Results 31 to 40 of about 636,232 (298)

Angiotensin-neprilysin inhibition versus enalapril in heart failure.

New England Journal of Medicine, 2014
BACKGROUND We compared the angiotensin receptor-neprilysin inhibitor LCZ696 with enalapril in patients who had heart failure with a reduced ejection fraction. In previous studies, enalapril improved survival in such patients.
J. McMurray, M. Packer, Akshay S. Desai, J. Gong, M. Lefkowitz, A. Rizkala, J. Rouleau, Victor C. Shi, S. Solomon, K. Swedberg, M. Zile   +10 more
semanticscholar   +1 more source

Association of Inpatient Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers With Mortality Among Patients With Hypertension Hospitalized With COVID-19

Circulation Research, 2020
Supplemental Digital Content is available in the text. Rationale: Use of ACEIs (angiotensin-converting enzyme inhibitors) and ARBs (angiotensin II receptor blockers) is a major concern for clinicians treating coronavirus disease 2019 (COVID-19) in ...
Peng Zhang, Lihua Zhu, Jingjing Cai, Fang Lei, Juan-Juan Qin, Jing Xie, Ye Liu, Yanci Zhao, Xue-Wei Huang, Li-Jin Lin, Meng Xia, Ming-Ming Chen, Xu Cheng, Xiao Zhang, D. Guo, Yuanyuan Peng, Yan-Xiao Ji, Jing Chen, Zhi-Gang She, Yibin Wang, Qingbo Xu, Ren-Fu Tan, Hai-tao Wang, Jun Lin, Pengcheng Luo, Shou-Zhi Fu, Hong-Bing Cai, P. Ye, B. Xiao, Wei-Ming Mao, Li-Ming Liu, You-qin Yan, Mingyu Liu, Man-Hua Chen, Xiao-Jing Zhang, Xinghuan Wang, R. Touyz, J. Xia, Bing-Hong Zhang, Xiao-Dong Huang, Yufeng Yuan, R. Loomba, Peter P. Liu, Hongliang Li   +43 more
semanticscholar   +1 more source

Renin–Angiotensin–Aldosterone System Inhibitors and Risk of Covid-19

New England Journal of Medicine, 2020
Background There is concern about the potential of an increased risk related to medications that act on the renin–angiotensin–aldosterone system in patients exposed to coronavirus disease 2019 (Covid-19), because the viral receptor is angiotensin ...
H. Reynolds, S. Adhikari, C. Pulgarin, A. Troxel, Eduardo Iturrate, Stephen B. Johnson, A. Hausvater, J. Newman, J. Berger, S. Bangalore, S. Katz, G. Fishman, Dennis Kunichoff, Yu Chen, G. Ogedegbe, J. Hochman   +15 more
semanticscholar   +1 more source

Adenoviral delivery of angiotensin-(1-7) or angiotensin-(1-9) inhibits cardiomyocyte hypertrophy via the mas or angiotensin Type 2 receptor [PDF]

, 2012
The counter-regulatory axis of the renin angiotensin system peptide angiotensin-(1-7) [Ang-(1-7)] has been identified as a potential therapeutic target in cardiac remodelling, acting via the mas receptor.
Nicklin Stuart A., Almalik Abdulaziz, Bruno M D C Godinho, Flores-Muñoz Monica, Flores-Muñoz, M., Almalik, A., Nicklin, S.A., Monica Flores-Muñoz, Stuart A Nicklin, Abdulaziz Almalik, Godinho, B.M.D.C., Godinho Bruno M. D. C.   +11 more
core   +2 more sources

A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury

Nature Medicine, 2005
During several months of 2003, a newly identified illness termed severe acute respiratory syndrome (SARS) spread rapidly through the world. A new coronavirus (SARS-CoV) was identified as the SARS pathogen, which triggered severe pneumonia and acute ...
K. Kuba, Y. Imai, Shuan Rao, Hong Gao, F. Guo, Bin Guan, Yi Huan, Peng-Fei Yang, Yan-Li Zhang, Wei Deng, L. Bao, Binlin Zhang, Guang Liu, Z. Wang, M. Chappell, Yanxin Liu, D. Zheng, A. Leibbrandt, T. Wada, Arthur S Slutsky, De-Pei Liu, C. Qin, Cheng-Yu Jiang, J. Penninger   +23 more
semanticscholar   +1 more source

