Results 261 to 270 of about 221,266 (311)
Intrarenal vascular effects of angiotensin I and angiotensin II
American Journal of Physiology-Heart and Circulatory Physiology, 1981 The effects of angiotensin I (250 pmol) and angiotensin II (7.5 pmol) on total renal blood flow and its cortical distribution were examined in 25 dogs anesthetized with pentobarbital. These peptides were administered as bolus injections directly into the left renal artery.
S. L. Britton
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Conversion of Angiotensin I to Angiotensin II
Nature, 1967Results obtained with the blood bathed organ technique indicate that angiotensin I is converted rapidly to angiotensin II in the pulmonary circulation and not by an enzyme in the blood.
K K, Ng, J R, Vane
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Pressor Response to Angiotensin I and Angiotensin II: The Site of Conversion of Angiotensin I
Clinical Science, 19721. The pressor responses to angiotensin I were compared with those to angiotensin II after injections into the left ventricle and jugular vein in the sheep, dog and pig. 2. The ability of angiotensin I to raise the blood pressure was less than that of angiotensin II with both routes of injection, a difference which was more marked after ...
E C, Osborn, G, Tildesley, P T, Pickens
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CONVERSION OF ANGIOTENSIN I TO ANGIOTENSIN II IN SHEEP
Clinical and Experimental Pharmacology and Physiology, 1978SUMMARY1. The methodology for measurement of angiotensin I in whole blood is described.2. Angiotensin I was measured in arterial and venous blood samples from sodium‐loaded, sodium‐replete and sodium‐depleted sheep. Venous blood concentrations were higher than arterial angiotensin I concentrations.
R T, Fernley +5 more
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Conversion of angiotensin I to angiotensin II
The American Journal of Medicine, 1976The angiotensin I converting enzyme has two important functions: it inactivates bradykinin and converts angiotensin I to angiotensin II. Inhibition of the enzyme blocks the renin-angiotensin system and decreases systemic blood pressure if the pressure is maintained or increased by renin. The enzyme occurs in a variety of tissues and cell forms.
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Human Leukocytes Contain Angiotensin I, Angiotensin II and Angiotensin Metabolites
International Archives of Allergy and Immunology, 2009Angiotensin I (ANG I) and angiotensin II (ANG II) were measured radioimmunologically in human leukocytes extracted with a mixture of acetone, 1N HCl and water (40:1:10 vol). The analytical recoveries of 125I-ANG I and 125I-ANGII, which were added prior to extraction, were 92.00 ± 3.I0 and 99.19 ± 0.91% (mean ± SEM; n = 12).
K, Hermann, J, Ring
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Duplexed iMALDI for the detection of angiotensin I and angiotensin II
Methods, 2012An immuno-Matrix Assisted Laser Desorption/Ionization (iMALDI) method has been developed using anti-IgG beads to capture anti-AngI and anti-AngII antibodies, which are incubated with a ∼50μL plasma sample to which known amounts of stable-isotope-labeled AngI and AngII have been added. After a short incubation time, the beads are washed, placed directly
D Randal, Mason +4 more
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Fate of Angiotensin I in the Circulation
Nature, 1968The blood-bathed organ technique has been used to demonstrate that angiotensin I is converted to angiotensin II in the lungs, but not in other vascular beds. The results do not support hypotheses which suggest a completely intra-renal role for the renin–angiotensin system.
K K, Ng, J R, Vane
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Enzyme Immunoassay of Angiotensin I
Endocrinology, 1979A very sensitive and specific enzyme immunoassay has been developed for angiotensin I. Angiotensin I was coupled to beta-D-galactosidase by a novel cross-linking reagent, N-(meta-maleimidobenzoyloxy)succinimide. No decrease in the enzyme activity was observed during the coupling procedure.
T, Aikawa +5 more
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Des-asp1-angiotensin I: A metabolite of angiotensin I in the perfused feline adrenal
European Journal of Pharmacology, 1976The administration of radioactive angiotensin I to the retrogradely perfused feline adrenal gland caused a brisk discharge of catecholamines. Recovery of the labelled decapeptide and metabolites in the adrenal effluent fluid was complete in 5 min.
J A, Ackerly, T S, Felger, M J, Peach
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