Results 11 to 20 of about 313,972 (268)

Preparation, Radiolabeling with ⁶⁸Ga/¹⁷⁷Lu and Preclinical Evaluation of Novel Angiotensin Peptide Analog: A New Class of Peptides for Breast Cancer Targeting

Pharmaceuticals, 2023
Aim: Angiotensin II (AngII) is known to play a significant part in the development of breast cancer by triggering cell propagation of breast cancer, tumor angiogenesis, and regulating tumor invasion and cell migration. AngII arbitrates its action via two
Subhani M. Okarvi
doaj   +1 more source

How does angiotensin AT2 receptor activation help neuronal differentiation and improve neuronal pathological situations?

Frontiers in Endocrinology, 2012
The AT2 receptor of angiotensin II (Ang II) has long been thought to be limited to few tissues, with the primary effect of counteracting the AT1 receptor. Functional studies in neuronal cells have demonstrated AT2 receptor capability to modulate neuronal
Marie-Odile eGuimond, Nicole eGallo-Payet   +1 more
doaj   +1 more source

Manipulation of components of the renin angiotensin system in renal proximal tubules fails to alter atherosclerosis in hypercholesterolemic mice

Frontiers in Cardiovascular Medicine, 2023
Background and objectiveWhole body manipulation of the renin-angiotensin system (RAS) consistently exerts profound effects on experimental atherosclerosis development. A deficit in the literature has been a lack of attention to the effects of sex.
Masayoshi Kukida, Naofumi Amioka, Dien Ye, Hui Chen, Jessica J. Moorleghen, Ching-Ling Liang, Deborah A. Howatt, Yuriko Katsumata, Yuriko Katsumata, Motoko Yanagita, Motoko Yanagita, Hisashi Sawada, Hisashi Sawada, Hisashi Sawada, Alan Daugherty, Alan Daugherty, Alan Daugherty, Hong S. Lu, Hong S. Lu, Hong S. Lu   +19 more
doaj   +1 more source

COVID-19 and Acute Kidney Injury ― Direct and Indirect Pathophysiological Mechanisms Underlying Lesion Development

Anais da Academia Brasileira de Ciências, 2022
COVID-19 is a pandemic disease caused by the SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) responsible for millions of deaths worldwide.
ANTÔNIO V.B. DA SILVA, JOÃO DE A.G. CAMPANATI, ISADORA DE S. BARCELOS, ALBERTO C.L. SANTOS, UILDSON P. DE DEUS, TELMA DE J. SOARES, LILIANY S. DE B. AMARAL   +6 more
doaj   +1 more source

Role of Melatonin in Angiotensin and Aging

Molecules, 2021
The cellular utilization of oxygen leads to the generation of free radicals in organisms. The accumulation of these free radicals contributes significantly to aging and several age-related diseases.
Ahmet Ozer Sehirli, Serkan Sayıner, Ugochukwu Chukwunyere, Nedime Serakinci   +3 more
doaj   +1 more source

The Origin and Advancement of Cardiovascular Physiology in Brazil: The contribution of Eduardo Krieger to research groups

Frontiers in Physiology, 2016
Since 1996, symposia devoted to the discussion of advances in cardiovascular physiology have been alternately organized by Brazilian research groups, most of which were created or joined by PhD trainees of Eduardo M Krieger.
Elisardo C Vasquez, Elisardo C Vasquez
doaj   +1 more source

Effect of Increased Potassium Intake on Adrenal Cortical and Cardiovascular Responses to Angiotensin II: A Randomized Crossover Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Increased potassium intake lowers blood pressure in patients with hypertension, but increased potassium intake also elevates plasma concentrations of the blood pressure‐raising hormone aldosterone.
Rasmus Dreier, Ulrik B. Andersen, Julie L. Forman, Majid Sheykhzade, Martin Egfjord, Jørgen L. Jeppesen   +5 more
doaj   +1 more source

Defective Renal Angiotensin III and AT2 Receptor Signaling in Prehypertensive Spontaneously Hypertensive Rats

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Previous studies demonstrated that angiotensin (Ang) III, not Ang II, is the predominant endogenous agonist for Ang type‐2 receptor (AT2R)‐induced natriuresis in normal rats, and that hypertensive 12‐week‐old spontaneously hypertensive rats ...
Brandon A. Kemp, Nancy L. Howell, Susanna R. Keller, John J. Gildea, Weijian Shao, Luis Gabriel Navar, Robert M. Carey   +6 more
doaj   +1 more source

NADPH-Oxidase, Rho-Kinase and Autophagy Mediate the (Pro)renin-Induced Pro-Inflammatory Microglial Response and Enhancement of Dopaminergic Neuron Death

Antioxidants, 2021
Dysregulation of the tissue renin–angiotensin system (RAS) is involved in tissue oxidative and inflammatory responses. Among RAS components, renin, its precursor (pro)renin and its specific receptor (PRR) have been less investigated, particularly in the ...
Andrea Lopez-Lopez, Begoña Villar-Cheda, Aloia Quijano, Pablo Garrido-Gil, María Garcia-Garrote, Carmen Díaz-Ruiz, Ana Muñoz, José L. Labandeira-Garcia   +7 more
doaj   +1 more source

Angiotensinergic Neurotransmissions in the Medial Amygdala Nucleus Modulate Behavioral Changes in the Forced Swimming Test Evoked by Acute Restraint Stress in Rats

Cells, 2021
We investigated the role of angiotensin II type 1 (AT1 receptor) and type 2 (AT2 receptor) and MAS receptors present in the medial amygdaloid nucleus (MeA) in behavioral changes in the forced swimming test (FST) evoked by acute restraint stress in male ...
Camila Marchi-Coelho, Willian Costa-Ferreira, Lilian L. Reis-Silva, Carlos C. Crestani   +3 more
doaj   +1 more source