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The Angiotensin IV System: Functional Implications
Frontiers in Neuroendocrinology, 1995The brain renin-angiotensin system has been implicated in the central regulation of the cardiovascular system, body water balance, and cyclic regulation of reproductive hormones and behaviors. It also exerts some influence over the secretion of pituitary hormones.
J W, Wright +3 more
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The Journal of Pharmacology and Experimental Therapeutics, 1999
125I-Angiotensin (Ang) IV and (125)I-divalinal Ang IV [AT receptor subtype 4 (AT(4))] receptor agonist and putative antagonist, respectively] were used to characterize the AT(4) receptor in Mardin-Darby bovine kidney epithelial cells (MDBK cell line). Both (125)I-Ang IV and (125)I-divalinal Ang IV bound to a single high-affinity site (K(D) = 1.37 and 1.
R K, Handa, J W, Harding, S M, Simasko
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125I-Angiotensin (Ang) IV and (125)I-divalinal Ang IV [AT receptor subtype 4 (AT(4))] receptor agonist and putative antagonist, respectively] were used to characterize the AT(4) receptor in Mardin-Darby bovine kidney epithelial cells (MDBK cell line). Both (125)I-Ang IV and (125)I-divalinal Ang IV bound to a single high-affinity site (K(D) = 1.37 and 1.
R K, Handa, J W, Harding, S M, Simasko
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The angiotensin IV/AT4 receptor.
Cellular and molecular life sciences : CMLS, 2004The angiotensin AT(4) receptor was originally defined as the specific, high-affinity binding site for the hexapeptide angiotensin IV (Ang IV). Subsequently, the peptide LVV-hemorphin 7 was also demonstrated to be a bioactive ligand of the AT(4) receptor.
S Y, Chai +6 more
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Important roles for angiotensin III and IV in the brain renin-angiotensin system
Brain Research Reviews, 1997Considerable evidence now suggests that the precursors and enzymes necessary for the formation and degradation of biologically active forms of angiotensins are present in brain tissues, accompanied by at least three specific binding sites. It also appears that several forms of angiotensin may serve as signaling agents at these sites.
J W, Wright, J W, Harding
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β-Homo-amino Acid Scan of Angiotensin IV
Journal of Medicinal Chemistry, 2008Angiotensin IV, a metabolite of angiotensin II, inhibits the enzyme insulin regulated aminopeptidase or IRAP and also, although with lower potency, aminopeptidase-N (AP-N). When both beta (2)-homo amino acid- and beta (3)-homo amino acid substitutions were used, allowed the identification of H-( R)beta (2)hVal-Tyr-Ile-His-Pro-beta (3)hPhe-OH as a ...
Lukaszuk, Aneta +9 more
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Peptides, 2004
An important role for angiotensin IV (Ang IV) in the processes of learning and memory has now been well established. We have previously found that intracerebroventricular (ICV) administration of Ang IV as well as des-Phe6-Ang IV enhances learning of conditioned avoidance responses (CARs), facilitates recall of a passive avoidance (PA) task, and ...
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An important role for angiotensin IV (Ang IV) in the processes of learning and memory has now been well established. We have previously found that intracerebroventricular (ICV) administration of Ang IV as well as des-Phe6-Ang IV enhances learning of conditioned avoidance responses (CARs), facilitates recall of a passive avoidance (PA) task, and ...
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Comparative effects of angiotensin IV and two hemorphins on angiotensin-converting enzyme activity
Peptides, 2002The role of angiotensin IV (AngIV) in the regulation of angiotensin-converting enzyme (ACE) was studied in vitro. This study demonstrates that this active fragment appeared as a novel endogenous ACE inhibitor. Inhibitory kinetic studies revealed that AngIV acts as a purely competitive inhibitor with a K(i) value of 35 microM.
Fruitier-Arnaudin, Ingrid +4 more
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Heart Failure Reviews, 2007
For decades, angiotensin (Ang) II was considered as the end product and the only bioactive peptide of the renin-angiotensin system (RAS). However, later studies revealed biological activity for other Ang fragments. Amongst those, Ang IV has drawn a lot of attention since it exerts a wide range of central and peripheral effects including the ability to ...
Stragier, Bart +7 more
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For decades, angiotensin (Ang) II was considered as the end product and the only bioactive peptide of the renin-angiotensin system (RAS). However, later studies revealed biological activity for other Ang fragments. Amongst those, Ang IV has drawn a lot of attention since it exerts a wide range of central and peripheral effects including the ability to ...
Stragier, Bart +7 more
openaire +3 more sources