Results 41 to 50 of about 131,203 (163)

Modeling Angiotensin II‐mediated activation of the Angiotensin II Type 1 Receptor

The FASEB Journal, 2018
It is well known that agonist binding to GPCRs engages a structural rearrangement, leading to GDP disassociation from the G‐alpha subunit and subsequent GTP association and activation of the Gα subunit. However, the structural mechanism mediating intramolecular molecular communication between the agonist binding pocket and G‐alpha ...
Shane D. Anderson, Wesley M. Botello‐Smith, Yun Lyna Luo, Bradley T. Andresen   +3 more
openaire   +1 more source

Therapeutic targets of renin-angiotensin system in ocular disorders

Journal of Current Ophthalmology, 2017
Purpose: To review current literature on the renin-angiotensin system (RAS)-mediated pathogenic mechanisms and therapeutic targets in ocular diseases.
Rajesh Choudhary, Mandeep Singh Kapoor, Amrita Singh, Surendra H. Bodakhe   +3 more
doaj   +1 more source

Renin-Angiotensin A1166C Polymorphism and the Rrisk of Stroke [PDF]

Journal of Cell and Molecular Research, 2015
Stroke is the leading cause of death and disability in the world after the cancer and cardiovascular diseases. Genetic factors have main significance to got stroke.
Peyman Zargari, Mohammad R. Ghasemi, Maryam Pirhoushiaran, Veda Vakili, Javad Hami, Mohammad Taghi Farzadfard, Payam Sasan-Nezhad, Mahmood R. Azarpazhooh, Ariane Sadr-Nabavi   +8 more
doaj   +1 more source

Effect of Angiotensin II Type 1 Receptor Blockade on Cardiac Remodeling in Angiotensin II Type 2 Receptor Null Mice [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2002
To clarify the possible involvement of uninhibited angiotensin II (Ang II) type 2 (AT 2 ) receptor stimulation in the effects of an Ang II type 1 (AT 1 ) receptor blocker, valsartan, we examined the cardiovascular remodeling induced by aortic banding with the use of wild-type ...
Lan, Wu, Masaru, Iwai, Hironori, Nakagami, Rui, Chen, Jun, Suzuki, Masahiro, Akishita, Marc, de Gasparo, Masatsugu, Horiuchi   +7 more
openaire   +2 more sources

Angiotensin Converting Enzyme and Angiotensin II Type 1 Receptor Polymorphisms in Patients with Coronary Aneurysms

Thrombosis Journal, 2003
Background Conflicting results have been reported regarding the association of gene polymorphisms in the renin-angiotensin system (RAS) with different aspects of coronary artery disease (CAD), such as myocardial infarction, neointimal hyperplasia or ...
Helbecque Nicole, Lablanche Jean-Marc, Hermant Xavier, Lamblin Nicolas, Amouyel Philippe, Bauters Christophe   +5 more
doaj   +1 more source

Angiotensin II Type 1 Receptor Antibodies and Increased Angiotensin II Sensitivity in Pregnant Rats [PDF]

Hypertension, 2011
Pregnant women who subsequently develop preeclampsia are highly sensitive to infused angiotensin (Ang) II; the sensitivity persists postpartum. Activating autoantibodies against the Ang II type 1 (AT 1 ) receptor are present in preeclampsia.
Katrin, Wenzel, Augustine, Rajakumar, Hannelore, Haase, Nele, Geusens, Norbert, Hubner, Herbert, Schulz, Justin, Brewer, Lyndsay, Roberts, Carl A, Hubel, Florian, Herse, Lydia, Hering, Fatimunnisa, Qadri, Carsten, Lindschau, Gerd, Wallukat, Robert, Pijnenborg, Harald, Heidecke, Gabriela, Riemekasten, Friedrich C, Luft, Dominik N, Muller, Babette, Lamarca, Ralf, Dechend   +20 more
openaire   +2 more sources

Angiotensin II Type 1 Receptor‐Associated Protein Regulates Kidney Aging and Lifespan Independent of Angiotensin

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundThe kidney is easily affected by aging‐associated changes, including glomerulosclerosis, tubular atrophy, and interstitial fibrosis. Particularly, renal tubulointerstitial fibrosis is a final common pathway in most forms of progressive renal ...
Kazushi Uneda, Hiromichi Wakui, Akinobu Maeda, Kengo Azushima, Ryu Kobayashi, Sona Haku, Kohji Ohki, Kotaro Haruhara, Sho Kinguchi, Miyuki Matsuda, Masato Ohsawa, Shintaro Minegishi, Tomoaki Ishigami, Yoshiyuki Toya, Yoshitoshi Atobe, Akio Yamashita, Satoshi Umemura, Kouichi Tamura   +17 more
doaj   +1 more source

Regulation of Angiotensin II Type 1 Receptor mRNA and Protein in Angiotensin II–Induced Hypertension [PDF]

Hypertension, 1999
Abstract—Chronic elevations of circulating angiotensin II (Ang II) cause sustained hypertension and enhanced accumulation of intrarenal Ang II by an AT1receptor–dependent process. The present study tested the hypothesis that chronic elevations in circulating Ang II regulate AT1mRNA and protein expression in a tissue-specific manner. Sprague-Dawley rats
L M, Harrison-Bernard, S S, El-Dahr, D F, O'Leary, L G, Navar   +3 more
openaire   +2 more sources

Angiotensin II type 1 receptor blockade in early cirrhosis

Journal of Hepatology, 2007
Fil: Castano, Gustavo Osvaldo. Gobierno de la Ciudad de Buenos Aires. Hospital "Dr. Abel Zubizarreta"; Argentina.
Castaño, Gustavo Osvaldo, Sookoian, Silvia Cristina   +1 more
openaire   +3 more sources

Alamandine reduces leptin expression through the c-Src/p38 MAP kinase pathway in adipose tissue. [PDF]

PLoS ONE, 2017
Obesity is associated with an increased risk of diabetes mellitus, hypertension, and renal dysfunction. Angiotensin 1-7 and alamandine are heptameric renin angiotensin system peptide hormones.
Tsuyoshi Uchiyama, Fumikazu Okajima, Chihiro Mogi, Ayaka Tobo, Shoichi Tomono, Koichi Sato   +5 more
doaj   +1 more source