Signaling of angiotensin II-induced vascular protein synthesis in conduit and resistance arteries in vivo [PDF]

, 2004
<b>Background</b> From in vitro studies, it has become clear that several signaling cascades are involved in angiotensin II-induced cellular hypertrophy.
Martens Fabrice MAC, Fabrice MAC Martens, Touyz, R.M., Daigle, Christine, Martens, Fabrice, Touyz Rhian M, Dao Huy, Christine Daigle, Huy Hao Dao, Daphné Girardot, Rhian M Touyz, Moreau Pierre, Girardot, D., Daigle, C., Dao, H., Moreau, P., Girardot, Daphné, Martens, F.M.A.C., Dao, Huy, Daigle Christine, Moreau, Pierre, Girardot Daphné, Pierre Moreau, Touyz, Rhian   +23 more
core   +2 more sources

Manipulation of components of the renin angiotensin system in renal proximal tubules fails to alter atherosclerosis in hypercholesterolemic mice

Frontiers in Cardiovascular Medicine, 2023
Background and objectiveWhole body manipulation of the renin-angiotensin system (RAS) consistently exerts profound effects on experimental atherosclerosis development. A deficit in the literature has been a lack of attention to the effects of sex.
Masayoshi Kukida, Naofumi Amioka, Dien Ye, Hui Chen, Jessica J. Moorleghen, Ching-Ling Liang, Deborah A. Howatt, Yuriko Katsumata, Yuriko Katsumata, Motoko Yanagita, Motoko Yanagita, Hisashi Sawada, Hisashi Sawada, Hisashi Sawada, Alan Daugherty, Alan Daugherty, Alan Daugherty, Hong S. Lu, Hong S. Lu, Hong S. Lu   +19 more
doaj   +1 more source

Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus

Nature, 2003
Spike (S) proteins of coronaviruses, including the coronavirus that causes severe acute respiratory syndrome (SARS), associate with cellular receptors to mediate infection of their target cells. Here we identify a metallopeptidase, angiotensin-converting
Wenhui Li, M. Moore, N. Vasilieva, J. Sui, S. Wong, M. Berne, M. Somasundaran, J. Sullivan, K. Luzuriaga, T. Greenough, H. Choe, M. Farzan   +11 more
semanticscholar   +1 more source

COVID-19 and Acute Kidney Injury ― Direct and Indirect Pathophysiological Mechanisms Underlying Lesion Development

Anais da Academia Brasileira de Ciências, 2022
COVID-19 is a pandemic disease caused by the SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) responsible for millions of deaths worldwide.
ANTÔNIO V.B. DA SILVA, JOÃO DE A.G. CAMPANATI, ISADORA DE S. BARCELOS, ALBERTO C.L. SANTOS, UILDSON P. DE DEUS, TELMA DE J. SOARES, LILIANY S. DE B. AMARAL   +6 more
doaj   +1 more source

Angiotensin-Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction.

New England Journal of Medicine, 2019
BACKGROUND The angiotensin receptor-neprilysin inhibitor sacubitril-valsartan led to a reduced risk of hospitalization for heart failure or death from cardiovascular causes among patients with heart failure and reduced ejection fraction.
S. Solomon, J. McMurray, I. Anand, J. Ge, C. Lam, A. Maggioni, F. Martinez, M. Packer, M. Pfeffer, B. Pieske, M. Redfield, J. Rouleau, D. V. van Veldhuisen, F. Zannad, M. Zile, Akshay S. Desai, Brian C. Claggett, P. Jhund, S. Boytsov, J. Comín-Colet, J. Cleland, H. Düngen, E. Goncalvesova, T. Katova, Jose F. Kerr Saraiva, M. Lelonek, B. Merkely, M. Senni, Sanjiv J. Shah, Jing-Min Zhou, A. Rizkala, J. Gong, Victor C. Shi, M. Lefkowitz   +33 more
semanticscholar   +1 more source