Results 131 to 140 of about 4,825,321 (354)

Angiotensin II and taste sensitivity

open access: yesJapanese Dental Science Review, 2015
SummaryThe sense of taste plays a major role in evaluating the quality of food components in the oral cavity. Sweet, salty, umami, sour and bitter taste are generally accepted as five basic taste qualities. Among them, salty taste is attractive to animals and influences sodium intake.
openaire   +3 more sources

Multiple low dose streptozotocin‐induced diabetes as a model for studying autoimmune diabetes in humans

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Multiple low dose streptozotocin‐induced diabetes is a valuable animal model of diabetes type 1. It should be improved by further research on autoantigens, microbiota and mucosal immune cells from the gut, but also from other organs. Abstract The autoimmune response directed against pancreatic β cells is the most essential pathogenic process in type 1 ...
Ivan Koprivica   +4 more
wiley   +1 more source

Long‐Circulating Nanobody Confers Durable Prophylaxis against Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Infection

open access: yesAdvanced NanoBiomed Research, EarlyView.
This study explores Fc engineering to extend nanobody half‐lives in vivo. Herein, it is demonstrated that the circulation half‐life of Nanosota‐3A‐Fc, a novel nanobody with potent neutralizing activity against SARS‐CoV‐2 Omicron BA.1 variant, can be greatly prolonged by introducing M252Y/S254T/T256E (YTE) substitutions in the IgG1 Fc domain, which ...
Geetha Jyothi Vaskuri   +9 more
wiley   +1 more source

Die Umlenkung der Peptidspaltung führt zur Protease‐Inaktivierung

open access: yesAngewandte Chemie, EarlyView.
Cysteinproteasen katalysieren die Substratspaltung im Zuge eines zweistufigen Acyltransfers. Die neuartigen peptidischen Inhibitoren von humanem Cathepsin B mit einer N‐terminalen Carbamat‐Kopfgruppe erfahren eine Umlenkung der Peptidspaltung und bilden nicht‐kanonische kovalente Komplexe.
Christian Breuer   +20 more
wiley   +1 more source

Angiotensin II for the Treatment of Vasodilatory Shock

open access: yesNew England Journal of Medicine, 2017
A. Khanna   +32 more
semanticscholar   +2 more sources

Angiotensin-Converting Enzyme Inhibitor Does Not Suppress Renal Angiotensin II Levels in Angiotensin I–Infused Rats

open access: yesJournal of Pharmacological Sciences, 2013
Angiotensin II (Ang II) infusion into rats elevates local angiotensin II levels through an AT1 receptor–dependent pathway in the kidney. We examined whether treatment with an angiotensin-converting enzyme (ACE) inhibitor, temocapril, or an AT1-receptor ...
Keisuke Ohnishi   +12 more
doaj  

Mechanochemical Strategies Applied to the Late‐Stage Modifications of Pharmaceutically Active Compounds

open access: yesAngewandte Chemie International Edition, Accepted Article.
This review explores the potential of mechanochemistry in the late‐stage modification of active pharmaceutical ingredients (APIs), offering a comprehensive analysis of methods designed to transform structurally complex molecular scaffolds. By examining the scope, efficiency, and mechanistic aspects of these approaches, the review highlights protocols ...
Johanna Templ, Lars Borchardt
wiley   +1 more source

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