Results 131 to 140 of about 262,681 (286)
British Journal of Clinical Pharmacology, EarlyView.Aim This study builds on the environmental risk analysis presented in the 2022 National Report on Medicines Use in Italy by the Italian Medicines Agency and aims to assess the environmental risk posed by medicines in Italy and its regions. Methods The analysis selected 90 medicines based on three criteria: high utilization, low predicted no effect ...
Valentina Giunchi +8 more
wiley +1 more source
Semiparametric Joint Modeling to Estimate the Treatment Effect on a Longitudinal Surrogate with Application to Chronic Kidney Disease Trials [PDF]
arXivIn clinical trials where long follow-up is required to measure the primary outcome of interest, there is substantial interest in using an accepted surrogate outcome that can be measured earlier in time or with less cost to estimate a treatment effect.
arxiv
The contribution of extracellular RNA and its derived biomaterials in disease management
BMEMat, EarlyView.The implications of exRNA's biological function and the structural uniqueness of RNA help establish a close connection between RNA, material, and modern medicine. Abstract The RNA found in the circular system is known as extracellular RNA (exRNA). This kind of RNA has been found to play a biological role similar to that of a messenger. They can be used
Yu Wei +8 more
wiley +1 more source
Liver organoids: From 3D printing to biomedical applications
BMEMat, EarlyView.A comprehensive review on liver organoids culture techniques from 3D printing to organ‐on‐chip, as well as focusing on challenges and perspectives for advancement liver organoids in various future applications. Abstract The liver is an immune organ, especially an immune tolerance organ.
Ying Shi +4 more
wiley +1 more source
Journal of Pharmacological Sciences, 2013 Angiotensin II (Ang II) infusion into rats elevates local angiotensin II levels through an AT1 receptor–dependent pathway in the kidney. We examined whether treatment with an angiotensin-converting enzyme (ACE) inhibitor, temocapril, or an AT1-receptor ...
Keisuke Ohnishi +12 more
doaj
The accessory renal arteries: A systematic review with meta‐analysis
Clinical Anatomy, EarlyView.Abstract The accessory renal arteries (ARAs) are a well‐described variant of the renal vasculature with clinical implications for radiologists, surgeons, and clinicians. The aim of the present systematic review with meta‐analysis was to estimate the pooled prevalence of ARAs, including their variant number, origin, and termination, and to highlight ...
George Triantafyllou +6 more
wiley +1 more source
Multiple Mechanisms for the Action of Chymase Inhibitors
Journal of Pharmacological Sciences, 2012 Angiotensin II plays an important role in regulating blood pressure. Moreover, angiotensin II directly promotes organ damage by inducing expression of various genes, such as transforming growth factor (TGF)-β and matrix metalloproteinase (MMP)-9 ...
Shinji Takai, Denan Jin, Mizuo Miyazaki
doaj
Serotonergic modulators in Alzheimer's disease: a hope in the hopeless condition
Chemistry &Biodiversity, Accepted Article.Alzheimer disease (AD) is the main cause of dementia worldwide. AD is a progressive brain neurodegenerative disease due to genetic and environmental factors that induce a progressive accumulation of intracellular hyperphosphorylated tau protein and extracellular amyloid protein (Aβ).
Ali I. Al-Gareeb +5 more
wiley +1 more source
Open Access Emergency Medicine, 2010 T S Mohamed Saleem1, K Bharani1, K Gauthaman21Department of Pharmacology, Annamacharya College of Pharmacy, Rajampet-516126, Kadapa Dist, Andhra Pradesh, India; 2Department of Drug Technology, Higher Institute of Medical Technology, Derna, LibyaAbstract:
T S Mohamed Saleem +2 more
doaj
Lienhwalides: Unique Tropolone–Maleidride Hybrids from Hypoxylon lienhwacheense
ChemBioChem, EarlyView.Lienhwalides are novel tropolone–maleidride hybrid molecules unique in nature. Absolute configuration is solved by semisynthetic approaches and X‐ray analysis. Interplay between both lwt and lwm biosynthetic gene clusters is responsible for the production of lienhwalides.
Katharina Schmidt +13 more
wiley +1 more source