Results 121 to 130 of about 39,438,208 (302)

Effect of an angiotensin II type 1 receptor blocker on caveolin-1 expression in prostate cancer cells

Archives of Medical Science, 2013
Caveolin-1, the major structural protein of caveolae, interacts directly with the AT1 receptor. The biological functions of caveolin-1 in cancer are compound, multifaceted, and depend on cell type, tumour grade and cancer stage. The AT1-R-caveolin complex in caveolae may coordinate angiotensin II (Ang II) induced signalling.
Piastowska-Ciesielska, Agnieszka Wanda, Kozłowski, Marcin, Wagner, Waldemar, Domińska, Kamila, Ochędalski, Tomasz   +4 more
openaire   +2 more sources

Clinical Impact of Adherence to Fractional Flow Reserve Guidance in Acute Coronary Syndrome

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Fractional flow reserve (FFR) is established to guide revascularization in stable coronary disease and non‐culprit lesions in acute coronary syndromes (ACS). However, real‐world adherence to FFR guidance across the spectrum of ACS presentations, including ambiguous culprit scenarios, remains incompletely characterized.
Eun Ho Choo, Ik Jun Choi, Sungmin Lim, Donggyu Moon, Dae‐Won Kim, Kiyuk Chang   +5 more
wiley   +1 more source

Renovascular and renoprotective properties of telmisartan: clinical utility

International Journal of Nephrology and Renovascular Disease, 2010
Marco Ladino, Ivonne Hernandez SchulmanNephrology-Hypertension Section, Veterans Affairs Medical Center and Division of Nephrology and Hypertension and Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL ...
Marco Ladino, Ivonne Hernandez Schulman
doaj  

Astroglia are a possible cellular substrate of angiotensin(1-7) effects in the rostral ventrolateral medulla [PDF]

, 2010
AIMS: Angiotensin(1-7) (Ang1-7) acting at the level of the rostral ventrolateral medulla (RVLM) affects arterial pressure. The cellular substrate of Ang1-7 remains unknown.
Tang, F, Fang Guo, Feige Tang, Samantha Lane, Souslova, E A, Ekaterina A. Souslova, Paton, JFR, Lane, S, Sergey Kasparov, Dmitriy M. Chudakov, Kasparov, S, Guo, F, Chudakov, D M, Liu, B, Beihui Liu, Julian F.R. Paton   +15 more
core   +1 more source

Baseline Body Mass Index Category and Incident Treated Hypertension in Australian Men: A Linked Prospective Cohort Study Using PBS/MBS Data

Chronic Diseases and Translational Medicine, EarlyView.
Kaplan–Meier hypertension‐free survival by baseline body mass index category, primary adult cohort (men aged ≥ 18 years, n = 12,742). Time since baseline in years is plotted on the horizontal axis and the probability of remaining free of treated hypertension is plotted on the vertical axis. Numbers at risk are shown beneath the plot.
Ebenezer Afrifa‐Yamoah
wiley   +1 more source

Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFβ signaling

FEBS Open Bio, 2014
Staphylococcal nuclease domain containing-1 (SND1) is overexpressed in human hepatocellular carcinoma (HCC) patients and promotes tumorigenesis by human HCC cells.
Prasanna K. Santhekadur, Maaged Akiel, Luni Emdad, Rachel Gredler, Jyoti Srivastava, Devaraja Rajasekaran, Chadia L. Robertson, Nitai D. Mukhopadhyay, Paul B. Fisher, Devanand Sarkar   +9 more
doaj   +1 more source

Mechanism of Angiotensin II Type 1 Receptor Blocker Action in the Regression of Left Ventricular Hypertrophy

The Journal of Clinical Hypertension, 2006
Left ventricular hypertrophy refers to a pathologic increase in left ventricular mass and is associated with an increased risk of subsequent cardiovascular morbidity and mortality from any cause. In the development of left ventricular hypertrophy there is growth of cardiomyocytes and accumulation of extracellular matrix and fibrosis.
Sverre E, Kjeldsen, Arne, Strand, Stevo, Julius, Peter M, Okin   +3 more
openaire   +3 more sources

Initiation of Gabapentin with Opioids and Risk of Respiratory Cardiovascular and Opioid‐Related Adverse Events Following Surgery for Breast Cancer

Clinical Pharmacology &Therapeutics, EarlyView.
Pain is a key determinant of quality‐of‐life following breast cancer surgery, the most common cancer operation in the United States. Gabapentinoids are frequently prescribed for pain management, yet their respiratory, cardiovascular, and opioid‐related adverse effects remain unclear.
Jyun‐Heng Lai, Anton L V Avanceña, Juan P Cata, Jamie C. Barner, Sharon H. Giordano, Chanhyun Park, Hui Zhao, Kirk E. Evoy, John K. Lin, Jennifer C. Spencer, Mariana Chavez‐MacGregor, Kelly K. Hunt, Kerollos Nashat Wanis   +12 more
wiley   +1 more source

Genetic Polymorphisms of the Angiotensin Ii Type 1 Receptor Gene and Diastolic Heart Failure

, 2011
Objectives The aim of the study was to investigate the association between angiotensin II type 1 receptor (AGTR1) gene polymorphisms and diastolic heart failure (DHF) in a case controlled study.
WU, CHO-KAI;TSAI, CHIA-TI;CHANG, YI-CHENG;LUO, JING-LING;WANG, YI-CHIH;HWANG, JUEY-JEN;LIN, JIUNN-LEE;TSENG, CHUEN-DEN;CHIANG, FU-TIEN, 吳卓鍇;蔡佳醍;張益誠;羅景齡;王怡智;黃瑞仁;林俊立;曾春典;江福田   +1 more
core   +1 more source

Enhancing Evidence Generation by Linking Randomized Clinical Trials to Real‐World Data: The INVESTED‐Medicare Linkage Study

Clinical Pharmacology &Therapeutics, EarlyView.
Real‐world evidence (RWE) derived from real‐world data (RWD) can complement randomized controlled trials (RCTs), yet the validity of RWD relative to RCT data remains insufficiently characterized. We obtained post hoc consent and linked individual participant data from the US‐based INVESTED trial (2016–2019) with Medicare fee‐for‐service claims (2012 ...
Hanseul Cho, HoJin Shin, Mehdi Najafzadeh, Brian Claggett, Janinne Ortega‐Montiel, Jun Liu, Julie M. Paik, Narlina F. Lalani, Marie C. Bradley, John Concato, Scott D. Solomon, Orly Vardeny, Elisabetta Patorno   +12 more
wiley   +1 more source