Results 221 to 230 of about 136,173 (262)

Expression of type 1 angiotensin II receptors in human aldosteronomas

Endocrine Research, 1995
Type 1 angiotensin II (AII) receptors (AT1 receptors), besides stimulation of aldosterone secretion, seem to transduce the growth factor-like activity of AII on glomerulosa cells. Although a local renin-angiotensin system and AII synthesis have been found in human adrenals and aldosteronomas, it is unclear whether aldosteronomas express AT1 receptors ...
R. SARZANI, OPOCHER, GIUSEPPE, P. DESSIFULGHERI, V. PACI, G. COLA, S. ROCCO, B. VIANELLO, MANTERO, FRANCO, A. RAPPELLI   +8 more
openaire   +2 more sources

Gene Polymorphism of Angiotensin II Type 1 and Type 2 Receptors

Current Pharmaceutical Design, 2013
Renin-angiotensin system (RAS) plays a key role in pathogenesis of cardiovascular disease and in the responsiveness for various types of medications. A large number of genetic investigations have been carried out to examine the association between gene variants of RAS and predisposition to cardiovascular diseases, such as hypertension, coronary artery ...
Tomohiro, Katsuya, Ryuichi, Morishita
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The distribution of angiotensin II type 1 receptors, and the tissue renin-angiotensin systems

Molecular Medicine Today, 1995
Since its discovery, the functions of the renin-angiotensin system (RAS) have attracted a great deal of attention, and the roles it plays under normal conditions, and in disease, acquire a deepening significance with every year. In general, the RAS has been considered largely in terms of its roles in sodium and potassium homeostasis and the regulation ...
G P, Vinson, M M, Ho, J R, Puddefoot
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Type 1 angiotensin II receptors in rat and human sperm

Journal of Endocrinology, 1995
Abstract The physiological factors which induce and maintain mammalian sperm maturation and motility generally remain unclear, although several agents are known to be involved. We describe here the application of immunocytochemical and immunoblotting methods to identify the angiotensin II type 1 (AT1) receptor in the tails of ...
G P, Vinson, J R, Puddefoot, M M, Ho, S, Barker, J, Mehta, E, Saridogan, O, Djahanbakhch   +6 more
openaire   +2 more sources

[Angiotensin II type 1 and type 2 receptor].

Nihon rinsho. Japanese journal of clinical medicine, 2009
The octapeptide angiotensin II (AngII) plays a homeostatic role in the regulation of blood pressure and water and electrolyte balance, and contributes to the progression of cardiovascular remodeling. AngII activates AngII type 1 (AT1) receptor and type 2 (AT2) receptor, both of which belong to the seven-transmembrane, G protein-coupled receptor family.
Hiroshi, Akazawa, Issei, Komuro
openaire   +1 more source

Evidence for the presence of angiotensin II-type 1 receptors in brain

Brain Research Bulletin, 1990
Angiotensin II receptor subtypes have been localized in brain by using a novel nonpeptide AII-type 1 receptor antagonist to compete with [125I]AII binding in an autoradiographic study. These data contrast with results obtained using the AII-type 2 antagonist PD123177.
J K, Wamsley, W F, Herblin, M E, Alburges, M, Hunt   +3 more
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The Angiotensin II Type 1 Receptor Antagonists

Archives of Internal Medicine, 1995
The angiotensin II (AII) type 1 receptor antagonists represent a new pharmacologic class of drugs that are specifically designed to displace All from its type 1 receptor subtype. These drugs antagonize AII-induced biologic actions, including smooth-muscle contraction, sympathetic pressor mechanisms, and aldosterone release.
openaire   +1 more source

Cloning and characterization of a human angiotensin II type 1 receptor

Biochemical and Biophysical Research Communications, 1992
A human liver cDNA library was screened using a rat type 1 angiotensin II receptor cDNA coding sequence as a probe. cDNA clones were isolated which encoded a protein of 359 amino acids that shared 94.4% and 95.3% identify to rat and bovine type 1 angiotensin II receptors, respectively.
D J, Bergsma, C, Ellis, C, Kumar, P, Nuthulaganti, H, Kersten, N, Elshourbagy, E, Griffin, J M, Stadel, N, Aiyar   +8 more
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The Genomic Organization of Human Angiotensin II Type 1 Receptor

Biochemical and Biophysical Research Communications, 1994
As a step toward the elucidation of human Ang II type 1 receptor gene expression, the genomic organization of the human AT1 receptor was investigated. Comparison of the genomic DNA and cDNA sequences revealed that it consists of at least five exons. The length of the AT1 receptor gene is greater than 55 kb, and the size of the exons ranges from 59 to 2,
D F, Guo, H, Furuta, M, Mizukoshi, T, Inagami   +3 more
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Role of Type 1 and Type 2 Angiotensin Receptors in Angiotensin II–Induced Cardiomyocyte Hypertrophy

Hypertension, 1996
We compared the ability of angiotensin II (Ang II) to induce hypertrophy of neonatal rat ventricular myocytes with that of endothelin-1. Over 72 hours, Ang II (1 μmol/L) increased the ratio of protein to DNA by less than 10%, whereas endothelin-1 (100 nmol/L) produced a 28% increase.
G W, Booz, K M, Baker
openaire   +2 more sources