Results 11 to 20 of about 136,173 (262)

Angiotensin II Type 2 Receptor Antagonizes Angiotensin II Type 1 Receptor–Mediated Cardiomyocyte Autophagy [PDF]

Hypertension, 2009
Autophagy has emerged as an important process in the pathogenesis of cardiovascular diseases, but the proximal triggers for autophagy are unknown. Angiotensin II plays a central role in the pathogenesis of cardiac hypertrophy and heart failure. In this study, we used angiotensin II type 1 (AT 1 ) and type 2 (AT
Porrello, Enzo R., D'Amore, Angelo, Curl, Claire L., Allen, Andrew M., Harrap, Stephen B., Thomas, Walter G., Delbridge, Lea M. D.   +6 more
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The angiotensin II type 1 receptor and receptor-associated proteins [PDF]

Cell Research, 2001
The mechanisms of regulation, activation and signal transduction of the angiotensin II (Ang II) type 1 (AT1) receptor have been studied extensively in the decade after its cloning. The AT1 receptor is a major component of the renin-angiotensin system (RAS). It mediates the classical biological actions of Ang II.
D F, Guo, Y L, Sun, P, Hamet, T, Inagami
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Angiotensin II Type 1 Receptor Autoantibodies in Primary Aldosteronism [PDF]

Hormone and Metabolic Research, 2020
AbstractPrimary aldosteronism (PA) is the most common form of endocrine hypertension. Agonistic autoantibodies against the angiotensin II type 1 receptor (AT1R-Abs) have been described in transplantation medicine and women with pre-eclampsia and more recently in patients with PA.
Meyer, Lucie S., Gong, Siyuan, Reincke, Martin, Williams, Tracy Ann   +3 more
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Type 1 angiotensin II receptors in human endometrium [PDF]

Molecular Human Reproduction, 1996
From evidence based on the use of specific receptor subtype antagonists, it has generally been assumed that human uterine tissue contains only type 2 (AT2) angiotensin II (AII) receptor subtype. Using a monoclonal antibody, 6313/G2, directed against a specific sequence in the extracellular domain of the type 1 AII receptor (AT1), in immunocytochemical ...
E, Saridogan, O, Djahanbakhch, J R, Puddefoot, C, Demetroulis, R, Dawda, A J, Hall, G P, Vinson   +6 more
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Angiotensin II Type 1 Receptor Blockers [PDF]

Circulation, 2001
In the 1970s, a series of observations demonstrated that angiotensin II has deleterious effects on the heart and kidney and that patients with high levels of plasma renin activity are at a higher risk of developing stroke or myocardial infarction than those with low plasma renin activity.1 2 Thereafter, the development of pharmacological probes that ...
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Characterization of a mutant type-1 angiotensin II receptor

Kidney International, 1994
We have used PCR to amplify the rat AT1 receptor from liver mRNA. The receptor DNA was subcloned into pcDNAI and a number of individual clones were transiently expressed in COS-7 cells. These individual receptors were characterized by binding of [125I] Sar1, Ile8-angiotensin II.
Roche, Peter J., Eddie, Lawrence W., Coghlan, John P.   +2 more
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ANGIOTENSIN II RECEPTOR TYPE 1 EXPRESSION IN PATIENTS WITH MULTIFOCAL ATHEROSCLEROSIS

Российский кардиологический журнал, 2016
Local expression of rennin-angiotensin system (RAS) components significantly increases in patients with arterial hypertension and atherosclerosis with or without elevation of RAS activity in the blood.
I. S. Mykhailichenko
doaj   +1 more source

Enhancement of Adipocyte Browning by Angiotensin II Type 1 Receptor Blockade. [PDF]

PLoS ONE, 2016
Browning of white adipose tissue (WAT) has been highlighted as a new possible therapeutic target for obesity, diabetes and lipid metabolic disorders, because WAT browning could increase energy expenditure and reduce adiposity.
Kana Tsukuda, Masaki Mogi, Jun Iwanami, Harumi Kanno, Hirotomo Nakaoka, Xiao-Li Wang, Hui-Yu Bai, Bao-Shuai Shan, Masayoshi Kukida, Akinori Higaki, Toshifumi Yamauchi, Li-Juan Min, Masatsugu Horiuchi   +12 more
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Assessing the Relationship of Angiotensin II Type 1 Receptors with Erythropoietin in a Human Model of Endogenous Angiotensin II Type 1 Receptor Antagonism [PDF]

Cardiorenal Medicine, 2015
<b><i>Hypothesis/Introduction:</i></b> Angiotensin II (Ang II) has been shown to control erythropoietin (EPO) synthesis as Ang II type 1 receptor (AT1R) blockers block Ang-II-induced EPO oversecretion. To further explore the involvement of AT1R in processes controlling EPO levels, plasma EPO and mononuclear cell NADPH oxidase 4 (
CALO', LORENZO, Davis, Pa, Maiolino, G, PAGNIN, ELISA, RAVAROTTO, VERDIANA, NASO, ELENA, Carraro, G, Naso, A.   +7 more
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Angiotensin II type 1 receptor expression in human pancreatic cancer and growth inhibition by angiotensin II type 1 receptor antagonist [PDF]

FEBS Letters, 2001
We investigated the expression of angiotensin II type 1 receptor (AT1) in pancreatic cancer. Both AT1 mRNA and protein were expressed in human pancreatic cancer tissues and cell lines. Binding assays showed that pancreatic cancer cells have specific binding sites for angiotensin II and that binding could be eliminated by treatment with a selective AT1 ...
Fujimoto, Yoshifumi, Sasaki, Tamito, Tsuchida, Akira, Chayama, Kazuaki   +3 more
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