Results 11 to 20 of about 134,000 (307)

Advances in the allostery of angiotensin II type 1 receptor [PDF]

Cell & Bioscience, 2023
Angiotensin II type 1 receptor (AT1R) is a promising therapeutic target for cardiovascular diseases. Compared with orthosteric ligands, allosteric modulators attract considerable attention for drug development due to their unique advantages of high ...
Xi Zhang, Suli Zhang, Meili Wang, Hao Chen, Huirong Liu   +4 more
doaj   +4 more sources

Angiotensin II modulates THP-1-like macrophage phenotype and inflammatory signatures via angiotensin II type 1 receptor [PDF]

Frontiers in Cardiovascular Medicine, 2023
Angiotensin II (Ang II) is a major component of the renin–angiotensin or renin–angiotensin–aldosterone system, which is the main element found to be involved in cardiopathology.
Tlili Barhoumi, Fatmah A. Mansour, Maroua Jalouli, Hassan S. Alamri, Rizwan Ali, Abdel Halim Harrath, Maha Aljumaa, Mohamed Boudjelal   +7 more
doaj   +2 more sources

Inhibition of (pro)renin Receptor Contributes to Renoprotective Effects of Angiotensin II Type 1 Receptor Blockade in Diabetic Nephropathy [PDF]

Frontiers in Physiology, 2017
Aims: Renal renin-angiotensin system (RAS) plays a pivotal role in the development of diabetic nephropathy (DN). Angiotensin II (Ang II) type 1 receptor (AT1R) blockade elevates (pro)renin, which may bind to (pro)renin receptor (PRR) and exert receptor ...
Lin Zhang, Xiao-Fei An, Xin Ruan, Dong-Dong Huang, Li Zhou, Hong Xue, Li-Min Lu, Ming He   +7 more
doaj   +2 more sources

miR-155 suppresses angiotensin II type 1 receptor synthesis during placental morphogenesis [PDF]

Cell Death Discovery
Several microRNAs play vital roles in placental development. miR-155 has been implicated in placental development and can directly interact with a variety of targets, including angiotensin type II receptor 1 (AT1R) (Agtr1) mRNA.
Anya L. Arthurs, Eugenie R. Lumbers, Lachlan Schofield, Celine Lees, Peck Y. Chin, Alison S. Care, Sarah A. Robertson, John E. Schjenken, Kirsty G. Pringle   +8 more
doaj   +2 more sources

Candesartan inhibits inflammation through an angiotensin II type 1 receptor independent way in human embryonic kidney epithelial cells [PDF]

Anais da Academia Brasileira de Ciências, 2019
: Besides stimulating vasoconstriction, Angiotensin II is also well known in inducing reactive oxygen species and promoting inflammatory phenotype switch via its type 1 receptor.
YING YU, HAIFENG JIANG, YANGYANG NIU, XIAOQIN ZHANG, YINGYING ZHANG, XI LIU, TAO QI, CHEN YU   +7 more
doaj   +2 more sources

MicroRNA-155 mediates endogenous angiotensin II type 1 receptor regulation: implications for innovative type 2 diabetes mellitus management. [PDF]

World J Diabetes, 2023
Papadopoulos KI, Papadopoulou A, Aw TC.
europepmc   +2 more sources

Role of agonistic autoantibodies to the angiotensin II type 1 receptor (AT1-AA) in pathogenesis of preeclampsia. [PDF]

Glob Med Genet
Wang J, Shan L, Zhao Y, Cao H, Lan S, Yan Y.   +5 more
europepmc   +2 more sources

Recovery from post-COVID-19 vaccination biliary ductopenia and multiorgan inflammation: A case with insight from angiotensin II type 1 receptor antibody- mediated injury [PDF]

, 2023
Chang A, Jeng Y, Ho C, Lee P.
europepmc   +2 more sources

Upregulation of NADH/NADPH oxidase 4 by angiotensin II induces podocyte apoptosis [PDF]

Kidney Research and Clinical Practice, 2023
Background Angiotensin II induces glomerular and podocyte injury via systemic and local vasoconstrictive or non-hemodynamic effects including oxidative stress. The release of reactive oxygen species (ROS) from podocytes may participate in the development
Tae-Sun Ha, Su-Bin Seong, Dong-Soo Ha, Seung Jung Kim   +3 more
doaj   +1 more source

Validation of six commercially available angiotensin II type 1 receptor antibodies [PDF]

Acta Biochimica et Biophysica Sinica
Li Bingjie, Zhang Xi, Sun Fei, Zhang Xingzhong, Liu Huirong, Zhang Suli   +5 more
doaj   +2 more sources