Results 61 to 70 of about 192,985 (344)

Enhancement of Adipocyte Browning by Angiotensin II Type 1 Receptor Blockade. [PDF]

PLoS ONE, 2016
Browning of white adipose tissue (WAT) has been highlighted as a new possible therapeutic target for obesity, diabetes and lipid metabolic disorders, because WAT browning could increase energy expenditure and reduce adiposity.
Kana Tsukuda, Masaki Mogi, Jun Iwanami, Harumi Kanno, Hirotomo Nakaoka, Xiao-Li Wang, Hui-Yu Bai, Bao-Shuai Shan, Masayoshi Kukida, Akinori Higaki, Toshifumi Yamauchi, Li-Juan Min, Masatsugu Horiuchi   +12 more
doaj   +1 more source

Liver steatosis, cardiac and renal fibrosis, and hypertension in overweight rats: Angiotensin-(3–4)-sensitive hepatocardiorenal syndrome

Metabolism Open, 2022
Overweight/obesity is a growing pandemic that affects many organs and tissues. We have investigated whether a high-lipid diet provokes an imbalance between type 1 and type 2 angiotensin II (Ang II) receptors signaling, leading to liver alterations ...
Thuany Crisóstomo, Marco A.E. Pardal, Simone A. Herdy, Humberto Muzi-Filho, Debora B. Mello, Christina M. Takiya, Rafael Luzes, Adalberto Vieyra   +7 more
doaj   +1 more source

The angiotensin II type 2 (AT2) receptor: an enigmatic seven transmembrane receptor

Frontiers in Bioscience, 2009
Angiotensin II (AngII) interacts with two receptor subtypes, AT1 and AT2, belonging to the seven transmembrane receptor superfamily. Pharmacological investigations initially suggested that AT2 receptors antagonize AT1 effects. Data from AT2 receptor transgenic and knock-out mice have not been entirely consistent with this interpretation.
Porrello, Enzo R., Delbridge, Lea M. D., Thomas, Walter G.   +2 more
openaire   +5 more sources

Testosterone downregulates angiotensin II type-2 receptor via androgen receptor-mediated ERK1/2 MAP kinase pathway in rat aorta

Journal of the Renin-Angiotensin-Aldosterone System, 2016
Introduction: Blood pressure is lower in females than males. Angiotensin II type-2 receptor (AT2R) induces vasodilation. This study determined whether sex differences in vascular AT2R expression occur and if androgens exert control on AT2R expression in ...
J. Mishra, G. Hankins, Sathish Kumar
semanticscholar   +1 more source

Changes in Angiotensin II Type 1 Receptor Expression in the Rat Bladder by Bladder Outlet Obstruction [PDF]

, 2012
Purpose: To demonstrate the change in the expression of angiotensin II type 1 receptor (AT1) in the rat bladder with partial bladder outlet obstruction (P-BOO).
Tobu, Shohei, Matsuo, Manabu, Mori, Ken-ichi, Sakai, Hideki, Hatada, Teppei, Noguchi, Mitsuru   +5 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Hypertension regulating angiotensin peptides in the pathobiology of cardiovascular disease

Clinical and Experimental Hypertension, 2018
Renin angiotensin system (RAS) is an endogenous hormone system involved in the control of blood pressure and fluid volume. Dysregulation of RAS has a pathological role in causing cardiovascular diseases through hypertension.
Misbah Hussain, Fazli Rabbi Awan
doaj   +1 more source

The Tissue Renin-Angiotensin System and Its Role in the Pathogenesis of Major Human Diseases: Quo Vadis?

Cells, 2021
Evidence has arisen in recent years suggesting that a tissue renin-angiotensin system (tRAS) is involved in the progression of various human diseases. This system contains two regulatory pathways: a pathological pro-inflammatory pathway containing the ...
Babak Saravi, Zhen Li, Corinna N. Lang, Bonaventura Schmid, Frauke K. Lang, Sibylle Grad, Mauro Alini, Robert Geoffrey Richards, Hagen Schmal, Norbert Südkamp, Gernot M. Lang   +10 more
doaj   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Mild hypothermia alleviates post-resuscitation cerebral injury in rats via modulating the balance of the renin–angiotensin system

Resuscitation Plus
Cardiac arrest and cardiopulmonary resuscitation represent a major cause of mortality. Cerebral ischemia–reperfusion injury following Cardiac arrest and cardiopulmonary resuscitation leads to severe neurological deficits and significantly worsens patient
Yongjing He, Qianqian Wu, Sisi Huang, Dan Wu, Yuansheng Zhan, Jiaqiang Deng, Beizhu Xu, Lu Xie, Junhui Zheng   +8 more
doaj   +1 more source