Results 181 to 190 of about 206,964 (305)

A Pharmacogenomics‐Guided Antihypertensive Strategy for Blood Pressure Reduction in Rural China: A Cluster‐Randomized Controlled Trial

Health Care Science, EarlyView.
This manuscript reports the findings from the Pharmacogenomic‐guided Antihypertensive Strategy Trial study amidst the deteriorating blood pressure control observed globally during the COVID‐19 pandemic. A pharmacogenomics‐guided strategy achieved a 98.4% blood pressure control rate at 4 weeks in rural China.
Wangjun Qin, Mengke Yu, Ying Zhu, Queran Lin, Limei Yin, Guisheng Liu, Yaping Wang, Guangqiang Lu, Xiaofei Liu, Pengmei Li, Xudong Kong, Li Zhao, Kun Tang, Jiangli Jin, Yu Xiong, Yingnan Zhao, Yan Yan, Bo Li, Azeem Majeed, Xianbo Zuo, Yue Qiu, Jiantuo Yu, Lihong Liu   +22 more
wiley   +1 more source

Expression of angiotensin-converting enzyme 2, transmembrane serine protease 2, and sirtuin 1 proteins in lungs of different age groups. [PDF]

J Bras Pneumol
Lamounier ACA, Froio FCL, Ribeiro Júnior G, Costa NSX, Brito JM, Silva-Filho LVRFD, Mauad T.   +6 more
europepmc   +1 more source

Angiotensin-converting enzyme 2 regulates the placental response to repeated hypoxia-reoxygenation insult. [PDF]

J Physiol
Brooker IA, Sutherland JM, Endacott SK, Lumbers ER, Fisher JJ, Pringle KG.   +5 more
europepmc   +1 more source

Cardiovascular disease incidence and cancer risk in two large European prospective cohorts

International Journal of Cancer, EarlyView.
What's New? Cardiovascular disease (CVD) and cancer share risk factors and biological mechanisms, raising questions about potential associations between the two, particularly regarding CVD duration and cancer onset. Whether CVD influences subsequent cancer risk, however, remains inconclusive.
Emma Fontvieille, Vivian Viallon, Laia Peruchet‐Noray, Quan Gan, N. Charlotte Onland‐Moret, Yvonne Koop, Anne Tjønneland, Nicola Patricia Bondonno, Verena Katzke, Rudolf Kaaks, Matthias B. Schulze, Catarina Schiborn, Calogero Saieva, Vittorio Simeon, Claudia Agnoli, Rosario Tumino, Fulvio Ricceri, Leila Luján‐Barroso, Maria‐José Sánchez, Conchi Moreno‐Iribas, Konstantinos K. Tsilidis, Marc J. Gunter, Adam Butterworth, Elio Riboli, Heinz Freisling, Pietro Ferrari   +25 more
wiley   +1 more source

Exploratory Analysis of Plasma Angiotensin-Converting Enzyme 2 and Angiotensin Peptides as Candidate Discriminatory Signals in Breast Cancer: A Pilot Case-Control Study. [PDF]

Biomedicines
Ghimire B, Giri P, Tavernier S, Hobdey SE, Aghazadeh-Habashi A.   +4 more
europepmc   +1 more source

A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside

Interdisciplinary Medicine, EarlyView.
This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione, Ana Talamillo, Juan M. Falcón‐Pérez   +2 more
wiley   +1 more source

Clinical Significance and Potential Molecular Mechanisms of Angiotensin-Converting Enzyme 2 in Colorectal Cancer. [PDF]

World J Oncol
Zeng DT, Yang L, Wen JY, Wu KJ, Chen GQ, Li ZY, Ling JW, Huang BB, Xie YY, Dong YY, Fang YY, Wei DM, Chen G, Shi L, Huang WJ.   +14 more
europepmc   +1 more source

Mixed lineage kinase 3 mediates SARS‐CoV‐2‐induced kidney injury via the Hsp70‐IL‐17A axis

Interdisciplinary Medicine, EarlyView.
Kidney samples from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) showed upregulated expression and activity of Mixed Lineage Kinase (MLK3). Based on the mechanistic studies, we identified MLK3 as a critical player in promoting SARS‐CoV‐2‐induced kidney injury.
Sandeep Kumar, Sunil Kumar Singh, Piush Srivastava, Sowdhamini Mahendiran, Rakesh Sathish Nair, Harsh Vyas, Saket Jha, Niraj Nag, Navin Viswakarma, Hitesh Kapoor, Swathi Suresh, Periannan Sethupathi, Sang‐Ging Ong, Jerrold S. Levine, Suman Setty, Mathayan Manikannan, Bellur S. Prabhakar, Basabi Rana, Ajay Rana   +18 more
wiley   +1 more source

Activation of Angiotensin-Converting Enzyme 2 Mitigates Gastrointestinal Acute Radiation Syndrome. [PDF]

Int J Radiat Oncol Biol Phys
Sharma GP, Nissen A, Gasperetti T, Foeckler J, Frei AC, Kuehn R, Gerhartz M, Heinzelman P, Romero PA, Zenga J, Himburg HA.   +10 more
europepmc   +1 more source

The Effects of Angiotensin Receptor Neprilysin Inhibitor on Endoplasmic Reticulum Stress in Doxorubicin‐Mediated Cardiomyopathy‐Associated Heart Failure Model in Rats

Journal of Applied Toxicology, EarlyView.
ABSTRACT One of the most serious complications associated with the use of the chemotherapeutic agent doxorubicin (DOX) is cardiomyopathy. Although cardioprotective drugs such as angiotensin receptor‐neprilysin inhibitors (ARNI) are used to prevent cardiomyopathy in DOX patients, no studies have reported the relationship between ARNI and endoplasmic ...
Mert Unvan, Meryem İlkay Karagül, Hatice Oruç Demirbağ, Ebru Balli   +3 more
wiley   +1 more source