Results 141 to 150 of about 4,825,321 (354)
Tissue Angiotensin II Generating System by Angiotensin-Converting Enzyme and Chymase
Journal of Pharmacological Sciences, 2006 .: It had been believed that angiotensin II (Ang II) was produced by the renin-angiotensin system (RAS), which was established in the 1950’s. After a while, people realized that the multiple functions of Ang II could not be explained by the conventional ...
Mizuo Miyazaki, Shinji Takai
doaj
Evaluation of the Pressor, Cardiac, and Renal Hemodynamic Properties of Angiotensin II in Man [PDF]
, 1961 Frank A. Finnerty +3 more
openalex +1 more source
Redirecting the Peptide Cleavage Causes Protease Inactivation
Angewandte Chemie International Edition, EarlyView.Cysteine proteases catalyze substrate cleavage by a two‐step acyl transfer mechanism. Newly designed peptidic inhibitors of human cathepsin B with N‐terminal carbamate warheads undergo a redirected cleavage and generate non‐canonical covalent complexes.
Christian Breuer +20 more
wiley +1 more source
Multiple Mechanisms for the Action of Chymase Inhibitors
Journal of Pharmacological Sciences, 2012 Angiotensin II plays an important role in regulating blood pressure. Moreover, angiotensin II directly promotes organ damage by inducing expression of various genes, such as transforming growth factor (TGF)-β and matrix metalloproteinase (MMP)-9 ...
Shinji Takai, Denan Jin, Mizuo Miyazaki
doaj
INCREASED SUSCEPTIBILITY TO PYELONEPHRITIS DURING ACUTE HYPERTENSION BY ANGIOTENSIN II AND NOREPINEPHRINE* [PDF]
, 1963 R. K. Jones, Alvin P. Shapiro
openalex +1 more source
Case Reports in Critical CareConclusion: Despite evidence of efficacy in refractory vasodilatory shock secondary to sepsis, there is a paucity of data on the use of angiotensin II as an adjunctive vasopressor in drug-induced shock.
John H. Keller +2 more
doaj +1 more source
Simulation of Spontaneous Secondary Hyperaldosteronism by Intravenous Infusion of Angiotensin II in Dogs with an Arteriovenous Fistula* [PDF]
, 1964 John Urquhart +2 more
openalex +1 more source
Arthritis &Rheumatology, EarlyView.Objective This study characterized the impact of voclosporin on kidney histology in patients with lupus nephritis (LN) who had protocolized repeat kidney biopsies in the AURORA clinical trials. Methods Patients were randomized to voclosporin or placebo treatment for up to 3 years; all patients received mycophenolate mofetil and low‐dose glucocorticoids.
Brad H. Rovin +9 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Aim Heart transplantation (HT) is frequently complicated by chronic kidney disease, of which tacrolimus‐related nephrotoxicity is an important cause. In kidney and liver transplant recipients, fast tacrolimus metabolism (defined as a low concentration‐to‐dose [C0/D] ratio), negatively affects kidney function.
Maaike R. Schagen +9 more
wiley +1 more source
Effects of a crystalline proteinase fromBacillus subtilis (Nagarse) on angiotensins I and II [PDF]
, 1966 Ryo Endo, M. Santos, E.A. Carlini
openalex +1 more source