Results 71 to 80 of about 39,438,208 (302)

Intelligent Programmable Membrane Nanosponge for Early Virus Blocking

Advanced Science, EarlyView.
A smart programmable nanosponge (ACNPs) displays high‐density viral receptors on its membrane and encapsulates fusion inhibitors to capture virions at the infection source through competitive binding and blocks their entry through protease inhibition for ultra‐early cascade interception. This modular, mucus‐penetrating platform shifts antiviral defence
Ze Chen, Zhuojun He, Huimin Guo, Min Shi, Ruijing Liang, Lanlan Liu, Yeneng Dai, Qi Zhao, Ke Liu, Yang Zhou, Yang Zhang, Jian Ren, Bin Ju, Quan Fang, Zhaozhen Li, Pengfei Zhao, Mingbin Zheng, Lintao Cai   +17 more
wiley   +1 more source

AT1-receptor response to non-saturating Ang-II concentrations is amplified by calcium channel blockers

BMC Cardiovascular Disorders, 2017
Background Blockers of angiotensin II type 1 receptor (AT1R) and the voltage gated calcium channel 1.2 (CaV1.2) are commonly used for treatment of hypertension.
Kristoffer Bernhem, Kalaiselvan Krishnan, Alexander Bondar, Hjalmar Brismar, Anita Aperia, Lena Scott   +5 more
doaj   +1 more source

The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ

Advanced Science, EarlyView.
UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi, Yu‐Hui Gu, Kai‐Wen Ren, Xiao‐Hong Yu, Yun‐Long Xia, Xiao‐Lei Yang, Hui‐Hua Li   +6 more
wiley   +1 more source

Telmisartan reduces systemic inflammation and alters the renin-angiotensin system in mild COVID-19

Scientific Reports
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, a respiratory viral infection that disrupts renin angiotensin system (RAS) peptide metabolism by downregulating angiotensin converting enzyme-II (ACE2), leading to accumulation
Angela Lu, Melissa Agsalda-Garcia, Weiyuan Hu, Catherine Chester, Aditya Anil Naik, Brooks I. Mitchell, Isaac Asante, Scott A. Souza, Kuo-Chiang Lian, Zao Zhang, Hannah V. Schmitz, Malia L. Ramirez, Richa Varshney, Serena DelMundo, Dominic C. Chow, Cecilia M. Shikuma, Stan G. Louie   +16 more
doaj   +1 more source

Angiotensin II type 1 receptor blocker inhibits arterial calcification in a pre-clinical model [PDF]

Cardiovascular Research, 2010
Arterial calcification is a common complication of several disorders and is a strong predictor of mortality. The mechanism underlying arterial calcification is not fully understood and as such, no pharmaceutical therapies are currently available which impede its progression.
Zachary B, Armstrong, Derek R, Boughner, Maria, Drangova, Kem A, Rogers   +3 more
openaire   +2 more sources

Acute kidney injury: an acceptable risk of treatment with renin-angiotensin system blockade in primary care? [PDF]

, 2015
Background: Use of renin-angiotensin system (RAS) blockade has become increasingly widespread driven by evidence-based guidance. There is concern about the role of these agents in the genesis of avoidable acute kidney injury (AKI).
Jean Irving, Paul E Stevens, Irving, Jean, Michael Bedford, Bedford, Michael, Stevens, Paul E., Christopher KT Farmer, Farmer, Christopher K.   +7 more
core   +2 more sources

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Beyond blood pressure: the renin-angiotensin system as an innovative driver and therapeutic target in pathological scarring

Frontiers in Pharmacology
Pathological scarring, a fibroproliferative disorder, imposes a substantial burden on affected individuals. This review explores the pivotal role of the local cutaneous renin-angiotensin system (RAS) in the pathogenesis of pathological scarring.
Bang-Hui Shi, Xin-Ge Zhang, Qing-Qing Fang, Kai Xu, Xiao-Ling Chen, Wei-Qiang Tan, Shou-Jie Wang, Shou-Jie Wang   +7 more
doaj   +1 more source

Preclinical and clinical profile of valsartan, a selective angiotensin II type-1 receptor blocker.

Folia Pharmacologica Japonica, 2002
Valsartan (Diovan) is a potent, orally active, specific, and highly selective blocker for the AT1-receptor subtype. The antihypertensive effects of oral treatment with valsartan were preclinically demonstrated in the sodium-depleted marmosets, renal hypertensive rats (2K1C), spontaneous hypertensive rats (SHR) and stroke-prone SHR.
KIMURA, Masaaki, MITANI, Hironobu, ISOMURA, Yasuo   +2 more
openaire   +3 more sources

Reappraisal of role of angiotensin receptor blockers in cardiovascular protection

, 2011
C Venkata S RamTexas Blood Pressure Institute, Clinical Research Institute of Dallas Nephrology Associates; and Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USAAbstract: Angiotensin-converting ...
Ram CV, C V Ram
core   +1 more source