Periodontopathogens degrade angiotensin I from the human renin–angiotensin system through surface-attached proteases [PDF]
Scientific ReportsThe renin–angiotensin system (RAS) has its effects through biologically-active peptides, the angiotensins (Ang). The angiotensinogen-derived precursor, Ang I, is cleaved either to proinflammatory Ang II, which increases blood pressure or to Ang 1–7 ...
Irena Waligórska +12 more
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Angiotensin II/Angiotensin I Ratio as a New Pharmacodynamic Parameter for Population Modelling in Healthy Adults and Children with Heart Failure Treated with Enalapril [PDF]
PharmaceuticsBackground/Objectives: Since 2023, enalapril orodispersible minitablets have been approved in Europe for paediatric heart failure from birth, but no population pharmacodynamic analyses have yet been conducted in this patient group. The objectives were to
Melina Steichert +5 more
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Angiotensin converting enzyme 2 (ACE2) - the major receptor for SARS-CoV-2 virus [PDF]
Farmacja Polska, 2021 The renin-angiotensin-aldosterone system (RAS) plays a significant role in the regulation of the water and electrolyte balance. Renin from the kidneys converts angiotensinogen to angiotensin I. Angiotensin converting enzyme (ACE) catalyzes the conversion
Sonia Frankowska +3 more
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Jurnal Penyakit Dalam Indonesia, 2021 Introduction. The presence of ACE gene polymorphism is expected to have a role in cardiovascular diseases, including coronary slow flow phenomenon (CSFP).
Arlis Karlina +8 more
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Des-Aspartate-Angiotensin I Attenuates Mortality of Mice Exposed to Gamma Radiation via a Novel Mechanism of Action. [PDF]
PLoS ONE, 2015 ACE inhibitors and ARBs (angiotensin receptor blockers) have been shown to attenuate radiation injuries in animal models of lethal gamma irradiation. These two classes of drug act by curtailing the actions of angiotensin II-linked inflammatory pathways ...
Hong Wang +3 more
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Candesartan Normalizes Changes in Retinal Blood Flow and p22phox in the Diabetic Rat Retina
Pathophysiology, 2021 Angiotensin II has been implicated in the progression of diabetic retinopathy, which is characterized by altered microvasculature, oxidative stress, and neuronal dysfunction.
Randa S. Eshaq +6 more
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Animals, 2023 Background: Chronic renin–angiotensin–aldosterone system (RAAS) activation is harmful. Amlodipine activates RAAS in humans and dogs, but contradictory data exist for systemically hypertensive (SHT) cats.
Darcy Adin +5 more
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Pocket ACEs: Discovering new function within an old player
Frontiers in Physiology, 2023 Angiotensin-converting enzyme (ACE) is canonically known for its role in the renin-angiotensin system (RAS) where its conversion of angiotensin I (Ang I) to the bioactive peptide angiotensin II (Ang II) helps to regulate blood pressure, electrolyte, and ...
Matthew Leong, Xiaomo Li, Manita Chaum
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Frontiers in Pharmacology, 2020 BackgroundThe importance of dietary potassium in health and disease has been underestimated compared with that placed on dietary sodium. Larger effort has been made on reduction of sodium intake and less on the adequate dietary potassium intake, although
Carlos P. Vio +7 more
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Olmesartan potentiates the anti-angiogenic effect of sorafenib in mice bearing Ehrlich's ascites carcinoma: role of angiotensin (1-7). [PDF]
PLoS ONE, 2014 Local renin-angiotensin systems exist in various malignant tumor tissues; this suggests that the main effector peptide, angiotensin II, could act as a key factor in tumor growth.
Mohammad M Abd-Alhaseeb +3 more
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