Results 11 to 20 of about 206,446 (295)

The systemic renin-angiotensin system in COVID-19

Scientific Reports, 2022
SARS-CoV-2 gains cell entry via angiotensin-converting enzyme (ACE) 2, a membrane-bound enzyme of the “alternative” (alt) renin-angiotensin system (RAS). ACE2 counteracts angiotensin II by converting it to potentially protective angiotensin 1–7.
Roman Reindl-Schwaighofer, Sebastian Hödlmoser, Oliver Domenig, Katharina Krenn, Farsad Eskandary, Simon Krenn, Christian Schörgenhofer, Benedikt Rumpf, Mario Karolyi, Marianna T. Traugott, Agnes Abrahamowicz, Viktoria Tinhof, Hannah Mayfurth, Vincent Rathkolb, Sebastian Mußnig, Lukas Schmölz, Roman Ullrich, Andreas Heinzel, Franz König, Christina Binder, Diana Bonderman, Robert Strassl, Elisabeth Puchhammer-Stöckl, Gregor Gorkiewicz, Judith H. Aberle, Bernd Jilma, Christoph Wenisch, Marko Poglitsch, Rainer Oberbauer, Alexander Zoufaly, Manfred Hecking   +30 more
doaj   +1 more source

Angiotensin-[1-12] interacts with angiotensin type I receptors [PDF]

Neuropharmacology, 2014
Angiotensin-(1-12) [Ang-(1-12)], a newer member of angiotensin peptides, is proposed to be converted enzymatically to angiotensin I (Ang I) and to angiotensin II (Ang II); the latter being the bioactive peptide. We studied the Ang-(1-12) and Ang II responses in COS-7 cells or CHO cells transfected with 5 μg AT1R by monitoring [Ca(2+)]i using the Fluo-4.
Chan, King Hang, Chen, Yi Hung, Zhang, Ying, Wong, Yung Hou, Dun, Nae J.   +4 more
openaire   +3 more sources

Renin angiotensin aldosterone system in anaphylactic reactions induced by immunotherapy

Allergology International, 1998
Although patients with a history of hymenoptera venom anaphylaxis showed significantly reduced plasma levels of angiotensin-I and angiotensin-II compared to controls, there is no study in the literature to investigate the renin angiotensin aldosterone ...
Mehmet Karaayvaz, Nejat Ozangüç
doaj   +1 more source

Tripeptide IRW Improves AMPK/eNOS Signaling Pathway via Activating ACE2 in the Aorta of High-Fat-Diet-Fed C57BL/6 Mice

Biology, 2023
This study aims to investigate the effect of tripeptide IRW on the local renin–angiotensin system (RAS), particularly angiotensin-converting enzyme 2 (ACE2), and their association with signaling pathways in the aorta of a high-fat-diet (HFD)-induced ...
Fatemeh Ashkar, Khushwant S. Bhullar, Xu Jiang, Jianping Wu   +3 more
doaj   +1 more source

Angiotensin-Converting Enzyme Inhibitor Does Not Suppress Renal Angiotensin II Levels in Angiotensin I–Infused Rats

Journal of Pharmacological Sciences, 2013
Angiotensin II (Ang II) infusion into rats elevates local angiotensin II levels through an AT1 receptor–dependent pathway in the kidney. We examined whether treatment with an angiotensin-converting enzyme (ACE) inhibitor, temocapril, or an AT1-receptor ...
Keisuke Ohnishi, Miki Murase, Daisuke Nakano, Nicolas Pelisch, Hirofumi Hitomi, Hiroyuki Kobori, Satoshi Morimoto, Hirohito Mori, Tsutomu Masaki, Koji Ohmori, Masakazu Kohno, Atsuhiro Ichihara, Akira Nishiyama   +12 more
doaj   +1 more source

Angiotensin I and angiotensin II concentrations and their ratio in catecholamine-resistant vasodilatory shock

Critical Care, 2020
Background In patients with vasodilatory shock, plasma concentrations of angiotensin I (ANG I) and II (ANG II) and their ratio may reflect differences in the response to severe vasodilation, provide novel insights into its biology, and predict clinical ...
Rinaldo Bellomo, Richard G. Wunderink, Harold Szerlip, Shane W. English, Laurence W. Busse, Adam M. Deane, Ashish K. Khanna, Michael T. McCurdy, Marlies Ostermann, Paul J. Young, Damian R. Handisides, Lakhmir S. Chawla, George F. Tidmarsh, Timothy E. Albertson   +13 more
doaj   +1 more source

Angiotensin II receptor I auto-antibodies following SARS-CoV-2 infection.

PLoS ONE, 2021
BackgroundCoronavirus disease 2019 (COVID-19) is associated with endothelial activation and coagulopathy, which may be related to pre-existing or infection-induced pro-thrombotic autoantibodies such as those targeting angiotensin II type I receptor (AT1R-
Yonghou Jiang, Fergal Duffy, Jennifer Hadlock, Andrew Raappana, Sheila Styrchak, Ingrid Beck, Fred D Mast, Leslie R Miller, William Chour, John Houck, Blair Armistead, Venkata R Duvvuri, Winnie Yeung, Micaela Haglund, Jackson Wallner, Julie A Wallick, Samantha Hardy, Alyssa Oldroyd, Daisy Ko, Ana Gervassi, Kim M Murray, Henry Kaplan, John D Aitchison, James R Heath, D Noah Sather, Jason D Goldman, Lisa Frenkel, Whitney E Harrington   +27 more
doaj   +2 more sources

IRW (Isoleucine–Arginine–Tryptophan) Improves Glucose Tolerance in High Fat Diet Fed C57BL/6 Mice via Activation of Insulin Signaling and AMPK Pathways in Skeletal Muscle

Biomedicines, 2022
IRW (Isoleucine–Arginine–Tryptophan), has antihypertensive and anti-inflammatory properties in cells and animal models and prevents angiotensin-II- and tumor necrosis factor (TNF)-α-induced insulin resistance (IR) in vitro. We investigated the effects of
Stepheny C. de Campos Zani, Myoungjin Son, Khushwant S. Bhullar, Catherine B. Chan, Jianping Wu   +4 more
doaj   +1 more source

Renin-angiotensin-aldosterone system inhibitors – a realm of confusion in COVID-19

Journal of Ideas in Health, 2021
Currently, there is a persisting dispute regarding the renin-angiotensin-aldosterone-system (RAAS) inhibitors' safety of use in COVID-19 pandemics. On one side, RAAS inhibitors appear to determine an overexpression of ACE2, the receptor of SARS-CoV-2 ...
Angela Madalina Lazar
doaj   +1 more source

Characterization of the intrarenal renin‐angiotensin system in cats with naturally occurring chronic kidney disease

Journal of Veterinary Internal Medicine, 2022
Background The role of the renin‐angiotensin‐aldosterone system in cats with chronic kidney disease (CKD) is incompletely understood. Objective To characterize components of the intrarenal renin‐angiotensin system (RAS) in cats with CKD.
Bianca N. Lourenço, Amanda E. Coleman, Roy D. Berghaus, Jaime L. Tarigo, Chad W. Schmiedt, Scott A. Brown   +5 more
doaj   +1 more source