Results 141 to 150 of about 655,327 (339)

Intravenous lanadelumab for the treatment of moderately ill COVID‐19 patients

British Journal of Clinical Pharmacology, EarlyView.
Aims Kallikrein‐kinin system (KKS) dysregulation is hypothesized to play a pathogenetic role in COVID‐19‐associated pulmonary oedema. To investigate the efficacy and safety of intravenous lanadelumab, a monoclonal antibody that inhibits plasma kallikrein, in COVID‐19, we conducted a phase 2, open‐label, randomized‐controlled, proof‐of‐concept ...
Job J. Engel, Christine van Linge, W. Joost Wiersinga, Ilse J. E. Kouijzer, Quirijn de Mast, Robert‐Jan Hassing, Danique J. H. Huijbens, Helen L. Leavis, Roger Schutgens, Coen Maas, Kit C. B. Roes, Frank L. van de Veerdonk, Roger Brüggemann   +12 more
wiley   +1 more source

Renin–angiotensin system inhibition in COVID-19 patients: Friend or foe?

Anatolian Journal of Cardiology, 2020
Bilgehan Karadağ
doaj   +1 more source

The combination of angiotensin receptor-neprilysin inhibitor and sodium-glucose cotransporter-2 inhibitors in heart failure with reduced ejection fraction patients comorbid with diabetes mellitus [PDF]

, 2020
Fu‐Chih Hsiao, Chun-Ji Lin, Po‐Cheng Chang, C.L Wang, Pao‐Hsien Chu   +4 more
openalex   +1 more source

Possible therapeutic repositioning of valproic acid: From epileptic seizures to acute kidney injury

British Journal of Clinical Pharmacology, EarlyView.
Valproic acid, an anticonvulsant, may be repositioned to prevent acute kidney injury due to ischemia followed by reperfusion. It preserves renal functions, electrolyte homeostasis and active sodium transport in kidney tubules, and blocks the onset of hypertension.
Danilo Alves‐Bezerra, Luiza B. Negreiros, Amaury Pereira‐Acácio, Isadora G. Almeida, João P. M. Veloso‐Santos, Jarlene A. Lopes, Glória Costa‐Sarmento, Humberto Muzi‐Filho, Adalberto Vieyra   +8 more
wiley   +1 more source

Retarding the progression of chronic kidney disease with renin angiotensin system blockade

, 2012
RA Annigeri, M Limesh, Mani Mk, PC Kowdle, BSubba Rao, Sowmya Balasubramanian, R. Seshadri   +6 more
openalex   +1 more source

Angiotensin-converting enzyme inhibitory activity of four Amadori compounds (ACs) and mechanism analysis of N-(1-Deoxy-D-fructos-1-yl)-glycine (Fru-Gly)

, 2022
Renjie Zhou, Cheng Yang, Ting Xie, Jian Zhang, Chenqiang Wang, Ziqiang Ma, Lianfu Zhang   +6 more
openalex   +1 more source

Clinical Images: Sarcoidosis revealed by recurrent dactylitis

Arthritis &Rheumatology, EarlyView.
Thomas Subervie, Thibault Willaume, Amin Maazouzi, Jacques‐Eric Gottenberg, Jean Sibilia, Noëlle Weingertner, Eden Sebbag, Marc Scherlinger   +7 more
wiley   +1 more source

The Prevalence and Implications of Polypharmacy in Individuals With Type 1 Diabetes

Clinical Pharmacology &Therapeutics, EarlyView.
Polypharmacy is increasingly recognized as a relevant issue in diabetes care, but its prevalence and clinical relevance in individuals with type 1 diabetes remain underexplored. This study aimed to determine the prevalence of polypharmacy and to identify associated clinical and psychological factors. Participants were recruited from a tertiary diabetes
Namam Ali, Stephan van Erp, Cornelis Kramers, Cornelis J. Tack, Bastiaan E. de Galan   +4 more
wiley   +1 more source

The Renin–Angiotensin System Modulates SARS-CoV-2 Entry via ACE2 Receptor

Viruses
The renin–angiotensin system (RAS) plays a central role in cardiovascular regulation and has gained prominence in the pathogenesis of Coronavirus Disease 2019 (COVID-19) due to the critical function of angiotensin-converting enzyme 2 (ACE2) as the entry ...
Sophia Gagliardi, Tristan Hotchkin, Hasset Tibebe, Grace Hillmer, Dacia Marquez, Coco Izumi, Jason Chang, Alexander Diggs, Jiro Ezaki, Yuichiro J. Suzuki, Taisuke Izumi   +10 more
doaj   +1 more source

Resistant hypertension and renal denervation: Who's kidding whom? [PDF]

, 2014
Sever, P
core   +1 more source