Results 51 to 60 of about 97,507,719 (246)

Refractory kaposiform lymphangiomatosis relieved by splenectomy

Frontiers in Pediatrics, 2023
IntroductionKaposiform lymphangiomatosis (KLA) is a rare and complex lymphatic anomaly with a poor prognosis. There is no standard treatment, and drug therapies are the most common therapeutic method.
Yuru Lan, Jiangyuan Zhou, Tong Qiu, Xue Gong, Yi Ji   +4 more
doaj   +1 more source

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats

, 2003
Angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) have been identified as ligands with different effector functions of the vascular assembly and maturation-mediating receptor tyrosine kinase Tie-2.
Weiss, C, Augustin, HG, Fiedler, U, Krissl, T, Martiny-Baron, G, Deutsch, U, Koidl, S, Koblizek, T, Marmé, D   +8 more
core   +1 more source

The Chemokine CCL4 Stimulates Angiopoietin-2 Expression and Angiogenesis via the MEK/ERK/STAT3 Pathway in Oral Squamous Cell Carcinoma

Biomedicines, 2022
Oral squamous cell carcinoma (OSCC) is a common malignant tumor with a poor prognosis and is a major public health burden in Taiwan. Angiogenesis, the formation of new blood vessels, promotes tumor proliferation, maintenance, and metastasis. Angiopoietin
Chien-Chi Lu, Hsiao-Chi Tsai, Dong-Ying Yang, Shih-Wei Wang, Ming-Hsui Tsai, Chun-Hung Hua, Kwei-Jing Chen, Michael Yuan-Chien Chen, Ming-Yu Lien, Chih-Hsin Tang   +9 more
doaj   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Angiopoietin-2 levels in COVID-19 patients as a marker of endotheliopathy [PDF]

Minia Journal of Medical Research
Background:COVID-19 is described as endothelial disease, endothelial markers in COVID-19 patients could serve as an early indicator of severity of the disease, Angiopoietin -2 is an angiogenesis regulator it is released upon endothelial activation.
Ashraf Osman, Ayman Ghobrial, Martha Mady, Dalia Meshref   +3 more
doaj   +1 more source

Elevated plasma angiopoietin-2 levels and primary graft dysfunction after lung transplantation. [PDF]

PLoS ONE, 2012
INTRODUCTION:Primary graft dysfunction (PGD) is a significant contributor to early morbidity and mortality after lung transplantation. Increased vascular permeability in the allograft has been identified as a possible mechanism leading to PGD ...
Joshua M Diamond, Mary K Porteous, Edward Cantu, Nuala J Meyer, Rupal J Shah, David J Lederer, Steven M Kawut, James Lee, Scarlett L Bellamy, Scott M Palmer, Vibha N Lama, Sangeeta M Bhorade, Maria Crespo, Ejigayehu Demissie, Keith Wille, Jonathan Orens, Pali D Shah, Ann Weinacker, David Weill, Selim Arcasoy, David S Wilkes, Lorraine B Ware, Jason D Christie, Lung Transplant Outcomes Group   +23 more
doaj   +1 more source

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Angiopoietin-1 levels and other baseline parameters as predictors of overall mortality/transplant in patients with different PH subtypes.

, 2016
Angiopoietin-1 levels and other baseline parameters as predictors of overall mortality/transplant in patients with different PH subtypes.
Manuel Jonas Richter (2586910), Natascha Sommer (2586913), Ralph Schermuly (3324684), Thomas Schmidt (168952), Henning Gall (759343), Svenja Lena Tiede (3324687), Werner Seeger (5494), Hossein Ardeschir Ghofrani (142879)   +7 more
core   +1 more source

Correlations behind macrotrabecular‐massive and vessels encapsulating tumor cluster patterns in hepatocellular carcinoma

iRADIOLOGY, 2023
Macrotrabecular‐massive hepatocellular carcinoma (MTM‐HCC) is a subtype of HCC with a very poor prognosis and exhibits biological behaviors and clinical presentations that distinguish it from conventional HCC.
Yong‐Wen Sun, Yu‐Peng Chen, Shi‐Ji Kan, Ya‐Dong Liu, Zhi‐bing Ruan, Bo Gao   +5 more
doaj   +1 more source