Results 41 to 50 of about 221,266 (311)

ACE2 of the heart: From angiotensin I to angiotensin (1–7) [PDF]

Cardiovascular Research, 2007
Angiotensin II (Ang II), a bioactive peptide of the renin-angiotensin system (RAAS), plays an important role in the development of cardiovascular diseases (CVD). Pharmacological inhibition of angiotensin-converting enzyme (ACE), the Ang II forming enzyme, or specific blockade of Ang II binding to angiotensin type 1 receptor (AT1R) through which it ...
Shlomo, Keidar, Marielle, Kaplan, Aviva, Gamliel-Lazarovich   +2 more
openaire   +2 more sources

Electronic sculpting of ligand-GPCR subtype selectivity:the case of angiotensin II [PDF]

, 2014
GPCR subtypes possess distinct functional and pharmacological profiles, and thus development of subtype-selective ligands has immense therapeutic potential.
Pappas, Charalampos G., Francesca Magnani, Jones, Emma S., Gerothanassis, Ioannis P., Emma S. Jones, Andreas G. Tzakos, Widdop, Robert E., Crook, Tim, Ishiguro, Susumu, Charalampos G. Pappas, Vassiliki Magafa, Tzakos, Andreas G., Naomi Ohta (735090), Jana Selent, Paul Cordopatis, Susumu Ishiguro, Ioannis P. Gerothanassis, Ohta, Naomi, Andreas G. Tzakos (1327620), Tim Crook, Naomi Ohta, Francesca Magnani (1327608), Ioannis P. Gerothanassis (1327626), Masaaki Tamura, Paul Cordopatis (1327614), Cordopatis, Paul, Sanja Bosnyak, Jana Selent (147923), Emma S. Jones (1327623), Robert E. Widdop (585063), Selent, Jana, Bosnyak, Sanja, Magnani, Francesca, Robert E. Widdop, Charalampos G. Pappas (1327617), Susumu Ishiguro (735091), Vassiliki Magafa (1327629), Sanja Bosnyak (1327611), Tamura, Masaaki, Masaaki Tamura (735096), Magafa, Vassiliki, Tim Crook (1069)   +41 more
core   +1 more source

Effects of the selective chymase inhibitor TEI‐F00806 on the intrarenal renin–angiotensin system in salt‐treated angiotensin I‐infused hypertensive mice

Experimental Physiology, 2018
New Findings What is the central question of this study? Can chymase inhibition prevent angiotensin I‐induced hypertension through inhibiting the conversion of angiotensin I to angiotensin II in the kidney?
Tuba M. Ansary, Maki Urushihara, Yoshihide Fujisawa, Sayaka Nagata, Hidenori Urata, Daisuke Nakano, Hitomi Hirofumi, Kazuo Kitamura, Shoji Kagami, Akira Nishiyama   +9 more
doaj   +1 more source

Ethanolic Extract of Salvia hispanica L. Regulates Blood Pressure by Modulating the Expression of Genes Involved in BP-Regulatory Pathways

Molecules, 2020
Hypertension (HT) is considered to be a potential risk factor for cardiovascular diseases and has been directly related to pathologies such as obesity and dyslipidemias.
Gerardo I. Arredondo-Mendoza, Zacarías Jiménez-Salas, Francisco Javier Guzmán-de la Garza, Elizabeth Solís-Pérez, Manuel López-Cabanillas-Lomelí, Blanca Edelia González-Martínez, Eduardo Campos-Góngora   +6 more
doaj   +1 more source

Hypoxia-induced signaling in angiogenesis : role of mTOR, HIF and Angiotensin II [PDF]

, 2007
This thesis includes the work of four different projects I have been following during my time as a PhD student; (1) the characterization of mTOR-associated signaling and endothelial cell proliferation in response to hypoxia, and (2) identification of ...
Petrimpol, Marco Renato
core   +1 more source

Captopril Enhances Cardiac Vagal but Not Sympathetic Neurotransmission in Pithed Rats

Journal of Pharmacological Sciences, 2004
The effect of captopril on neurally evoked bradycardia and tachycardia was investigated in pithed rats. Captopril enhanced the vagal nerve stimulation-evoked bradycardia.
Yoshinobu Takata, Takanori Arai, Shigeto Suzuki, Junichi Kurihara, Takashi Uezono, Yoko Okubo, Hitoshi Kato   +6 more
doaj   +1 more source

Angiotensin II induces soluble fms-Like tyrosine kinase-1 release via calcineurin signaling pathway in pregnancy [PDF]

, 2007
Maternal endothelial dysfunction in preeclampsia is associated with increased soluble fms-like tyrosine kinase-1 (sFlt-1), a circulating antagonist of vascular endothelial growth factor and placental growth factor.
Kellems, Rodney E., Kellems, Rodney E, Mi, TieJuan, Xia, Yang, Sun, C, Hewett, Peter W, Abbasi, S, Zhou, CC, Mi, T, Abbasi, Shahrzad, Hewett, Peter, Xia, Y, Sun, ChunXiao, Kellems, RE, Ahmed, Asif, Hewett, Peter W., Xia, L, Ahmad, Shakil, Xia, Lingwei, Zhou, Cissy Chenyi   +19 more
core   +1 more source

Clinical Outcomes of Angiotensin II Therapy in Vasoplegic Shock: A Systematic Review and Meta-Analysis

Life
Background: Angiotensin II is a peptide hormone vasopressor that activates angiotensin type 1 (AT1) receptors leading to vasoconstriction, the augmentation of arterial blood pressure (ABP), and organ perfusion.
Ans Alamami, Alaa Rahhal, Bara Alqudah, Ahmed Shebani, Abdelkarim Alammora, Hashim Mohammad, Amr S. Omar, Ahmed Labib Shehatta   +7 more
doaj   +1 more source

Characterization of the intrarenal renin‐angiotensin system in cats with naturally occurring chronic kidney disease

Journal of Veterinary Internal Medicine, 2022
Background The role of the renin‐angiotensin‐aldosterone system in cats with chronic kidney disease (CKD) is incompletely understood. Objective To characterize components of the intrarenal renin‐angiotensin system (RAS) in cats with CKD.
Bianca N. Lourenço, Amanda E. Coleman, Roy D. Berghaus, Jaime L. Tarigo, Chad W. Schmiedt, Scott A. Brown   +5 more
doaj   +1 more source

Alterations in the Renin-Angiotensin System in Experimental Septic Shock

Critical Care Explorations
OBJECTIVES:. To analyze dynamic changes in the renin-angiotensin system (RAS) during septic shock, focusing on angiotensin-converting enzyme (ACE) activity and the balance between angiotensin peptides, using a mass spectrometry method.
Bruno Garcia, MD, PhD, Benoit Ter Schiphorst, MD, MSc, Fuhong Su, MD, PhD, Adrien Picod, MD, PhD, Theo Ikenna-Uba, PhD, Raphaël Favory, MD, PhD, Filippo Annoni, MD, Alexandre Mebazaa, MD, PhD, Jean-Louis Vincent, MD, PhD, Jacques Creteur, MD, PhD, Fabio S. Taccone, MD, PhD, Antoine Herpain, MD   +11 more
doaj   +1 more source