Results 51 to 60 of about 636,232 (298)

What’s new in the renin-angiotensin system?

Cellular and Molecular Life Sciences (CMLS), 2004
.Cellular entry of enveloped viruses is often dependent on attachment proteins expressed on the host cell surface. Viral envelope proteins bind these receptors, and, in an incompletely understood process, facilitate fusion of the cellular and viral ...
J. Kuhn, Wei Li, H. Choe, M. Farzan
semanticscholar   +1 more source

Coronavirus Disease 2019 (COVID‐19) and Cardiovascular Disease: A Viewpoint on the Potential Influence of Angiotensin‐Converting Enzyme Inhibitors/Angiotensin Receptor Blockers on Onset and Severity of Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2020
recent study confirmed that respiratory syndrome uses severe acute respiratory syndrome coronavirus (SARS- CoV) angiotensin- converting enzyme 2 (ACE2) for ...
Junyi Guo, Zheng Huang, Li Lin, Jia-Gao Lv   +3 more
semanticscholar   +1 more source

Defective Renal Angiotensin III and AT2 Receptor Signaling in Prehypertensive Spontaneously Hypertensive Rats

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Previous studies demonstrated that angiotensin (Ang) III, not Ang II, is the predominant endogenous agonist for Ang type‐2 receptor (AT2R)‐induced natriuresis in normal rats, and that hypertensive 12‐week‐old spontaneously hypertensive rats ...
Brandon A. Kemp, Nancy L. Howell, Susanna R. Keller, John J. Gildea, Weijian Shao, Luis Gabriel Navar, Robert M. Carey   +6 more
doaj   +1 more source

Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin–angiotensin–aldosterone inhibitors

European Heart Journal, 2020
Aims The current pandemic coronavirus SARS-CoV-2 infects a wide age group but predominantly elderly individuals, especially men and those with cardiovascular disease. Recent reports suggest an association with use of renin–angiotensin–aldosterone system (
I. Sama, A. Ravera, B. Santema, H. van Goor, J. T. ter Maaten, J. Cleland, M. Rienstra, A. Friedrich, N. Samani, L. Ng, K. Dickstein, C. Lang, G. Filippatos, S. Anker, P. Ponikowski, M. Metra, D. V. van Veldhuisen, A. Voors   +17 more
semanticscholar   +1 more source

Protein-protein interactions of human somatic angiotensin-converting enzyme [PDF]

, 2011
In this study, novel disulphide bridges were engineered into the linker region of ACE [Angiotensin-converting enzyme] in an attempt to limit inter-domain movement, thereby producing a candidate for crystallisation and to determine the effect of these ...
Gordon, Kerry
core   +1 more source

Electronic sculpting of ligand-GPCR subtype selectivity:the case of angiotensin II [PDF]

, 2014
GPCR subtypes possess distinct functional and pharmacological profiles, and thus development of subtype-selective ligands has immense therapeutic potential.
Pappas, Charalampos G., Francesca Magnani, Jones, Emma S., Gerothanassis, Ioannis P., Emma S. Jones, Andreas G. Tzakos, Widdop, Robert E., Crook, Tim, Ishiguro, Susumu, Charalampos G. Pappas, Vassiliki Magafa, Tzakos, Andreas G., Naomi Ohta (735090), Jana Selent, Paul Cordopatis, Susumu Ishiguro, Ioannis P. Gerothanassis, Ohta, Naomi, Andreas G. Tzakos (1327620), Tim Crook, Naomi Ohta, Francesca Magnani (1327608), Ioannis P. Gerothanassis (1327626), Masaaki Tamura, Paul Cordopatis (1327614), Cordopatis, Paul, Sanja Bosnyak, Jana Selent (147923), Emma S. Jones (1327623), Robert E. Widdop (585063), Selent, Jana, Bosnyak, Sanja, Magnani, Francesca, Robert E. Widdop, Charalampos G. Pappas (1327617), Susumu Ishiguro (735091), Vassiliki Magafa (1327629), Sanja Bosnyak (1327611), Tamura, Masaaki, Masaaki Tamura (735096), Magafa, Vassiliki, Tim Crook (1069)   +41 more
core   +1 more source

NADPH-Oxidase, Rho-Kinase and Autophagy Mediate the (Pro)renin-Induced Pro-Inflammatory Microglial Response and Enhancement of Dopaminergic Neuron Death

Antioxidants, 2021
Dysregulation of the tissue renin–angiotensin system (RAS) is involved in tissue oxidative and inflammatory responses. Among RAS components, renin, its precursor (pro)renin and its specific receptor (PRR) have been less investigated, particularly in the ...
Andrea Lopez-Lopez, Begoña Villar-Cheda, Aloia Quijano, Pablo Garrido-Gil, María Garcia-Garrote, Carmen Díaz-Ruiz, Ana Muñoz, José L. Labandeira-Garcia   +7 more
doaj   +1 more source

Perinatal changes in estradiol and Ang II concentrations in pregnant women with pulmonary arterial hypertension and their correlation

Hypertension in Pregnancy, 2019
Objective: This study aimed to analyze the perinatal changes of plasma estradiol (E2) and angiotensin II (Ang II) in pregnant women with pulmonary arterial hypertension before and after cesarean section. Methods: Depending on pulmonary arterial pressure,
Yanshuang Wang, Hao Che, Kai Kang, Guosheng Zhao, Xiaoguang Li, Xiangming Che, Mingjun Xu, Liyun Zhao   +7 more
doaj   +1 more source

Angiotensinergic Neurotransmissions in the Medial Amygdala Nucleus Modulate Behavioral Changes in the Forced Swimming Test Evoked by Acute Restraint Stress in Rats

Cells, 2021
We investigated the role of angiotensin II type 1 (AT1 receptor) and type 2 (AT2 receptor) and MAS receptors present in the medial amygdaloid nucleus (MeA) in behavioral changes in the forced swimming test (FST) evoked by acute restraint stress in male ...
Camila Marchi-Coelho, Willian Costa-Ferreira, Lilian L. Reis-Silva, Carlos C. Crestani   +3 more
doaj   +1 more source

The diagnostic value of angiotensin, g-GT, blood lactate, and renal resistance index combined detection in acute kidney injury after neonatal asphyxia [PDF]

Journal of Medical Biochemistry
Background: To investigate the diagnostic value of angiotensin (Ang), gamma-glutamyltransferase (g-GT), blood lactic acid and renal resistive index (RRI) for acute kidney injury (AKI) after neonatal asphyxia.
Shi Xiaoqing, Dai Liying, Wang Ying, Deng Fang   +3 more
doaj   +1 more source