Results 11 to 20 of about 636,232 (298)

Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System

open access: yesCirculation Research, 2020
ACE2 (angiotensin-converting enzyme 2) has a multiplicity of physiological roles that revolve around its trivalent function: a negative regulator of the renin-angiotensin system, facilitator of amino acid transport, and the severe acute respiratory ...
Anthony J Turner   +2 more
exaly   +2 more sources

Role of the ACE2/Angiotensin 1–7 Axis of the Renin–Angiotensin System in Heart Failure

open access: yesCirculation Research, 2016
Heart failure remains the most common cause of death and disability, and a major economic burden, in industrialized nations. Physiological, pharmacological, and clinical studies have demonstrated that activation of the renin-angiotensin system is a key ...
Vaibhav Patel, Jiuchang Zhong
exaly   +2 more sources

Renin Angiotensin System (RAS) Pathways in COVID Pathogenesis

open access: yesNational Board of Examinations Journal of Medical Sciences, 2023
Background – Covid-19 pandemic has posed some rare diagnostic & therapeutic challenges. Recurrent waves of varying severity are caused by ongoing mutations in the virus. It is vital to understand the fundamentals of Renin Angiotensin System (RAS) pathway
Sampreeti Mukherjee, Minu Bajpai
doaj   +1 more source

The angiotensin-converting enzyme (ACE) gene family of Anopheles gambiae. [PDF]

open access: yes, 2005
Background Members of the M2 family of peptidases, related to mammalian angiotensin converting enzyme (ACE), play important roles in regulating a number of physiological processes.
Isaac, R. Elwyn   +4 more
core   +6 more sources

Effects of Vasodepressor vs. Vasopressor Arms of Renin Angiotensin System on Renal Hemodynamic Regulation in Renal Ischemia-Reperfusion Injury; Sex Difference [PDF]

open access: yesمجله دانشکده پزشکی اصفهان, 2022
The exact mechanisms involved in acute renal injury (AKI) due to renal ischemia-reperfusion (IR) are not fully understood, although it has been shown that the renin-angiotensin system (RAS) may play an important role in IR-associated AKI.
Farzaneh Karimi   +4 more
doaj   +1 more source

Exploiting Knowledge on Structure–Activity Relationships for Designing Peptidomimetics of Endogenous Peptides

open access: yesBiomedicines, 2021
Endogenous peptides are important mediators in cell communication, being consequently involved in many physiological processes. Their use as therapeutic agents is limited due to their poor pharmacokinetic profile. To circumvent this drawback, alternative
Juan J. Perez
doaj   +1 more source

The vascular renin-angiotensin-aldosterone system [PDF]

open access: yes, 2001
PhDThe renin-angiotensin-aldosterone system (RAAS) is one of the major regulators of blood pressure. The actions and generation of RAAS components at the tissue level are less well appreciated.
Xiao, Fang
core   +4 more sources

Human mesenchymal stromal cells do not express ACE2 and TMPRSS2 and are not permissive to SARS‐CoV‐2 infection

open access: yesStem Cells Translational Medicine, 2021
Anti‐inflammatory and immune‐modulatory therapies have been proposed for the treatment of COVID‐19 and its most serious complications. Among others, the use of mesenchymal stromal cells (MSCs) is under investigation given their well‐documented anti ...
Maria A. Avanzini   +13 more
doaj   +1 more source

Angiotensin peptides in the regulation of adrenal cortical function

open access: yesExploration of Medicine, 2021
The adrenal cortex plays a key role in the regulation of metabolism, salt and water homeostasis and sex differentiation by synthesizing glucocorticoid, mineralocorticoid and androgen hormones.
Gian Paolo Rossi   +4 more
doaj   +1 more source

Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target

open access: yesIntensive Care Medicine, 2020
A novel infectious disease, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was detected in Wuhan, China, in December 2019. The disease (COVID-19) spread rapidly, reaching epidemic proportions in China, and has been found in 27 ...
Haibo Zhang   +4 more
semanticscholar   +1 more source

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