases.
Tomokazu Souma, Benjamin R. Thomson, S. Heinen, Isabel Anna Carota, Shinji Yamaguchi, T. Onay, Pan Liu, A. Ghosh, Chengjin Li, V. Eremina, Young-Kwon Hong, A. Economides, D. Vestweber, K. Peters, Jing Jin, S. Quaggin   +15 more
semanticscholar   +1 more source

Angiopoietins and diabetic nephropathy [PDF]

Diabetologia, 2016
Diabetic nephropathy is the main cause of end-stage renal failure in the Western world. In diabetes, metabolic and haemodynamic perturbations disrupt the integrity of the glomerular filtration barrier, leading to ultrastructural alterations of the glomeruli, including podocyte foot process fusion and detachment, glomerular basement membrane thickening,
openaire   +3 more sources

Lean ZSF1 rats in basic research on heart failure with preserved ejection fraction

ESC Heart Failure, Volume 12, Issue 2, Page 1474-1478, April 2025.
Abstract Aims ZSF1 obese rats harbouring two mutant leptin receptor alleles (Leprcp and Leprfa) develop metabolic syndrome and heart failure with preserved ejection fraction (HFpEF), making them a widely used animal model in cardiometabolic research.
Petra Büttner, Antje Augstein, Mahmoud Abdellatif, André Lourenço, Adelino Leite‐Moreira, Inês Falcão‐Pires, Sarah Werner, Holger Thiele, Simon Sedej, Antje Schauer, Volker Adams   +10 more
wiley   +1 more source

Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1.

, 2002
VEGF and Angiopoietin-1 requisitely collaborate during blood vessel development. While Angiopoietin-1 obligately activates its Tie2 receptor, Angiopoietin-2 can activate Tie2 on some cells, while it blocks Tie2 activation on others.
Witte, MH, Witte, C, Campochiaro, PA, Renard, R, Martin, C, Gale, NW, McClain, J, Hackett, SF, Suri, C, Wiegand, SJ, Thurston, G, Yancopoulos, GD, Jackson, D, Wang, Q, Jackson, David   +14 more
core   +1 more source