Results 71 to 80 of about 97,507,719 (246)

Drug repurposing screen identifies Foxo1-dependent angiopoietin-2 regulation in sepsis [PDF]

, 2015
OBJECTIVE: The recent withdrawal of a targeted sepsis therapy has diminished pharmaceutical enthusiasm for developing novel drugs for the treatment of sepsis.
Rajakumar, Augustine, Schrimpf, Claudia, Maski, Manish R., Ahmed, Asif, Maski, Manish R, Berghelli, Anthony V., Donnino, Michael W, Ghosh, Chandra C., Parikh, Samir M., Kielstein, Jan T, Abid, Tanaz, Milam, Katelyn E., Ghosh, Chandra C, Parikh, Samir M, Thamm, Kristina, Aird, William C., Thickett, David, Milam, Katelyn E, Berghelli, Anthony V, Santel, Ansgar, Haller, Hermann, Wang, Keqin, Donnino, Michael W., David, Sascha, Kielstein, Jan T., Chase, Maureen, Aird, William C   +26 more
core   +1 more source

Circulating markers of the endothelial angiopoietin/Tie2 system.

, 2023
Circulating levels of angiopoietin-1 (A), angiopoietin-2 (B), angiopoietin-2/1 ratio (C) and soluble Tie2 (D) in plasma of Tie2+/+ male (white bars), Tie2+/+ female (grey bars), Tie2+/- male (striped white bars) and Tie2+/- female (striped grey bars ...
Anoek L. I. van Leeuwen (8839811), Elise Beijer (17403462), Grietje Molema (64356), Roselique Ibelings (17403465), Matijs van Meurs (358888), Charissa E. van den Brom (3156441), Joris J. T. H. Roelofs (9302018), Nicole A. M. Dekker (10807289), Marjolein R. A. van der Steen (17403468)   +8 more
core   +1 more source

Enhancing Meat Quality Through Dietary Fiber: Insights Into the Gut Microbiota‐Derived Short‐Chain Fatty Acids‐Muscle Axis

Animal Research and One Health, EarlyView.
Dietary fiber (DF) modulates meat quality through the gut‐muscle axis by reshaping gut microbiota, improving intestinal integrity, reducing inflammation, and regulating muscle metabolism. These mechanisms influence muscle fiber characteristics and post‐mortem biochemistry, thereby enhancing tenderness, juiciness, color, flavor, and nutritional value of
Zeshan Zulfiqar, Muhammad Arslan Asif, Layla Al‐Mitib, Nabeela Ashiq, Haojie Wang, Yalei Cui, Boshuai Liu, Shucheng Huang, Yinghua Shi   +8 more
wiley   +1 more source

Prognostic and Pathogenic Role of Angiopoietin-1 and -2 in Pneumonia

, 2018
RATIONALE: During pneumonia, pathogen-host interaction evokes inflammation and lung barrier dysfunction. Tie2-activation by Angiopoietin-1 reduces, while Tie2-blockade by Angiopoietin-2 increases inflammation and permeability during sepsis.
Norbert Weissmann, Markus Scholz, Mitchell, Tim, Jörg Kaufmann, Weissmann, Norbert, Stefano Aliberti, Neuhauß, Anne-Kathrin, Mitchell, Timothy J, Norbert Suttorp, Aliberti, Stefano, Katrin Reppe, Anne-Kathrin Neuhauß, Ansgar Santel, Timothy J. Mitchell, Santel, Ansgar, Gutbier, Birgitt, Scholz, Markus, Witzenrath, Martin, Suttorp, Norbert, Birgitt Gutbier, Carolin Ehrler, Morawietz, Lars, Stefan Hippenstiel, Martin Witzenrath, Ehrler, Carolin, Hippenstiel, Stefan, Lars Morawietz, Reppe, Katrin, Kaufmann, Jörg   +28 more
core   +1 more source

Association between angiopoietin‐2 and functional cardiac remodeling in hemodialysis patients with normal left ventricular ejection

The Journal of Clinical Hypertension, 2022
Cardiac remodeling is the initial process in heart failure development. The aim of this study is to evaluate the association between endothelium‐related biomarkers and cardiac remodeling in hemodialysis (HD) patients and how the presence of high blood ...
Ana Aécia Alexandrino deOliveira, Thaís Alexandrino deOliveira, Larissa Alexandrino deOliveira, Gdayllon Cavalcante Meneses, Gabriela Freire Bezerra, Alice Maria Costa Martins, Alexandre Braga Libório   +6 more
doaj   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Angiopoietin-2-Induced Arterial Stiffness in CKD

, 2017
The mechanism of vascular calcification in CKD is not understood fully, but may involve collagen deposition in the arterial wall upon osteo/chondrocytic transformation of vascular smooth muscle cells (VSMCs).
Chang, Fan-Chi;Chiang, Wen-Chih;Tsai, Ming-Hsuan;Chou, Yu-Hsiang;Pan, Szu-Yu;Chang, Yu-Ting;Yeh, Pei-Ying;Chen, Yi-Ting;Chiang, Chih-Kang;Chen, Yung-Ming;Chu, Tzong-Shinn;Wu, Kwan-Dun;Lin, Shuei-Liong, 朱宗信;陳永銘;姜文智;姜至剛;吳寬墩;林水龍   +1 more
core   +1 more source

Lean ZSF1 rats in basic research on heart failure with preserved ejection fraction

ESC Heart Failure, Volume 12, Issue 2, Page 1474-1478, April 2025.
Abstract Aims ZSF1 obese rats harbouring two mutant leptin receptor alleles (Leprcp and Leprfa) develop metabolic syndrome and heart failure with preserved ejection fraction (HFpEF), making them a widely used animal model in cardiometabolic research.
Petra Büttner, Antje Augstein, Mahmoud Abdellatif, André Lourenço, Adelino Leite‐Moreira, Inês Falcão‐Pires, Sarah Werner, Holger Thiele, Simon Sedej, Antje Schauer, Volker Adams   +10 more
wiley   +1 more source

Plasma Angiopoietin-1, Angiopoietin-2, Angiopoietin Receptor Tie-2, and Vascular Endothelial Growth Factor Levels in Acute Coronary Syndromes [PDF]

Circulation, 2004
Background— Angiopoietin (Ang) -1 and -2, their receptor Tie-2, and vascular endothelial growth factor (VEGF) regulate angiogenesis and may be important in myocardial collateral development. Elevated levels of growth factors and their receptors are reported in myocardial infarction (MI), but changes ...
Kaeng W, Lee, Gregory Y H, Lip, Andrew D, Blann   +2 more
openaire   +2 more sources

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source