Results 21 to 30 of about 206,446 (295)

From Angiotensin II to Cyclic Peptides and Angiotensin Receptor Blockers (ARBs): Perspectives of ARBs in COVID-19 Therapy

Molecules, 2021
The octapeptide hormone angiotensin II is one of the most studied peptides with the aim of designing and synthesizing non-peptide mimetics for oral administration.
John Matsoukas, Vasso Apostolopoulos, Anthony Zulli, Graham Moore, Konstantinos Kelaidonis, Kalliopi Moschovou, Thomas Mavromoustakos   +6 more
doaj   +1 more source

Effects of the selective chymase inhibitor TEI‐F00806 on the intrarenal renin–angiotensin system in salt‐treated angiotensin I‐infused hypertensive mice

Experimental Physiology, 2018
New Findings What is the central question of this study? Can chymase inhibition prevent angiotensin I‐induced hypertension through inhibiting the conversion of angiotensin I to angiotensin II in the kidney?
Tuba M. Ansary, Maki Urushihara, Yoshihide Fujisawa, Sayaka Nagata, Hidenori Urata, Daisuke Nakano, Hitomi Hirofumi, Kazuo Kitamura, Shoji Kagami, Akira Nishiyama   +9 more
doaj   +1 more source

Ethanolic Extract of Salvia hispanica L. Regulates Blood Pressure by Modulating the Expression of Genes Involved in BP-Regulatory Pathways

Molecules, 2020
Hypertension (HT) is considered to be a potential risk factor for cardiovascular diseases and has been directly related to pathologies such as obesity and dyslipidemias.
Gerardo I. Arredondo-Mendoza, Zacarías Jiménez-Salas, Francisco Javier Guzmán-de la Garza, Elizabeth Solís-Pérez, Manuel López-Cabanillas-Lomelí, Blanca Edelia González-Martínez, Eduardo Campos-Góngora   +6 more
doaj   +1 more source

Alterations in the Renin-Angiotensin System in Experimental Septic Shock

Critical Care Explorations
OBJECTIVES:. To analyze dynamic changes in the renin-angiotensin system (RAS) during septic shock, focusing on angiotensin-converting enzyme (ACE) activity and the balance between angiotensin peptides, using a mass spectrometry method.
Bruno Garcia, MD, PhD, Benoit Ter Schiphorst, MD, MSc, Fuhong Su, MD, PhD, Adrien Picod, MD, PhD, Theo Ikenna-Uba, PhD, Raphaël Favory, MD, PhD, Filippo Annoni, MD, Alexandre Mebazaa, MD, PhD, Jean-Louis Vincent, MD, PhD, Jacques Creteur, MD, PhD, Fabio S. Taccone, MD, PhD, Antoine Herpain, MD   +11 more
doaj   +1 more source

Classical and Alternative Pathways of the Renin–Angiotensin–Aldosterone System in Regulating Blood Pressure in Hypertension and Obese Adolescents

Biomedicines
Primary hypertension (PH) is the leading form of arterial hypertension (AH) in adolescents. Hypertension is most common in obese patients, where 20 to 40% of the population has elevated blood pressure.
Adrian Martyniak, Dorota Drożdż, Przemysław J. Tomasik   +2 more
doaj   +1 more source

Captopril Enhances Cardiac Vagal but Not Sympathetic Neurotransmission in Pithed Rats

Journal of Pharmacological Sciences, 2004
The effect of captopril on neurally evoked bradycardia and tachycardia was investigated in pithed rats. Captopril enhanced the vagal nerve stimulation-evoked bradycardia.
Yoshinobu Takata, Takanori Arai, Shigeto Suzuki, Junichi Kurihara, Takashi Uezono, Yoko Okubo, Hitoshi Kato   +6 more
doaj   +1 more source

Clinical Outcomes of Angiotensin II Therapy in Vasoplegic Shock: A Systematic Review and Meta-Analysis

Life
Background: Angiotensin II is a peptide hormone vasopressor that activates angiotensin type 1 (AT1) receptors leading to vasoconstriction, the augmentation of arterial blood pressure (ABP), and organ perfusion.
Ans Alamami, Alaa Rahhal, Bara Alqudah, Ahmed Shebani, Abdelkarim Alammora, Hashim Mohammad, Amr S. Omar, Ahmed Labib Shehatta   +7 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Role of cardiac renin angiotensin system in ischemia reperfusion injury and preconditioning of heart

Indian Heart Journal, 2016
Cardio-vascular diseases are the leading cause of morbidity and mortality. Ischemia is a state of oxygen deprivation in tissues, whereas reperfusion is restoration of blood flow in ischemic tissues.
Vimal Agrawal, Jeetendra Kumar Gupta, Shaiba Sana Qureshi, Vishal Kumar Vishwakarma   +3 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source