Results 61 to 70 of about 272,686 (351)

Angiotensin II promotes melanogenesis via angiotensin II type 1 receptors in human melanocytes

Molecular Medicine Reports, 2012
Angiotensin II (AngII) is a hormone with long-established cardiovascular actions. Previous studies have revealed an additional role for AngII in the regulation of cutaneous wound healing. To evaluate the association between AngII and abnormal pigmentation of cutaneous wound healing, the present study used human melanocytes to investigate the effects of
Li-Hong, Liu, Xin, Fan, Hai-Tao, Li, Xu-Xi, An, Rong-Ya, Yang   +4 more
openaire   +3 more sources

Preeclampsia, the Renin-Angiotensin-Aldosterone System and beyond [PDF]

, 2015
__Abstract__ The renin-angiotensin-aldosterone system (RAAS) plays an essential role in the regulation of blood pressure and body fluid homeostasis, but also contributes importantly to the pathophysiology of hypertension, renal disease and heart ...
Verdonk, K. (Koen)
core   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Renal denervation inhibits the renin–angiotensin–aldosterone system in spontaneously hypertensive rats

Clinical and Experimental Hypertension, 2022
This study was conducted to explore the effect of renal denervation (RDN) on the renin–angiotensin–aldosterone system (RAAS) in spontaneously hypertensive rats (SHRs).
Fei Qin, Jianling Li, Yong-Fa Dai, Xiao-ge Zhong, Ya-jin Pan   +4 more
doaj   +1 more source

ACE2-angiotensin-(1-7)-Mas axis in renal ischaemia/reperfusion injury in rats [PDF]

, 2010
AngII (angiotensin II), ACE (angiotensin I-converting enzyme) and the AT(1) receptor (AngII type I receptor) are associated with the inflammatory process and microvascular dysfunction of AKI (acute kidney injury) induced by renal I/R (ischaemia ...
Adriana K. Carmona, Allred, Ana C. Simões e Silva, Araújo, Botelho, Bradford, Burchill, Burrell, Carey, Chappell, Donoghue, Edelstein, Ferrario, Gembardt, Giovanni D. Cassali, Goulter, Ishiyama, Jerkić, Kontogiannis, Kostenis, Kwon, Kátia D. da Silveira, Kênia S. Pompermayer Bosco, Lely, Lirlândia P. de Sousa, Lúcio R. L. Diniz, Mackie, Maria A. Ribeiro Vieira, Mauro M. Teixeira, Mercure, Molitoris, Oscar Bruna-Romero, Pereira, Pinheiro, Pompermayer, Rice, Robson A. S. Santos, Ruiz-Ortega, Sampaio, Santos, Santos, Santos, Santos, Simões e Silva, Su, Tallant, Tallant, Tikellis, Tipinis, Velkoska, Versteilen, Villanueva   +51 more
core   +2 more sources

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Angiotensin II upregulates type-1 angiotensin II receptors in renal proximal tubule. [PDF]

Journal of Clinical Investigation, 1995
Angiotensin II (Ang II) is an important regulator of proximal tubule salt and water reabsorption. Recent studies indicate that rabbit proximal tubule angiotensin II receptors are the type-1 (AT1R) subtype. We studied the effect of Ang II on proximal tubule receptor expression. Rabbits were treated with either angiotensin converting enzyme inhibitors or
H F, Cheng, B N, Becker, K D, Burns, R C, Harris   +3 more
openaire   +2 more sources

Angiotensin-(1–1) Suppresses Hepatocellular Carcinoma Growth and Angiogenesis via Complex Interactions of Angiotensin II Type 1 Receptor, Angiotensin II Type 2 Receptor and Mas Receptor

Molecular Medicine, 2015
We recently confirmed that angiotensin II (Ang II) type 1 receptor (AT1R) was overexpressed in hepatocellular carcinoma tissue using a murine hepatoma model. Angiotensin(Ang)-(1-7) has been found beneficial in ameliorating lung cancer and prostate cancer.
Yanping Liu, Bin Li, Ximing Wang, Guiying Li, Rui Shang, Jianmin Yang, Jia-li Wang, Meng Zhang, Yuguo Chen, Yun Zhang, Cheng Zhang, Panpan Hao   +11 more
semanticscholar   +1 more source

Angiotensin-converting enzyme 2 is reduced in Alzheimer's disease in association with increasing amyloid-β and tau pathology [PDF]

, 2016
BACKGROUND: Hyperactivity of the classical axis of the renin-angiotensin system (RAS), mediated by angiotensin II (Ang II) activation of the angiotensin II type 1 receptor (AT1R), is implicated in the pathogenesis of Alzheimer’s disease (AD). Angiotensin-
Al Mulhim, Noura S K, Kehoe, Patrick Gavin, Miners, J Scott, Palmer, Laura Elyse, Wong, Steffenny   +4 more
core   +3 more sources

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source