Results 131 to 140 of about 5,061,790 (379)
Renin-Angiotensin System Blockers and the COVID-19 Pandemic
HYPERTENSION, 2020 During the spread of the severe acute respiratory syndrome coronavirus-2, some reports of data still emerging and in need of full analysis indicate that certain groups of patients are at risk of COVID-19.
A. Danser, M. Epstein, D. Batlle
semanticscholar +1 more source
Newly identified NO-sensor guanylyl cyclase/connexin 43 association is involved in cardiac electrical function [PDF]
, 2017 Background: Guanylyl cyclase, a heme-containing alpha 1 beta 1 heterodimer (GC1), produces cGMP in response to Nitric oxide (NO) stimulation. The NO-GC1-cGMP pathway negatively regulates cardiomyocyte contractility and protects against cardiac ...
Beuve, Annie +7 more
core +2 more sources
A Touch Enabled Hemodynamic and Metabolic Monitor
Advanced Science, EarlyView.This work presents a touch‐based hybrid platform for simultaneous monitoring of vital signs and sweat metabolites. With a simple tri‐finger touch of 4–6 min, users can concurrently get to know their glucose, uric acid, cortisol levels from fingertip sweat, along with blood pressure and heart rate.
Omeed Djassemi +19 more
wiley +1 more source
Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice.
Journal of Clinical Investigation, 2000 Increased plasma concentrations of angiotension II (Ang II) have been implicated in atherogenesis. To examine this relationship directly, we infused Ang II or vehicle for 1 month via osmotic minipumps into mature apoE(-/-) mice. These doses of Ang II did
A. Daugherty +2 more
semanticscholar +1 more source
Advanced Science, EarlyView.Abnormal mechanical stretch induced by mechanical ventilation (MV) disrupts endothelial junctions via the NOX2/ROS/CaMKII/ERK1/2 axis both in human aortic endothelial cells (HAECs) in vitro and in ventilator‐induced lung injury (VILI) in mice. Quercetin, an antioxidant predicted to bind to NOX2, can effectively prevent mechanical stretch‐induced ...
Tao Jiang +8 more
wiley +1 more source
Influence of angiotensin II receptor blocker combination tablet prescription on drug number and cost
SAGE Open Medicine, 2014 Objectives: Combination therapy using an angiotensin II receptor blocker is expected to promote medication adherence and alleviate economic burden among patients by reducing the number of drugs taken, and thereby to lower associated medical costs. In the
Hitomi Teramachi +8 more
doaj +1 more source
Designing a Prospective COVID-19 Therapeutic with Reinforcement Learning [PDF]
arXiv, 2020 The SARS-CoV-2 pandemic has created a global race for a cure. One approach focuses on designing a novel variant of the human angiotensin-converting enzyme 2 (ACE2) that binds more tightly to the SARS-CoV-2 spike protein and diverts it from human cells. Here we formulate a novel protein design framework as a reinforcement learning problem.
arxiv
Angiotensin II, NADPH oxidase, and redox signaling in the vasculature.
Antioxidants and Redox Signaling, 2013 SIGNIFICANCE Angiotensin II (Ang II) influences the function of many cell types and regulates many organ systems, in large part through redox-sensitive processes.
A. Nguyen Dinh Cat +3 more
semanticscholar +1 more source
Advanced Science, EarlyView.This study develops a human engineered heart tissue‐derived model of diabetic cardiomyopathy that accurately replicates the dynamic changes in the structural, contractile, and electrophysiological properties of the myocardium. Furthermore, this model is used to confirm the direct protective effects of empagliflozin on the heart through an SGLT2 off ...
Lin Cai +9 more
wiley +1 more source
Antihypertensive effects of angiotensin-(1-7)
Brazilian Journal of Medical and Biological Research, 1998 Accumulating evidence suggests that angiotensin-(1-7) (Ang-(1-7)) is an important component of the renin-angiotensin system and that the actions of the peptide may either contribute to or oppose those of Ang II.
M.C. Chappell +3 more
doaj +1 more source