Results 251 to 260 of about 206,446 (295)

Clinical Relevance and Diagnostic Utility of Standard Serum Biomarkers in Advanced Chronic Kidney Disease: A Single‐Center Observational Study From Bangladesh

iLABMED, EarlyView.
This study evaluated conventional and emerging biochemical markers for assessing chronic kidney disease (CKD) progression in Bangladeshi patients elevated serum uric acid and parathyroid hormone levels, along with reduced eGFR, vitamin D, and albumin levels, were significantly associated with CKD, highlighting their potential as cost‐effective early ...
Fazlul Haque, Md. Samiul Islam, Nafsoon Rahman, Ayub Zawad, Sadia Afrin, Pulak Kanti Palit, Tanjil Hasan, Md. Isahak Ali, Shafin Ahmed, Akram Hossain, Marina Khatun, Tabassuma Marzia Prome, Md. Shah Alam, Ashekul Islam   +13 more
wiley   +1 more source

Endometrial Stromal Cell Senescence: A Non‐Negligible Factor in Recurrent Pregnancy Loss

iMetaMed, EarlyView.
As populations age, links between female reproductive aging and infertility are increasingly evident. Cellular senescence, characterized by near‐irreversible cell‐cycle arrest and accumulation of damage, can impair tissue function. In the endometrium, aberrant senescence of endometrial stromal cells (EnSCs) may compromise receptivity, hinder embryo ...
Shuang Wu, Cenlan Bu, Qinzheng Xu, Xi Cheng, Junrong Zhang, Jinling Chen, Yun‐Zhao Xu   +6 more
wiley   +1 more source

Isorhamnetin Alleviates Renal Fibrosis Induced by Renal Tubular Epithelial Cell Senescence Via Inhibition of the IL‐6/IL‐6R Signaling Pathway

iMetaMed, EarlyView.
IL‐6 from RTECs upregulates TGF‐β in macrophages, promoting fibroblast transdifferentiation. Isorhamnetin inhibits this effect. ABSTRACT Chronic kidney disease (CKD) is a major global health issue. Kidney fibrosis is a key mechanism leading to end‐stage renal disease.
Weifei Liang, Xiangqiu Chen, Tao Wu, Xichun Zheng, Shaohua Zeng, Qingchun Zhou, Wen Ma, Hao Lin, Donglin Sun   +8 more
wiley   +1 more source

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Conversion of Angiotensin I to Angiotensin II

Nature, 1967
Results obtained with the blood bathed organ technique indicate that angiotensin I is converted rapidly to angiotensin II in the pulmonary circulation and not by an enzyme in the blood.
K K, Ng, J R, Vane
openaire   +2 more sources

Conversion of angiotensin I to angiotensin II

The American Journal of Medicine, 1976
The angiotensin I converting enzyme has two important functions: it inactivates bradykinin and converts angiotensin I to angiotensin II. Inhibition of the enzyme blocks the renin-angiotensin system and decreases systemic blood pressure if the pressure is maintained or increased by renin. The enzyme occurs in a variety of tissues and cell forms.
openaire   +3 more sources

Human Leukocytes Contain Angiotensin I, Angiotensin II and Angiotensin Metabolites

International Archives of Allergy and Immunology, 1994
Angiotensin I (ANG I) and angiotensin II (ANG II) were measured radioimmunologically in human leukocytes extracted with a mixture of acetone, 1N HCl and water (40:1:10 vol). The analytical recoveries of 125I-ANG I and 125I-ANG II, which were added prior to extraction, were 92.00 +/- 3.10 and 99.19 +/- 0.91% (mean +/- SEM; n = 12).
K, Hermann, J, Ring
openaire   +2 more sources

Pressor Response to Angiotensin I and Angiotensin II: The Site of Conversion of Angiotensin I

Clinical Science, 1972
1. The pressor responses to angiotensin I were compared with those to angiotensin II after injections into the left ventricle and jugular vein in the sheep, dog and pig. 2. The ability of angiotensin I to raise the blood pressure was less than that of angiotensin II with both routes of injection, a difference which was more marked after ...
E C, Osborn, G, Tildesley, P T, Pickens
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Enzyme Immunoassay of Angiotensin I

Endocrinology, 1979
A very sensitive and specific enzyme immunoassay has been developed for angiotensin I. Angiotensin I was coupled to beta-D-galactosidase by a novel cross-linking reagent, N-(meta-maleimidobenzoyloxy)succinimide. No decrease in the enzyme activity was observed during the coupling procedure.
T, Aikawa, S, Suzuki, M, Murayama, K, Hashiba, T, Kitagawa, E, Ishikawa   +5 more
openaire   +2 more sources

Intrarenal Formation of Angiotensin I

Science, 1971
In 5 patients and 16 dogs the mean concentration of angiotensin I, but not II, was higher in the plasma of the renal vein than in the plasma of the renal artery. The fact that I was higher in the vein than in the artery supports the concept that I is formed in the renal vasculature.
H D, Itskovitz, C, Odya
openaire   +2 more sources

CONVERSION OF ANGIOTENSIN I TO ANGIOTENSIN II IN SHEEP

Clinical and Experimental Pharmacology and Physiology, 1978
SUMMARY1. The methodology for measurement of angiotensin I in whole blood is described.2. Angiotensin I was measured in arterial and venous blood samples from sodium‐loaded, sodium‐replete and sodium‐depleted sheep. Venous blood concentrations were higher than arterial angiotensin I concentrations.
R T, Fernley, J P, Coghlan, E J, Cran, T W, Fei, B A, Scoggins, A, McGregor   +5 more
openaire   +2 more sources