Results 111 to 120 of about 57,083 (310)

Angiopoietin-like proteins as therapeutic targets for cardiovascular disease: focus on lipid disorders

Expert opinion on therapeutic targets, 2019
Introduction: Angiopoietin-like (ANGPTL) proteins belong to a family of eight secreted factors that are structurally related to proteins that modulate angiogenesi, commonly known as angiopoietins.
M. Morelli, C. Chavez, G. Santulli
semanticscholar   +1 more source

Plasma angiopoietin-1, angiopoietin-2, and angiopoietin receptor tie-2 levels in congestive heart failure

Journal of the American College of Cardiology, 2004
The goal of this research was to test the hypothesis that plasma angiopoietin (Ang-1), its soluble receptor tie-2, and Ang-2 levels would be abnormal in patients with acute and chronic congestive heart failure (CHF) when compared with healthy controls.Increased plasma vascular endothelial growth factor (VEGF) in CHF is suggestive of excess angiogenesis-
Chong, Aun Yeong, Caine, Graham J, Freestone, Bethan, Blann, Andrew D, Lip, Gregory Y.H   +4 more
openaire   +2 more sources

Dissecting the angiogenic mechanism of pachychoroid polypoidal choroidal vasculopathy

iMeta, EarlyView.
A prognosis‐oriented classification system was established to distinguish Pachy PCV from Non‐pachy PCV using a large multicenter dataset. Comparative plasma multi‐omics profiling of Pachy PCV, Non‐pachy PCV, and normal controls revealed unique upregulation of the fluid shear stress and atherosclerosis (FSS‐AS) and HIF‐1 signaling pathways in Pachy PCV.
Xinyu Zhao, Tiantian Cheng, Wenfei Zhang, Xingwang Gu, Qing Zhao, Yaning Chen, Lihui Meng, Jiaqi Zhang, Bintao Qiu, Lili Li, Shiyu Cheng, Zicheng Wang, Chuting Wang, Yuelin Wang, Zuyi Yang, Zhengming Shi, Ye Guo, Shengzhi Liu, Youxin Chen   +18 more
wiley   +1 more source

Validation of a human angiopoietin-2 enzyme linked immunosorbent assay kit for measurement of canine angiopoietin-2 concentrations in plasma and supernatant of primary canine aortic endothelial cell cultures

, 2018
Objective – To assess two human ELISA kits for measurement of angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) in canine plasma and to evaluate the effect of sepsis on plasma Ang-2 concentrations. To isolate and culture primary canine aortic endothelial
Wyder, Marianne, Giger, Urs, Konig, Maya L, König, Maya L., Schuller, Simone, Marti, Eliane, Lettry, Sophie C., Lettry, Sophie C, Mirkovitch, Jelena   +8 more
core   +1 more source

Circulating markers of the endothelial angiopoietin/Tie2 system.

, 2023
Circulating levels of angiopoietin-1 (A), angiopoietin-2 (B), angiopoietin-2/1 ratio (C) and soluble Tie2 (D) in plasma of Tie2+/+ male (white bars), Tie2+/+ female (grey bars), Tie2+/- male (striped white bars) and Tie2+/- female (striped grey bars ...
Anoek L. I. van Leeuwen (8839811), Elise Beijer (17403462), Grietje Molema (64356), Roselique Ibelings (17403465), Matijs van Meurs (358888), Charissa E. van den Brom (3156441), Joris J. T. H. Roelofs (9302018), Nicole A. M. Dekker (10807289), Marjolein R. A. van der Steen (17403468)   +8 more
core   +1 more source

The diagnostic and prognostic value of angiopoietins compared with C-reactive protein and procalcitonin in children with febrile neutropenia

The Turkish Journal of Pediatrics, 2017
In this study, we aimed to determine serum angiopoetin (Ang) levels and compare them with levels of C-reactive protein (CRP) and procalcitonin (PCT).
Esra Mimaroğlu, Elvan Çağlar Çıtak, Necdet Kuyucu, Gülçin Eskendari   +3 more
doaj   +1 more source

Bisphenol A and Its Analogs: Toxicity Analysis in Mouse and Rat Liver—A Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) and its analogs are widely recognized for their use in industry and plastic manufacturing. Consequently, humans and animals are continually exposed to various substances in their daily lives. This review evaluates the hepatic toxicity of BPA and its analogs in mice and rats, with particular emphasis on molecular mechanisms ...
Sevda Bagdatli, Muhammed Canik, Gizem Gencay, Nurbanu Zengin, Tarık Dinc, Nazan Deniz Yön   +5 more
wiley   +1 more source

Angiogenesis‐related gene expression profile in clinical cases of canine cancer

Veterinary Medicine and Science, 2019
The balance between pro‐ and anti‐angiogenic signalling is tightly regulated in normal tissues to maintain the functions of the vasculature. In contrast, the overproduction of angiogenic factors and enhanced angiogenesis are frequently observed in ...
Atsushi Tanabe, Daisuke Kobayashi, Koki Maeda, Masayuki Taguchi, Hiroeki Sahara   +4 more
doaj   +1 more source

Recent Advances in Exosome‐Based Nanodelivery Systems for Traumatic Brain Injury Treatment

Med Research, EarlyView.
An overview of functional modification, therapeutic effects, molecular composition, and delivery strategies for exosomes. ABSTRACT Traumatic brain injury (TBI) is a highly heterogeneous neurological condition with extremely high rates of mortality and disability.
Jue Zhu, Weiquan Liao, Ziqi Lian, Mengdan Zhang, Chenxing Wang, Xingjia Zhu, Lin Zhang, Jian Chen, Zhichao Lu, Peipei Gong   +9 more
wiley   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source