Results 251 to 260 of about 311,072 (299)

Omics GWAS: A Multi‐Omics Integrative Analysis Platform for Genome‐Wide Association Studies

Med Research, EarlyView.
ABSTRACT With the rapid advancement of genome‐wide association studies (GWAS), downstream analyses of GWAS data have become essential for elucidating the genetic mechanisms that underlie complex diseases. However, current post‐GWAS analyses face numerous challenges, including heterogeneous data formats, challenges in multi‐omics integration, and ...
Xu Zhang, Kailai Li, Yasi Zhang, Cenwen Liu, Shunyi Huang, Yingzhao Jin, Yugeng Gao, Quan Cheng, Yunyun Mei   +8 more
wiley   +1 more source

Regulation of vascular angiotensin II type 1 and type 2 receptor and angiotensin-(1-7)/MasR signaling in normal and hypertensive pregnancy. [PDF]

Biochem Pharmacol
Clark CR, Khalil RA.
europepmc   +1 more source

Angiotensin-(1-7) : a member of circulating angiotensin peptides

, 1992
openaire   +1 more source

Angiotensin-(1-7) with Thioether Bridge: An Angiotensin-Converting Enzyme-Resistant, Potent Angiotensin-(1-7) Analog

The Journal of Pharmacology and Experimental Therapeutics, 2009
The in vivo efficacy of many therapeutic peptides is hampered by their rapid proteolytic degradation. Cyclization of these therapeutic peptides is an excellent way to render them more resistant against breakdown. Here, we describe the enzymatic introduction of a thioether ring in angiotensin [Ang-(1-7)], a heptapeptide that plays a pivotal role in the ...
Kluskens, Leon D., Nelemans, S. Adriaan, Rink, Rick, de Vries, Louwe, Meter-Arkema, Anita, Wang, Yong, Walther, Thomas, Kuipers, Anneke, Moll, Gert N., Haas, Marijke   +9 more
openaire   +3 more sources

Therapeutic uses for Angiotensin-(1-7)

Expert Opinion on Therapeutic Patents, 2016
Angiotensin-(1-7) is a key component of the Renin-Angiotensin System, which can counter-regulate several deleterious effects caused by angiotensin II. Due to the potential for therapeutic use, several of its actions are specifically described in patents.In this review, the authors describe a plethora of therapeutic uses for Angiotensin-(1-7), claimed ...
Alice, Machado-Silva, Danielle, Passos-Silva, Robson Augusto, Santos, Rubén Dario, Sinisterra   +3 more
openaire   +3 more sources

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Angiotensin-(1–7): an update

Regulatory Peptides, 2000
The renin-angiotensin system is a major physiological regulator of arterial pressure and hydro-electrolyte balance. Evidence has now been accumulated that in addition to angiotensin (Ang) II other Ang peptides [Ang III, Ang IV and Ang-(1-7)], formed in the limited proteolysis processing of angiotensinogen, are importantly involved in mediating several ...
R A, Santos, M J, Campagnole-Santos, S P, Andrade   +2 more
openaire   +2 more sources

Angiotensin-(1–7) and the renin–angiotensin system

Current Opinion in Nephrology and Hypertension, 2007
In this review we will focus on the recent findings related to angiotensin-(1-7) as an angiotensin II counter-regulatory peptide within the renin-angiotensin system.The identification of the angiotensin-converting enzyme homologue ACE2 as an angiotensin peptide processing enzyme and of Mas as a receptor for angiotensin-(1-7) has contributed to ...
Robson A S, Santos, Anderson J, Ferreira
openaire   +2 more sources

Angiotensin (1-7) and other Angiotensin Peptides

Current Pharmaceutical Design, 2013
In the classical renin angiotensin system (RAS), angiotensin II Ang IIplays many important roles in cardiovascular disease and in kidney, brain, and other organs via the Ang II type 1 receptor (AT1). The RAS consists of many angiotensin peptides, including Ang (1-7), Ang (1-9), Ang (2-8), and Ang IV. Ang (1-7), produced by angiotensin-converting enzyme
Mitsuru, Ohishi, Koichi, Yamamoto, Hiromi, Rakugi   +2 more
openaire   +2 more sources

Angiotensin-(1–7) in the ovine fetus

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2001
In the adult animal, ANG-(1–7) may counterbalance some effects of ANG II. Its effects in the fetus are unknown. Basal ANG-(1–7), ANG I, ANG II, and renin concentrations were measured in plasma from ovine fetuses and their mothers ( n = 10) at 111 days of gestation.
Moritz, KM, Campbell, DJ, Wintour, EM
openaire   +3 more sources

Role of the ACE2/Angiotensin 1–7 Axis of the Renin–Angiotensin System in Heart Failure

Circulation Research, 2016
Heart failure (HF) remains the most common cause of death and disability, and a major economic burden, in industrialized nations. Physiological, pharmacological, and clinical studies have demonstrated that activation of the renin-angiotensin system is a ...
Vaibhav B Patel, Jiu-Chang Zhong
exaly   +2 more sources