Results 21 to 30 of about 134,000 (307)
Biomedicines, 2023 The present study examined the underlying mechanisms of mechanical allodynia and thermal hyperalgesia induced by the intracisternal injection of angiotensin (Ang) II.
Ki-Don Park +8 more
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Angiotensin II Type 2 Receptor Antagonizes Angiotensin II Type 1 Receptor–Mediated Cardiomyocyte Autophagy [PDF]
Hypertension, 2009 Autophagy has emerged as an important process in the pathogenesis of cardiovascular diseases, but the proximal triggers for autophagy are unknown. Angiotensin II plays a central role in the pathogenesis of cardiac hypertrophy and heart failure. In this study, we used angiotensin II type 1 (AT 1 ) and type 2 (AT
Porrello, Enzo R. +6 more
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Angiotensin II Type 1 Receptor Autoantibodies in Primary Aldosteronism [PDF]
Hormone and Metabolic Research, 2020 AbstractPrimary aldosteronism (PA) is the most common form of endocrine hypertension. Agonistic autoantibodies against the angiotensin II type 1 receptor (AT1R-Abs) have been described in transplantation medicine and women with pre-eclampsia and more recently in patients with PA.
Meyer, Lucie S. +3 more
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The angiotensin II type 1 receptor and receptor-associated proteins [PDF]
Cell Research, 2001 The mechanisms of regulation, activation and signal transduction of the angiotensin II (Ang II) type 1 (AT1) receptor have been studied extensively in the decade after its cloning. The AT1 receptor is a major component of the renin-angiotensin system (RAS). It mediates the classical biological actions of Ang II.
D F, Guo, Y L, Sun, P, Hamet, T, Inagami
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Does activation of the protective Renin-Angiotensin System have therapeutic potential in COVID-19?
Molecular Medicine, 2020 Infection of lung cells by the corona virus results in a loss of the balance between, on the one hand, angiotensin II-mediated stimulation of the angiotensin II type 1 receptor and, on the other hand, stimulation of the angiotensin II type 2 receptor and/
Pawel Namsolleck, Gert N. Moll
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Type 1 angiotensin II receptors in human endometrium [PDF]
Molecular Human Reproduction, 1996 From evidence based on the use of specific receptor subtype antagonists, it has generally been assumed that human uterine tissue contains only type 2 (AT2) angiotensin II (AII) receptor subtype. Using a monoclonal antibody, 6313/G2, directed against a specific sequence in the extracellular domain of the type 1 AII receptor (AT1), in immunocytochemical ...
E, Saridogan +6 more
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018 BackgroundThe classical renin‐angiotensin system is known as the angiotensin (Ang)‐converting enzyme/Ang II/Ang type 1 receptor axis, which induces various organ damage including cognitive decline.
Akinori Higaki +12 more
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Therapeutic targets in the brain for overactive bladder: A focus on angiotensin II type 1 receptor
Journal of Pharmacological Sciences, 2023 Overactive bladder is a condition that affects both men and women, and significantly affects patients' quality of life. Anticholinergics, β3-adrenoceptor agonists, and botulinum toxin are currently being used for treatment.
Shogo Shimizu
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Angiotensin II Type 1 Receptor Blockers [PDF]
Circulation, 2001 In the 1970s, a series of observations demonstrated that angiotensin II has deleterious effects on the heart and kidney and that patients with high levels of plasma renin activity are at a higher risk of developing stroke or myocardial infarction than those with low plasma renin activity.1 2 Thereafter, the development of pharmacological probes that ...
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Cardiovascular Diabetology, 2012 Background In diabetes, a variety of pro-inflammatory cellular changes has been found in various cell types, including monocytes which are known to be involved in all the phases of atherogenesis.
Marino Franca +11 more
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